Article
Engineering, Biomedical
Andrew J. Ciciriello, Bapurao Surnar, Giovanni D. Medy, Xiaoyu Su, Shanta Dhar, Courtney M. Dumont
Summary: Drug delivery requires precision in timing, location, and dosage. To address the challenges in achieving therapeutic benefits, researchers have developed the BEACON platform, which utilizes an implantable biomaterial as a target for systemically delivered nanoparticles (NPs). The BEACON system has demonstrated temporal dexterity, decreased off-target accumulation, and retention of NPs in the target biomaterial, showing its broad applicability in improving targeted drug delivery.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Chao Ma, Bo Li, Jinrui Zhang, Yao Sun, Jingjing Li, Hangcheng Zhou, Jianlei Shen, Rui Gu, Jiangchao Qian, Chunhai Fan, Hongjie Zhang, Kai Liu
Summary: The nanotherapeutic formulations utilizing genetically engineered IL1ra protein complexes exhibit ultralong-lasting bioefficacy, significantly improving drug regimen for rheumatoid arthritis and potentially enhancing patient compliance with therapy.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Khalida Fakhruddin, Rozita Hassan, Muhammad Umar Aslam Khan, Sabrina Naula Allisha, Saiful Izwan Abd Razak, Maen Hussni Zreaqat, Hadafi Fitri Mohd Latip, Mohd Najeb Jamaludin, Anwarul Hassan
Summary: Halloysite nanotubes (HNTs), as a natural material, have unique properties that make them ideal for biomedical applications, such as loading bioactive molecules and therapeutic agents. The review paper covers the characterizations, properties, and applications of HNTs-polymer nanocomposites in biomedical fields, providing an overview of their potential in personalized medicine and drug delivery methods for researchers developing novel biomaterials in biomedical engineering and health care.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Engineering, Biomedical
X. Huang, D. He, Z. Pan, G. Luo, J. Deng
Summary: ROS can mediate various physiological functions, but their over-accumulation can lead to premature aging or death, as well as inflammatory conditions. Advances in nanoscience have led to the development of nanomaterials with unique ROS-scavenging abilities, allowing for the emergence of next-generation strategies to ameliorate ROS-related inflammatory conditions. Ongoing studies and clinical applications of nanomedicine based on ROS scavenging stand to benefit from this interdisciplinary field.
MATERIALS TODAY BIO
(2021)
Review
Biochemistry & Molecular Biology
Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: The treatment of bone defects is a major challenge in modern clinical practice due to the increased incidence of bone disease. Biomaterials play a crucial role in bone tissue engineering and their selection is a key issue in designing tissue scaffolds for patient-specific regeneration. This article provides a comprehensive literature review of existing and novel biomaterials, highlighting their advantages and disadvantages for bone defect regeneration. The materials are categorized into organic, inorganic, and synthetic polymers, considering current trends in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Prachi Desai, Anshuman Dasgupta, Alexandros Marios Sofias, Quim Pena, Robert Goestl, Ioana Slabu, Ulrich Schwaneberg, Thomas Stiehl, Wolfgang Wagner, Stefan Jockenhoevel, Julia Stingl, Rafael Kramann, Christian Trautwein, Tim H. Bruemmendorf, Fabian Kiessling, Andreas Herrmann, Twan Lammers
Summary: Drug delivery systems (DDS) control drug availability and activity to achieve a balance between therapeutic efficacy and side effects. They overcome biological barriers encountered by drug molecules and are explored for modulating host-material interfaces. This article provides an overview of barriers and interfaces encountered by DDS in different administration routes and highlights material engineering advances for improved disease treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Ali Mahnavi, Mina Shahriari-Khalaji, Bahareh Hosseinpour, Mostafa Ahangarian, Amir Aidun, Simona Bungau, Syed Shams ul Hassan
Summary: Different biomaterials and methods have been used in tissue engineering for repairing damaged bones. However, the weakness in cellular activity or osteoconductivity sometimes limits their optimal use. To address this issue, surface modification techniques, such as polydopamine coating, have been employed. Polydopamine not only covers the weakness of scaffolds but also enhances their osteoconductivity. The hydrophilic layer created by polydopamine allows bone cells to anchor and adhere well to the surfaces, while the catechol and amine groups make the surfaces chemically active, resulting in increased osteoconductivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Jan P. Stegemann, William R. Wagner, Uta Goebel, Ekaterina Perets, Kam W. Leong, J. Kent Leach, Jeremy Gilbert
Summary: This article collects contributions from the editors of six leading journals in the field of biomaterials science and engineering, highlighting specific advances, topics, and trends in the publications of each journal in 2022. It provides a global perspective on various material types, functionalities, and applications. The highlighted topics include a diverse range of biomaterials, fabrication techniques, and applications in different areas such as drug delivery, tissue engineering, and cancer treatment.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Environmental
Meng Luo, Dagogo Dorothy Winston, Wen Niu, Yidan Wang, Hongyang Zhao, Xiaoyan Qu, Bo Lei
Summary: The study presented a multifunctional bioactive therapeutics-repair-enabled citrate-iron hydrogel scaffold that can inhibit tumor recurrence and promote wound repair simultaneously, showing great potential in clinical applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj, Rajamanikkam Yuvashree, Gopal Hariprabu, Raghunandhakumar Subramanian, Palraju Murali, Deepak Nallaswamy Veeraiyan, Lakshmi Thangavelu
Summary: Zebrafish serves as an excellent biomaterial testing platform for rapid characterization of the biological properties of new biomaterials, particularly in bone tissue engineering applications, surpassing technical difficulties and cost issues associated with rodent models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Tamara Birman, Dror Seliktar
Summary: Balancing between chemical and biological functionality is crucial to achieve injectability in hydrogels through specific crosslinking pathways, while maintaining cell compatibility. With the emergence of new injectable biosynthetic materials, their impact in cell therapy and bioprinting is becoming increasingly significant.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Junzhi Yi, Qi Liu, Qin Zhang, Ting Gang Chew, Hongwei Ouyang
Summary: Biomaterials are essential for tissue engineering, but current materials have limitations. Modular protein engineering-based (MPE) biomaterials have been developed due to their sequence-tunable property. The sequence of MPE biomaterials plays a crucial role in their functionality and performance in skeletal tissue repair. This review provides a comprehensive overview of skeletal tissue engineering using MPE biomaterials.
Article
Materials Science, Multidisciplinary
Meng Luo, Konstantin Shaitan, Xiaoyan Qu, Anton P. Bonartsev, Bo Lei
Summary: Rare earth-based biomaterials possess representative optical/magnetic properties and special biological properties, which make them potential candidates for wound healing and skin tissue regeneration. Inorganic-organic hybrid rare earth-based biomaterials demonstrate promising applications in wound healing and repair.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Biomedical
Xiao Sheng, Chen Li, Zhonghan Wang, Yu Xu, Yang Sun, Weimin Zhang, He Liu, Jincheng Wang
Summary: This review provides a comprehensive overview of strontium-containing biomaterials and their current clinical use. Different types of biomaterials, including calcium phosphate, bioactive glass, and polymers, are discussed, and future outlook on the fabrication of the next-generation multifunctional and smart biomaterials is provided.
MATERIALS TODAY BIO
(2023)
Review
Engineering, Biomedical
Leila Daneshmandi, Mohammed Barajaa, Armin Tahmasbi Rad, Stefanie A. Sydlik, Cato T. Laurencin
Summary: Graphene and its derivatives have attracted global attention for their unique characteristics, especially in the field of biomedical applications. This review article comprehensively explores the usage of graphene-based materials in bone regenerative engineering, discussing their applications as fillers in composites, coatings for scaffolds and implants, and delivery vehicles for therapeutic agents. The safety, biocompatibility, and future prospects of graphene materials in regenerative engineering are also evaluated.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Ceramics
Mehdi Chougan, Francesca Romana Lamastra, Daniela Caschera, Saulius Kaciulis, Eleonora Bolli, Claudia Mazzuca, Seyed Hamidreza Ghaffar, Mazen J. Al-Kheetan, Giampiero Montesperelli, Alessandra Bianco
Summary: There is a growing interest in using nanosized fillers, such as graphene oxide (GO), in cement-based construction materials to enhance mechanical properties. The interaction between GO and cement can significantly improve the macroproperties of cement. A GO water suspension was selected for its reproducibility and environmental safety. Various tests, including morphological characterization and mechanical property evaluation, were performed on samples with different dosages of GO. Results showed that an extra-low dosage of GO (0.01%) exhibited the most promising enhancement in mechanical strength.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Eleonora Bolli, Saulius Kaciulis, Alessio Mezzi, Roberto Montanari, Alessandra Varone
Summary: In this study, the distribution of Al oxide and its comparison with commercial foils were investigated in different thicknesses of high purity Al thin foils. The results showed that the oxide layer on the high purity samples was thicker than that on the commercial quality samples, and the thinnest foils had the thinnest oxide layer. Furthermore, considering the size effect, the mechanical properties of thin foils improved as the thickness decreased. The complex morphology of the metal-oxide interface contributed to enhancing the mechanical performances of Al foils with a thickness below 50 μm.
SURFACE AND INTERFACE ANALYSIS
(2023)
Article
Chemistry, Physical
Pietro Ausiello, Eleonora Bolli, Saulius Kaciulis, Antonio Gloria, Antonio Lanzotti, Massimo Martorelli, Alessio Mezzi, Roberto Montanari, Maria Richetta, Alessandra Varone
Summary: Titanium and its alloys are commonly used in commercial dental devices. This study investigated the surface morphology and chemical composition of different commercial dental implants through scanning electron microscopy and X-ray photoelectron spectroscopy. The results revealed common features and differences among the implants, as well as the presence of metal oxides on their surfaces.
SURFACE AND INTERFACE ANALYSIS
(2023)
Article
Chemistry, Physical
V. Ambrogi, E. Bolli, M. Ceccarelli, S. Kaciulis, A. Mezzi, R. Montanari, E. Pakhomova, M. Richetta, A. Varone
Summary: Internal prosthesis and grafts are commonly made of Ti alloys, stainless steels, and Co-Cr alloys. However, they have drawbacks in terms of mechanical properties and the need for secondary surgery. Biodegradable Mg alloys have gained attention due to their compatibility with the body and good mechanical properties similar to human bones. This study analyzed the surface modifications of a biodegradable AZ31 alloy after immersion in a physiological solution for 15 days using XPS, XRD, and SEM. The results showed a presence of MgO on the alloy surface and the detection of Mg(OH)2 after immersion.
SURFACE AND INTERFACE ANALYSIS
(2023)
Article
Chemistry, Physical
Eleonora Bolli, Alessio Mezzi, Saulius Kaciulis, Valerio Serpente, Alessandro Bellucci, Daniele M. Trucchi
Summary: Thin films of barium fluoride (BaFx) were deposited on gallium arsenide and silicon to serve as possible candidates for photovoltaic (PV) anodes in hybrid thermionic devices. X-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS) were used to analyze the chemical and physical properties of these films at temperatures up to 300 degrees C. It was found that the reduction in work function of the PV anodes was correlated with the thermal desorption of contaminants in the BaFx coatings.
SURFACE AND INTERFACE ANALYSIS
(2023)
Article
Chemistry, Physical
Alessandro Di Michele, Morena Nocchetti, Donatella Pietrella, Loredana Latterini, Giulia Quaglia, Ilaria Mattu, Giuseppina Padeletti, Saulius Kaciulis, Eleonora Bolli, Valeria Ambrogi
Summary: This paper describes a sustainable, ultrasound-assisted method using citrate as a reducing agent to prepare silver@hydroxyapatite functionalized calcium carbonate composites. The composites obtained using citrate as the reducing agent showed the best performance in terms of nanoparticle nature, antimicrobial activity, and cytotoxic activity.
Article
Chemistry, Multidisciplinary
Ayessa P. Maciel, Guilherme Gomide, Franciscarlos G. da Silva, Ana Alice A. M. Guerra, Jerome Depeyrot, Alessio Mezzi, Alex F. C. Campos
Summary: This paper focuses on the fabrication, characterization, and application of ferrite-based magnetic nanoparticles functionalized with L-lysine as potential nanoadsorbents to remove acetylsalicylic acid (ASA) from water. The results show that these nanoadsorbents can efficiently remove ASA from water and have the characteristics of reusability.
Article
Energy & Fuels
Alessandro Bellucci, Stefano Orlando, Luca Medici, Antonio Lettino, Alessio Mezzi, Saulius Kaciulis, Daniele Maria Trucchi
Summary: Pulsed laser deposition with ultra-short laser beam was used to grow nanostructured thin films of lead telluride (PbTe) for thermoelectric applications. Silver (Ag) was added to PbTe at different percentages, and the surface morphology, chemical composition, and structural characteristics were analyzed. Electrical resistivity measurements showed semiconductor behavior for most samples, while Seebeck coefficient measurements indicated n-type doping. The power factor values were competitive and suitable for low-power applications on flexible substrates.
Article
Chemistry, Multidisciplinary
Alessio Mezzi, Eleonora Bolli, Saulius Kaciulis, Alessandro Bellucci, Barbara Paci, Amanda Generosi, Matteo Mastellone, Valerio Serpente, Daniele Maria Trucchi
Summary: Thin films of scandium oxide (Sc2O3) were deposited on silicon substrates to study the effect of thickness on work function reduction. Various measurements, including X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), energy dispersive X-ray reflectivity (EDXR), atomic force microscopy (AFM), and ultraviolet photoelectron spectroscopy (UPS), were performed on the films of different nominal thicknesses (ranging from 2-50 nm) and in multi-layered mixed structures with barium fluoride (BaF2) films. The results showed that non-continuous films were necessary to minimize the work function, even with a stoichiometry far from ideal (Sc/O = 0.38), due to the formation of surface dipole effects between crystalline islands and substrates. Furthermore, the presence of BaF2 in multi-layered films did not contribute to further work function reduction.
Article
Virology
Giulia Gatti, Martina Brandolini, Andrea Mancini, Francesca Taddei, Silvia Zannoli, Giorgio Dirani, Martina Manera, Valentina Arfilli, Agnese Denicolo, Anna Marzucco, Maria Sofia Montanari, Irene Zaghi, Massimiliano Guerra, Rita Tennina, Maria Michela Marino, Laura Grumiro, Monica Cricca, Vittorio Sambri
Summary: Since the first SARS-CoV-2 outbreak, mutations have changed the viral genome sequence, structure, and protein folding, leading to the onset of new variants. These alterations challenge both the clinical field and diagnostic demand due to detection failures and incomplete PCR results. Analyzing understudied genes such as N and investigating regions prone to mutation through WG-NGS can help identify new or reacquired mutations for designing robust primers.
Article
Chemistry, Physical
Jacopo Cardellini, Arianna Balestri, Luca Comparini, Barbara Lonetti, Marco Brucale, Francesco Valle, Debora Berti, Costanza Montis
Summary: The interaction between citrate-coated gold nanoparticles (AuNPs) and hybrid membranes made of lipid and copolymer was investigated. The results showed that the incorporation of copolymer promoted AuNPs clustering, and the size and morphology of AuNPs clusters could be controlled in non-homogeneous membranes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Cell Biology
Estefania Lozano-Andres, Agustin Enciso-Martinez, Abril Gijsbers, Andrea Ridolfi, Guillaume Van Niel, Sten F. W. M. Libregts, Claudio Pinheiro, Martijn J. C. van Herwijnen, An Hendrix, Marco Brucale, Francesco Valle, Peter J. Peters, Cees Otto, Ger J. A. Arkesteijn, Marca H. M. Wauben
Summary: Extracellular vesicles (EVs) in blood plasma have potential as biomarkers for disease. However, analyzing EVs at the single particle level is challenging due to the complexity of plasma. This study investigates the presence and formation of EV-lipoproteins particles (LPPs) complexes, and the impact of LPPs on EV analysis and biomarker profiling. The results demonstrate that EV-LPP complexes can form under physiological conditions, and the presence of LPPs can influence the quantitative and qualitative analysis of EVs.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
