Curcumin Reduces Amyloid Beta Oligomer Interactions with Anionic Membranes

Role of phosphatidylserine in amyloid-beta oligomerization at asymmetric phospholipid bilayers

(2022) Jack Robinson et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Curcumin and Homotaurine Suppress Amyloid-β25–35 Aggregation in Synthetic Brain Membranes

(2021) Xingyuan Zou et al.   ACS Chemical Neuroscience

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

(2021) Sang-Gyun Kang et al.   BMC BIOLOGY

Tau and Membranes: Interactions That Promote Folding and Condensation

(2021) Chad A. Sallaberry et al.   Frontiers in Cell and Developmental Biology

Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface

(2020) Peter Niraj Nirmalraj et al.   Science Advances

Characterization by Nano-Infrared Spectroscopy of Individual Aggregated Species of Amyloid Proteins

(2020) Jehan Waeytens et al.   MOLECULES

A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer’s disease

(2020) Alessio Ausili et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy

(2019) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrillar and Nonfibrillar Amyloid Beta Structures Drive Two Modes of Membrane-Mediated Toxicity

(2019) Crystal M. Vander Zanden et al.   LANGMUIR

Membrane-mediated fibrillation and toxicity of the tau hexapeptide PHF6

(2019) Adeline M. Fanni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol modulates curcumin partitioning and membrane effects

(2018) Natália B. Leite et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Membrane Templated Misfolding and Self-Assembly of Intrinsically Disordered Tau Protein

(2018) Jaroslaw P. Majewski et al.   BIOPHYSICAL JOURNAL

Amyloid β fibrils assembled on ganglioside-enriched membranes contain both parallel β-sheets and turns

(2018) Teruhiko Matsubara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Interactions between Curcumin and Different Types of Lipid Bilayers by Molecular Dynamics Simulation

(2018) Yuan Lyu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes

(2018) Stefania A. Mari et al.   NANO LETTERS

Membrane-Modulating Drugs can Affect the Size of Amyloid-β25–35 Aggregates in Anionic Membranes

(2018) Adree Khondker et al.   Scientific Reports

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

(2018) Oeystein R. Brekk et al.   Scientific Reports

Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning

(2017) Xuewei Dong et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural differences between amyloid beta oligomers

(2016) Leonid Breydo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids

(2016) Rosario Randino et al.   Scientific Reports

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Obtaining information about protein secondary structures in aqueous solution using Fourier transform IR spectroscopy

(2015) Huayan Yang et al.   Nature Protocols

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

(2014) Helgi I. Ingólfsson et al.   ACS Chemical Biology

An antifungal mechanism of curcumin lies in membrane-targeted action withinCandida albicans

(2014) Wonyoung Lee et al.   IUBMB LIFE

Different effects of Alzheimer's peptide Aβ(1–40) oligomers and fibrils on supported lipid membranes

(2013) Claudio Canale et al.   BIOPHYSICAL CHEMISTRY

Binding and Aggregation Mechanism of Amyloid β-Peptides onto the GM1 Ganglioside-Containing Lipid Membrane

(2013) Tyuji Hoshino et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Membrane-Mediated Neuroprotection by Curcumin from Amyloid-β-Peptide-Induced Toxicity

(2013) Arjun Thapa et al.   LANGMUIR

Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption

(2012) Emmalee M. Jones et al.   BIOCHEMISTRY

Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding

(2012) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

(2012) Marcus Fändrich   JOURNAL OF MOLECULAR BIOLOGY

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

(2012) David A. Hicks et al.   Frontiers in Physiology

Cholesterol Promotes the Interaction of Alzheimer β-Amyloid Monomer with Lipid Bilayer

(2011) Xiang Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide

(2011) Mark Taylor et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Effect of Alzheimer’s Aβ Aggregation State on the Permeation of Biomimetic Lipid Vesicles

(2010) Thomas L. Williams et al.   LANGMUIR

Fibril Fragmentation Enhances Amyloid Cytotoxicity

(2009) Wei-Feng Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

(2009) K. Vanommeslaeghe et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure and Orientational Texture of Self-Organizing Lipid Bilayers

(2009) E. B. Watkins et al.   PHYSICAL REVIEW LETTERS

Membrane-Thinning Effect of Curcumin

(2008) Wei-Chin Hung et al.   BIOPHYSICAL JOURNAL

The Bound States of Amphipathic Drugs in Lipid Bilayers: Study of Curcumin

(2008) Yen Sun et al.   BIOPHYSICAL JOURNAL

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-β peptide

(2008) Eva Y. Chi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE