Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines

A Single Stereodynamic Center Modulates the Rate of Self-Assembly in a Biomolecular System

(2015) Yitao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fine Tuning of β-Peptide Foldamers: a Single Atom Replacement Holds Back the Switch from an 8-Helix to a 12-Helix

(2015) Amandine Altmayer-Henzien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterogeneous H-Bonding in a Foldamer Helix

(2015) Brian F. Fisher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Straightforward Synthesis of Novel Enantiopure α-Trifluoromethylated Azetidine 2-Carboxylic Acid and Homoserines

(2015) Nathalie Lensen et al.   ORGANIC LETTERS

Synthesis and structure of oxetane containing tripeptide motifs

(2014) Nicola H. Powell et al.   CHEMICAL COMMUNICATIONS

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

Recent Advances in the Stereoselective Synthesis of Aziridines

(2014) Leonardo Degennaro et al.   CHEMICAL REVIEWS

Small Heterocycles in Multicomponent Reactions

(2014) Benjamin H. Rotstein et al.   CHEMICAL REVIEWS

Harnessing theortho-Directing Ability of the Azetidine Ring for the Regioselective and Exhaustive Functionalization of Arenes

(2014) Marina Zenzola et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Conformational Study of Model Peptides ContainingN-Substituted 3-Aminoazetidine-3-carboxylic Acids

(2014) Asta Žukauskaitė et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy

(2014) Dean P. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

A γ-Amino Acid That Favors 12/10-Helical Secondary Structure in α/γ-Peptides

(2014) Michael W. Giuliano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

(2014) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide

(2014) Laura Carroccia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Amine Protection/α-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation–Electrophilic Substitution

(2014) David M. Hodgson et al.   ORGANIC LETTERS

Generation and Electrophile Trapping of N-Boc-2-lithio-2-azetine: Synthesis of 2-Substituted 2-Azetines

(2014) David M. Hodgson et al.   ORGANIC LETTERS

Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine

(2014) Minsoo Han et al.   ACS Medicinal Chemistry Letters

Regioselective functionalization of 2-arylazetidines: evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent

(2013) Leonardo Degennaro et al.   CHEMICAL COMMUNICATIONS

α-Lithiation–Electrophile Trapping of N-Thiopivaloylazetidin-3-ol: Stereoselective Synthesis of 2-Substituted 3-Hydroxyazetidines

(2013) David M. Hodgson et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthetic Applications and Inversion Dynamics of Configurationally Stable 2-Lithio-2-arylpyrrolidines and -piperidines

(2012) Timothy K. Beng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of new functionalized aziridine-2- and azetidine-3-carboxylic acid derivatives of potential interest for biological and foldameric applications

(2011) Asta Žukauskaitė et al.   AMINO ACIDS

Asymmetric Synthesis of α-Chloro-β-amino-N-sulfinyl Imidates as Chiral Building Blocks

(2011) Filip Colpaert et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines

(2011) Gert Callebaut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Lithiation-Electrophilic Substitution of N-Thiopivaloylazetidine

(2010) David M. Hodgson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α,β-Aziridinylphosphonates by lithium amide-induced phosphonyl migration from nitrogen to carbon in terminal aziridines

(2010) David M Hodgson et al.   Beilstein Journal of Organic Chemistry

Enantioselective Syntheses of Morpholines and Their Homologues via SN2-Type Ring Opening of Aziridines and Azetidines with Haloalcohols

(2009) Manas K. Ghorai et al.   JOURNAL OF ORGANIC CHEMISTRY

BF3·OEt2-Mediated Highly Regioselective SN2-Type Ring-Opening ofN-Activated Aziridines andN-Activated Azetidines by Tetraalkylammonium Halides

(2009) Manas K. Ghorai et al.   JOURNAL OF ORGANIC CHEMISTRY

Novel Syntheses of Azetidines and Azetidinones

(2008) Alberto Brandi et al.   CHEMICAL REVIEWS

Azetidine-Derived Amino Acids versus Proline Derivatives. Alternative Trends in Reverse Turn Induction

(2008) José Luis Baeza et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Optically Active Arylaziridines by Regio- and Stereospecific Lithiation ofN-Bus-Phenylaziridine

(2008) Biagia Musio et al.   ORGANIC LETTERS