Defining the Functional Influence of Endothelial Cell–Expressed Oncogenic Activating Mutations on Vascular Morphogenesis and Capillary Assembly

Trafficking in blood vessel development

(2022) Caitlin R. Francis et al.   ANGIOGENESIS

Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression

(2022) Scott S. Kemp et al.   Frontiers in Cell and Developmental Biology

Mouse models of vascular development and disease

(2021) Ondine Cleaver   CURRENT OPINION IN HEMATOLOGY

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

(2021) Aileen A. Ren et al.   NATURE

Selective and marked blockade of endothelial sprouting behavior using paclitaxel and related pharmacologic agents

(2021) Prisca K. Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic Basis and Therapies for Vascular Anomalies

(2021) Angela Queisser et al.   CIRCULATION RESEARCH

Cerebral Cavernous Malformation: From Mechanism to Therapy

(2021) Daniel A. Snellings et al.   CIRCULATION RESEARCH

Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations

(2021) Matthieu Peyre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial k-RasV12 Expression Induces Capillary Deficiency Attributable to Marked Tube Network Expansion Coupled to Reduced Pericytes and Basement Membranes

(2021) Zheying Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Theranostic Advances in Vascular Malformations

(2020) Valérie Dekeuleneer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling

(2020) Jason E Fish et al.   CIRCULATION RESEARCH

Control of endothelial tubulogenesis by Rab and Ral GTPases, and apical targeting of caveolin-1-labeled vacuoles

(2020) Pieter R. Norden et al.   PLoS One

Defining an Upstream VEGF (Vascular Endothelial Growth Factor) Priming Signature for Downstream Factor-Induced Endothelial Cell-Pericyte Tube Network Coassembly

(2020) Stephanie L.K. Bowers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A somatic missense mutation in GNAQ causes capillary malformation

(2019) Colette Bichsel et al.   CURRENT OPINION IN HEMATOLOGY

Building Blood Vessels—One Rho GTPase at a Time

(2019) Haley Rose Barlow et al.   Cells

Vascular Endothelial Cell Biology: An Update

(2019) Krüger-Genge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

(2019) Yuqi Cai et al.   Scientific Reports

Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression

(2019) Gretchen M. Koller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Consensus guidelines for the use and interpretation of angiogenesis assays

(2018) Patrycja Nowak-Sliwinska et al.   ANGIOGENESIS

Vascular Development

(2018) Mark W. Majesky   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Somatic second hit mutation of RASA1 in vascular endothelial cells in capillary malformation-arteriovenous malformation

(2018) Philip E. Lapinski et al.   European Journal of Medical Genetics

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

(2018) Lara Al-Olabi et al.   JOURNAL OF CLINICAL INVESTIGATION

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

(2018) Sergey I. Nikolaev et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular Anomalies

(2018) Arin K. Greene et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke

(2018) Qing-fen Li et al.   Cell Reports

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

(2018) Matthew R. Detter et al.   CIRCULATION RESEARCH

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

Vascular Anomalies Caused by Abnormal Signaling within Endothelial Cells: Targets for Novel Therapies

(2017) Ha-Long Nguyen et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma

(2016) Ugur M. Ayturk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth

(2016) Yeon Koo et al.   ANGIOGENESIS

The pathobiology of vascular malformations: insights from human and model organism genetics

(2016) Sarah E Wetzel-Strong et al.   JOURNAL OF PATHOLOGY

Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1

(2016) Pieter R. Norden et al.   PLoS One

Somatic Activating PIK3CA Mutations Cause Venous Malformation

(2015) Nisha Limaye et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular control of capillary morphogenesis and maturation by recognition and remodeling of the extracellular matrix: functional roles of endothelial cells and pericytes in health and disease

(2015) George E. Davis et al.   CONNECTIVE TISSUE RESEARCH

Common and specific effects of TIE2 mutations causing venous malformations

(2015) Marjut Nätynki et al.   HUMAN MOLECULAR GENETICS

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

(2015) Elisa Boscolo et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling

(2015) Benjamin Lant et al.   Nature Communications

Ultrastructural and immunocytochemical characterization of interstitial cells in pre- and postnatal developing sheep pineal gland

(2015) E Redondo et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Oncogenic Ras/ERK Signaling Activates CDCP1 to Promote Tumor Invasion and Metastasis

(2014) Takamasa Uekita et al.   MOLECULAR CANCER RESEARCH

Hematopoietic Stem Cell Cytokines and Fibroblast Growth factor-2 Stimulate Human Endothelial Cell-Pericyte Tube Co-Assembly in 3D Fibrin Matrices under Serum-Free Defined Conditions

(2014) Annie O. Smith et al.   PLoS One

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

(2014) C. A. Martz et al.   Science Signaling

Vascular Malformations: A Review

(2014) Joshua Cox et al.   Seminars in Plastic Surgery

Pathogenesis of infantile haemangioma

(2013) S. Greenberger et al.   BRITISH JOURNAL OF DERMATOLOGY

Proteus syndrome review: molecular, clinical, and pathologic features

(2013) M. Michael Cohen   CLINICAL GENETICS

Pericyte Loss in Diabetic Retinopathy: Mechanisms and Consequences

(2013) Elena Beltramo et al.   CURRENT MEDICINAL CHEMISTRY

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB

(2013) Melanie Uebelhoer et al.   HUMAN MOLECULAR GENETICS

RASA1Mutations and Associated Phenotypes in 68 Families with Capillary Malformation-Arteriovenous Malformation

(2013) Nicole Revencu et al.   HUMAN MUTATION

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man

(2013) P. E. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructural analysis of vascular features in cerebral cavernous malformations

(2012) Gamze Tanriover et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines

(2011) A. N. Stratman et al.   BLOOD

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

(2011) Ke Xu et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

(2011) Aubrey C. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization

(2011) Amber N. Stratman et al.   MICROSCOPY AND MICROANALYSIS

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis

(2011) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization

(2010) A. N. Stratman et al.   BLOOD

Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis

(2010) Mien V. Hoang et al.   MICROVASCULAR RESEARCH

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasculogenesis in infantile hemangioma

(2009) Elisa Boscolo et al.   ANGIOGENESIS

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices

(2009) A. N. Stratman et al.   BLOOD

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

Formation of endothelial lumens requires a coordinated PKC -, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation

(2009) W. Koh et al.   JOURNAL OF CELL SCIENCE

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Modulation of VEGF signalling output by the Notch pathway

(2008) Arndt F. Siekmann et al.   BIOESSAYS

Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis

(2008) Matthew T. Holderfield et al.   CIRCULATION RESEARCH

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling

(2008) W. Koh et al.   JOURNAL OF CELL SCIENCE