Clinical implication of genetic intratumor heterogeneity for targeted therapy in head and neck cancer

Pembrolizumab Alone or With Chemotherapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma in KEYNOTE-048: Subgroup Analysis by Programmed Death Ligand-1 Combined Positive Score

(2022) Barbara Burtness et al.   JOURNAL OF CLINICAL ONCOLOGY

First-in-human study of PC14586, a small molecule structural corrector of Y220C mutant p53, in patients with advanced solid tumors harboring a TP53 Y220C mutation.

(2022) Ecaterina Elena Dumbrava et al.   JOURNAL OF CLINICAL ONCOLOGY

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer

(2022) Henrik Schinke et al.   Molecular Cancer

Intratumor heterogeneity is biomarker specific and challenges the association with heterogeneity in multimodal functional imaging in head and neck squamous cell carcinoma

(2021) Jacob H. Rasmussen et al.   EUROPEAN JOURNAL OF RADIOLOGY

Intratumoural heterogeneity and clone evolution of oral squamous cell carcinoma

(2021) Lin Wang et al.   MOLECULAR CARCINOGENESIS

Limited evolution of the actionable metastatic cancer genome under therapeutic pressure

(2021) Joris van de Haar et al.   NATURE MEDICINE

Chromosomal copy number heterogeneity predicts survival rates across cancers

(2021) Erik van Dijk et al.   Nature Communications

A Comparison of Tools for Copy-Number Variation Detection in Germline Whole Exome and Whole Genome Sequencing Data

(2021) Migle Gabrielaite et al.   Cancers

Does multiparametric imaging with 18F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?

(2020) Jacob H. Rasmussen et al.   BRITISH JOURNAL OF CANCER

TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection

(2020) Apostolos Klinakis et al.   EBioMedicine

Probability distribution of copy number alterations along the genome: an algorithm to distinguish different tumour profiles

(2020) Luísa Esteves et al.   Scientific Reports

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

(2020) Pooja A. Shah et al.   Cells

Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity

(2019) Dan P. Zandberg et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma

(2019) Jacob H. Rasmussen et al.   BRITISH JOURNAL OF CANCER

Lessons learned from SMAD4 loss in squamous cell carcinomas

(2019) Ariel L. Hernandez et al.   MOLECULAR CARCINOGENESIS

The changing therapeutic landscape of head and neck cancer

(2019) John D. Cramer et al.   Nature Reviews Clinical Oncology

Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy

(2019) Madison Canning et al.   Frontiers in Cell and Developmental Biology

Epigenetic Modifications in Head and Neck Cancer

(2019) Jadwiga Gaździcka et al.   BIOCHEMICAL GENETICS

Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data

(2019) Judith Abécassis et al.   PLoS One

Comprehensive Genomic Review of TCGA Head and Neck Squamous Cell Carcinomas (HNSCC)

(2019) Mario Pérez Sayáns et al.   Journal of Clinical Medicine

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

(2018) J Mateo et al.   ANNALS OF ONCOLOGY

ESCAT: A Step in the Right Direction

(2018) A J Silver et al.   ANNALS OF ONCOLOGY

The promise of ESCAT: a new system for evaluating cancer drug–target pairs

(2018) Bishal Gyawali et al.   Nature Reviews Clinical Oncology

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study

(2017) Lucia Nogova et al.   JOURNAL OF CLINICAL ONCOLOGY

SinaPlot: An Enhanced Chart for Simple and Truthful Representation of Single Observations Over Multiple Classes

(2017) Nikos Sidiropoulos et al.   JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS

The challenges of tumor genetic diversity

(2016) Edmund A. Mroz et al.   CANCER

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas

(2015) Edmund A. Mroz et al.   PLOS MEDICINE

Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinoma

(2015) W Cao et al.   Oncogenesis

Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing

(2015) Xinyi Cindy Zhang et al.   NEOPLASIA

PTEN Deficiency Contributes to the Development and Progression of Head and Neck Cancer

(2015) Cristiane H Squarize et al.   NEOPLASIA

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

Overexpression of EGFR in Head and Neck Squamous Cell Carcinoma Is Associated with Inactivation of SH3GL2 and CDC25A Genes

(2013) Guru Prasad Maiti et al.   PLoS One

Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

(2012) Toshihito Suda et al.   BMC CANCER

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intratumor Heterogeneity: Seeing the Wood for the Trees

(2012) T. A. Yap et al.   Science Translational Medicine