Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs

UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma

(2015) Haiyan Dong et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis, in vitro antimicrobial and cytotoxic activities of new carbazole derivatives of ursolic acid

(2015) Wen Gu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis

(2015) Jichuang Wang et al.   Scientific Reports

Design and synthesis of novel 2H-chromen-2-one derivatives bearing 1,2,3-triazole moiety as lead antimicrobials

(2014) Khushbu Kushwaha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of 4-oxoquinoline-3-carboxamides derivatives as potent anti-fibrosis agents

(2014) Jun Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A New Synthetic Ursolic Acid Derivative IUA with Anti-Tumor Efficacy Against Osteosarcoma Cells via Inhibition of JNK Signaling Pathway

(2014) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

QSAR Guided Semi-synthesis and In-Vitro Validation of Anticancer Activity in Ursolic Acid Derivatives

(2014) Komal Kalani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Drug Targets for Cell Cycle Dysregulators in Leukemogenesis: In Silico Docking Studies

(2014) Archana Jayaraman et al.   PLoS One

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

(2013) Muthu K. Shanmugam et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety

(2012) Ming-Chuan Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives

(2011) Jing-Wei Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ultra-fast FFT protein docking on graphics processors

(2010) David W. Ritchie et al.   BIOINFORMATICS

Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species

(2009) Huang-Yao Tu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines

(2009) Sheng-lei Yan et al.   TOXICOLOGY IN VITRO

Endogenous reverse transcriptase as a mediator of ursolic acid’s anti-proliferative and differentiating effects in human cancer cell lines

(2008) Irene Bonaccorsi et al.   CANCER LETTERS