Alpha-ketoglutarate promotes alveolar bone regeneration by modulating M2 macrophage polarization

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

(2021) Jia-yuan Zhang et al.   CELL RESEARCH

Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions

(2021) Guillaume Hoeffel et al.   NATURE

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

(2021) Wei Qiao et al.   Nature Communications

Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

(2021) Dongqi An et al.   Redox Biology

Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling

(2020) Qiwen Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interspecies comparison of alveolar bone biology: Tooth extraction socket healing in mini pigs and mice

(2020) Jie Pan et al.   JOURNAL OF PERIODONTOLOGY

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

LepR-Expressing Stem Cells Are Essential for Alveolar Bone Regeneration

(2020) D. Zhang et al.   JOURNAL OF DENTAL RESEARCH

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury

(2020) Bisheng Zhou et al.   NATURE IMMUNOLOGY

Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system

(2020) Kim M. Summers et al.   PLOS BIOLOGY

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

(2019) Yilin Yu et al.   Cell Metabolism

Mesenchymal stem cell-macrophage crosstalk and bone healing

(2018) Jukka Pajarinen et al.   BIOMATERIALS

A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing

(2018) X. Yuan et al.   JOURNAL OF DENTAL RESEARCH

Ubiquitin‐specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling

(2018) Yu‐chen Guo et al.   EMBO JOURNAL

The oral microbiota: dynamic communities and host interactions

(2018) Richard J. Lamont et al.   NATURE REVIEWS MICROBIOLOGY

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs

(2017) Danielle A. Chisolm et al.   IMMUNITY

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

(2017) Lena Batoon et al.   BIOMATERIALS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The effects of immunomodulation by macrophage subsets on osteogenesis in vitro

(2016) Florence Loi et al.   Stem Cell Research & Therapy

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-12 inhibits TNF-α induced osteoclastogenesis via a T cell-independent mechanism in vivo

(2009) Masako Yoshimatsu et al.   BONE

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell