Coumarin: A Privileged Scaffold for the Design and Development of Antineurodegenerative Agents

Coumarin hybrids as novel therapeutic agents

(2014) Sonali Sandhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TS-Chemscore, a Target-Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening

(2014) Wen-Jing Wang et al.   Chemical Biology & Drug Design

Coumarin derivatives: an updated patent review (2012 – 2014)

(2014) Anna-Maria Katsori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anti-Inflammatory Effects of α-Galactosylceramide Analogs in Activated Microglia: Involvement of the p38 MAPK Signaling Pathway

(2014) Yeon-Hui Jeong et al.   PLoS One

Cardiotonic pill attenuates white matter and hippocampal damage via inhibiting microglial activation and downregulating ERK and p38 MAPK signaling in chronic cerebral hypoperfused rat

(2013) Ki Mo Lee et al.   BMC Complementary and Alternative Medicine

Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway

(2013) X.Y. Song et al.   NEUROSCIENCE

Synthesis and in vitro antitumor activity of novel scopoletin derivatives

(2012) Wukun Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarin-based drugs: a patent review (2008 – present)

(2012) Christos Kontogiorgis et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice

(2012) Chen Wang et al.   JOURNAL OF NEUROCHEMISTRY

Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons

(2012) Li Yan et al.   Neuroscience Bulletin

Synthesis and In-Vitro Antimycobacterial Activity of Fluoroquinolone Derivatives Containing a Coumarin Moiety

(2011) Qiang Guo et al.   ARCHIV DER PHARMAZIE

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships for naturally occurring coumarins as β-secretase inhibitor

(2011) Shinsuke Marumoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydroxycoumarins as selective MAO-B inhibitors

(2011) Silvia Serra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer Effects of Imperatorin Isolated from Angelica dahurica: Induction of Apoptosis in HepG2 Cells through both Death-Receptor- and Mitochondria-Mediated Pathways

(2011) Ke-wang Luo et al.   CHEMOTHERAPY

Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Participate in Anti-inflammatory Activity of Imperatorin from Glehnia littoralis

(2011) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neurodegenerative diseases and neuroprotection: current views and prospects

(2011) André Nieoullon   Journal of Applied Biomedicine

The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory

(2011) A. Hornick et al.   NEUROSCIENCE

Inhibitory Effects of Coumarins from the Stem Barks of Fraxinus rhynchophylla on Adipocyte Differentiation in 3T3-L1 Cells

(2010) Eunjin Shin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

(2010) Leonardo Pisani et al.   ChemMedChem

Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats

(2010) Hakkı Murat Bilgin et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Synthesis, Stereochemical Separation, and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines

(2010) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species

(2009) So-hyung Kim et al.   ACTA PHARMACOLOGICA SINICA

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors

(2009) Maria Joao Matos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An in vitro screening cascade to identify neuroprotective antioxidants in ALS

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Antimicrobial and Antioxidant Activities of Coumarins from the Roots of Ferulago campestris (Apiaceae)

(2009) Adriana Basile et al.   MOLECULES

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

(2008) C. Anderle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

(2008) Francesco Leonetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

(2008) Vincenzo Tumiatti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

HPLC analysis and safety assessment of coumarin in foods

(2008) Constanze Sproll et al.   FOOD CHEMISTRY

Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B Inhibitors

(2008) Lourdes Santana et al.   JOURNAL OF MEDICINAL CHEMISTRY

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

(2007) Lorna Piazzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY