Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

(2016) Nida Meednu et al.   Arthritis & Rheumatology

A4.3 Effects of anti-TNF therapy on markers of bone homeostasis in rheumatoid arthritis and ankylosing spondylitis

(2015) Horváth Á et al.   ANNALS OF THE RHEUMATIC DISEASES

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

(2015) Hongguo Shao et al.   BIOMATERIALS

A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis

(2015) Ruile Shen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption

(2015) Lei Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion

(2014) H. Raghu et al.   BLOOD

Interleukin-17 regulates the expressions of RANKL and OPG in human periodontal ligament cells via TRAF6/TBK1-JNK/NF-κB pathways

(2014) Danping Lin et al.   IMMUNOLOGY

A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

(2014) Liqun Chi et al.   MEDIATORS OF INFLAMMATION

Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation

(2013) Mian Zhang et al.   APOPTOSIS

Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling

(2013) Xiao-Feng Li et al.   Evidence-based Complementary and Alternative Medicine

Comparative study by computed radiography, histology, and scanning electron microscopy of the articular cartilage of normal goats and in chronic infection with caprine arthritis-encephalitis virus

(2013) Videlina Rodrigues de Sousa et al.   MICROSCOPY RESEARCH AND TECHNIQUE

An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis

(2013) Peijiao Sun et al.   PHYTOMEDICINE

Extracellular Matrix Domain Formation as an Indicator of Chondrocyte Dedifferentiation and Hypertrophy

(2013) Ling Wu et al.   TISSUE ENGINEERING PART C-METHODS

Alterations in the Synthesis of IL-1β, TNF-α, IL-6, and Their Downstream Targets RANKL and OPG by Mouse Calvarial Osteoblasts In vitro: Inhibition of Bone Resorption by Cyclic Mechanical Strain

(2013) Salvador García-López et al.   Frontiers in Endocrinology

RANKL produced by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

(2012) MJ Martínez-Calatrava et al.   ANNALS OF THE RHEUMATIC DISEASES

Progression of joint damage despite control of inflammation in rheumatoid arthritis: a role for cartilage damage driven synovial fibroblast activity: Figure 1

(2012) Floris PJG Lafeber et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

(2012) Timothy P. LaBranche et al.   ARTHRITIS AND RHEUMATISM

Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study

(2012) Nienke Lesuis et al.   BMC Medicine

TRAF Family Member-associated NF-κB Activator (TANK) Is a Negative Regulator of Osteoclastogenesis and Bone Formation

(2012) Kenta Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Icariin: a potential promoting compound for cartilage tissue engineering

(2012) D. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Icariin enhances the healing of rapid palatal expansion induced root resorption in rats

(2012) Feng Wang et al.   PHYTOMEDICINE

The relationship between joint damage and functional disability in rheumatoid arthritis: a systematic review

(2011) Claire Bombardier et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction

(2011) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Maintenance of cartilaginous gene expression on extracellular matrix derived from serially passaged chondrocytes during in vitro chondrocyte expansion

(2011) Takashi Hoshiba et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation

(2010) Man-Hai Liu et al.   NUTRITION RESEARCH

Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro

(2010) M. M. Abouheif et al.   RHEUMATOLOGY

Animal models of rheumatoid arthritis

(2009) Darren L. Asquith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: A novel model of atherosclerosis associated with chronic inflammation

(2008) Raquel Largo et al.   ARTHRITIS AND RHEUMATISM

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols