Article
Biochemistry & Molecular Biology
Fei Han, Zi-fan Ding, Xiao-lei Shi, Qing-tian Zhu, Qin-hao Shen, Xing-meng Xu, Jun-xian Zhang, Wei-juan Gong, Wei-ming Xiao, Dan Wang, Wei-wei Chen, Liang-hao Hu, Guo-tao Lu
Summary: The newly discovered myokine irisin can inhibit neutrophil extracellular traps (NETs) formation and protect mice from pancreatic injury. This study further elucidates the protective effect of exercise on acute inflammatory injury.
Article
Oncology
Yanze Yin, Huijuan Dai, Xicheng Sun, Zhifeng Xi, Jiang Zhang, Yixiao Pan, Yongxin Huang, Xueyun Ma, Qiang Xia, Kang He
Summary: This study reveals that liver cancer promotes tumor lung metastasis by regulating neutrophil recruitment and NETs formation in the metastatic microenvironment through reducing HRG secretion. The findings of this study will contribute to the development of possible strategies for treating metastases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Huan Zhao, Yi Liang, Chengtao Sun, Yufei Zhai, Xuan Li, Mi Jiang, Ruiwen Yang, Xiaojuan Li, Qijin Shu, Guoyin Kai, Bing Han
Summary: Dihydrotanshinone I (DHT) has an anti-metastatic effect on breast cancer by inhibiting the growth and migration of cancer cells and reducing lung metastasis progression and distribution. The study also found that DHT inhibits the formation of neutrophil extracellular traps (NETs) to suppress breast cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yumeng Huang, Qian Ji, Yanyan Zhu, Shengqiao Fu, Shuangwei Chen, Liangmei Chu, Yongfei Ren, Yue Wang, Xuan Lei, Jia Gu, Ningzheng Tai, Dadong Liu
Summary: This study found that peripheral 5-HT deficiency can reduce NET formation, alleviate lung inflammation and reduce mortality in sepsis-induced acute lung injury (ALI). It was also found that peripheral 5-HT deficiency can reduce the accumulation of platelets and NETs in the lungs of septic mice. The study uncovers a mechanism by which peripheral 5-HT aggravates sepsis-induced ALI by promoting NET formation in the lungs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marina Stoimenou, Georgios Tzoros, Panagiotis Skendros, Akrivi Chrysanthopoulou
Summary: Several studies suggest that NETs may play a role in inflammatory and thrombotic disorders, thus serving as potential therapeutic or diagnostic tools. This article compares commonly used techniques for assessing NET formation and discusses the challenges and advantages in evaluating NETs. The review provides insights into the molecular analysis of NETs in translational medicine today.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Luyao Zhang, Jun Lu, Zhiyang Wu
Summary: This study demonstrates the significant effects of auricular vagus nerve stimulation (AVNS) on systemic inflammation, lung injury, neutrophil infiltration, and neutrophil extracellular traps (NETs) formation in LPS mice.
Article
Immunology
Renato G. S. Chirivi, Jos W. G. van Rosmalen, Maarten van der Linden, Maximilien Euler, Gonny Schmets, Galina Bogatkevich, Konstantinos Kambas, Jonas Hahn, Quinte Braster, Oliver Soehnlein, Markus H. Hoffmann, Helmuth H. G. van Es, Jos M. H. Raats
Summary: The study demonstrated that therapeutic anti-citrullinated protein antibody can inhibit NET release, reduce tissue damage, and potentially serve as a drug candidate for NET-mediated inflammatory diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Yi Liu, Rong Wang, Congkuan Song, Song Ding, Yifan Zuo, Ke Yi, Ning Li, Bo Wang, Qing Geng
Summary: Transfusion-related acute lung injury (TRALI) is a leading cause of death associated with blood transfusion. TRALI can be categorized into antibody-mediated and non-antibody-mediated types. Neutrophil extracellular traps (NETs) formed by activated neutrophils play a significant role in TRALI. Platelets, macrophages, endothelial cells, and complements also promote NET formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shujing Zou, Hongyu Jie, Xinai Han, Jinghong Wang
Summary: Neutrophil extracellular traps (NETs) play a critical role in the inflammatory response and bacterial clearance, but their excessive activation can cause an inflammatory storm and organ dysfunction. Acute lung injury caused by sepsis is the main cause of organ damage. NET formation can accelerate the development of acute lung injury through the release of cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Review
Immunology
Darko Stojkov, Lea Gigon, Shuang Peng, Robert Lukowski, Peter Ruth, Alexander Karaulov, Albert Rizvanov, Nickolai A. Barlev, Shida Yousefi, Hans-Uwe Simon
Summary: Neutrophils, the most abundant cells in the leukocyte population, can modulate glycolysis and other metabolic pathways to limit their effector functions. These metabolic pathways are crucial for energy usage and specialized actions, such as ROS production, chemotaxis, phagocytosis, degranulation, and the formation of NETs. Understanding the requirements of metabolic pathways for neutrophil functions may lead to the discovery of molecular targets for novel anti-infectious and/or anti-inflammatory drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
In Soo Kim, Do Hyun Kim, Hoi Woul Lee, Sung Gyun Kim, Yong Kyun Kim, Jwa-Kyung Kim
Summary: This study found a strong association between elevated neutrophil extracellular trap (NET) levels and poor clinical outcomes in patients with COVID-19. The role of NETs in COVID-19-associated acute kidney injury (AKI) was also investigated. The results showed that elevated NET levels were closely associated with AKI and were a significant predictor of mortality in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ting Shang, Zhi-Sen Zhang, Xin-Tong Wang, Jing Chang, Meng-En Zhou, Ming Lyu, Shuang He, Jian Yang, Yan-Xu Chang, Yuefei Wang, Ming-Chun Li, Xiumei Gao, Yan Zhu, Yuxin Feng
Summary: The study demonstrates that XBJ can inhibit NETs formation by reversing the GSDMD-related pathway and protect against sepsis-induced lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Jie Zhang, Jiangyan Huo, Zhizhi Zhao, Yan Lu, Zhou Hong, Hong Li, Daofeng Chen
Summary: This study isolated an anticomplement homogeneous polysaccharide HD-PS-3 from Hedyotis diffusa and confirmed its therapeutic effect and mechanism on acute lung injury (ALI). The results showed that HD-PS-3 exhibited anticomplement activity and attenuated lung injury and neutrophil infiltration.
Article
Cardiac & Cardiovascular Systems
Kohsuke Shirakawa, Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Yoshinori Katsumata, Kazuhisa Sugai, Yoji Hakamata, Motoaki Sano
Summary: This study demonstrates that hydrogen gas (H-2) can inhibit the formation of neutrophil extracellular traps (NETs) and excessive neutrophil activation, suggesting its potential as a therapeutic strategy for conditions related to NETs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
