Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling

Deletion of Wnt5a in osteoclasts results in bone loss through decreased bone formation

(2020) Joseph L. Roberts et al.   Annals of the New York Academy of Sciences

Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma

(2020) Yanyun Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

USP34 Regulated Human Pancreatic Cancer Cell Survival via AKT and PKC Pathways

(2019) Zhiwei Gu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

Identification of recurrence marker associated with immune infiltration in prostate cancer with radical resection and build prognostic nomogram

(2019) Xin Rui et al.   BMC CANCER

Targeting deubiquitinase USP28 for cancer therapy

(2018) Xiaofang Wang et al.   Cell Death & Disease

Deubiquitinating Enzymes and Bone Remodeling

(2018) Yu-chen Guo et al.   Stem Cells International

Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

(2018) Yiwei Wang et al.   CELL RESEARCH

Ubiquitin‐specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling

(2018) Yu‐chen Guo et al.   EMBO JOURNAL

Discovery of a periosteal stem cell mediating intramembranous bone formation

(2018) Shawon Debnath et al.   NATURE

Recombinant growth differentiation factor 11 impairs fracture healing through inhibiting chondrocyte differentiation

(2018) Rixin Zheng et al.   Annals of the New York Academy of Sciences

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation

(2018) Hui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

(2017) Andrew P. Turnbull et al.   NATURE

AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs

(2017) Chen-chen Zhou et al.   Bone Research

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes

(2016) Adam H. Tencer et al.   BIOCHEMISTRY

Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice

(2016) Hwa Young Yim et al.   JOURNAL OF IMMUNOLOGY

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

(2016) Fumiaki Ohtake et al.   MOLECULAR CELL

GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

(2016) Weiqing Liu et al.   Nature Communications

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

(2015) Megan M Weivoda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

(2015) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34

(2013) Konstantinos Poalas et al.   Cell Communication and Signaling

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

Increased Osteopontin Contributes to Inhibition of Bone Mineralization in FGF23-Deficient Mice

(2013) Quan Yuan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks

(2013) S. M. H. Sy et al.   NUCLEIC ACIDS RESEARCH

NF-κB signaling and bone resorption

(2013) Y. Abu-Amer   OSTEOPOROSIS INTERNATIONAL

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho−/− Mice

(2012) Quan Yuan et al.   PLoS Genetics

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling

(2011) T. T. H. Lui et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of NF-κB in the skeleton

(2010) Deborah Veis Novack   CELL RESEARCH

Role of the A20-TRAF6 Axis in Lipopolysaccharide-mediated Osteoclastogenesis

(2010) Guillaume Mabilleau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Approaches to the targeting of treatment for osteoporosis

(2009) John A. Kanis et al.   Nature Reviews Rheumatology

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION