Molecular phenotyping of a UK population: defining the human serum metabolome

A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions

(2013) Helen L Kotze et al.   BMC Systems Biology

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

(2013) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it

(2013) Douglas B. Kell   FEBS Journal

Metabolomic markers reveal novel pathways of ageing and early development in human populations

(2013) Cristina Menni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An analysis of a ‘community-driven’ reconstruction of the human metabolic network

(2013) Neil Swainston et al.   Metabolomics

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

The Human Urine Metabolome

(2013) Souhaila Bouatra et al.   PLoS One

Human serum metabolic profiles are age dependent

(2012) Zhonghao Yu et al.   AGING CELL

Metabolomic study of plasma of patients with abdominal aortic aneurysm

(2012) Francisco J. Rupérez et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Redox Proteomics: Chemical Principles, Methodological Approaches and Biological/Biomedical Promises

(2012) Angela Bachi et al.   CHEMICAL REVIEWS

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

(2012) Susan Cheng et al.   CIRCULATION

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

(2012) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy

(2012) Jeremy K Nicholson et al.   Expert Opinion on Drug Metabolism & Toxicology

The Prevalence of Metabolic Syndrome in Children: A Systematic Review of the Literature

(2012) Amanda Friend et al.   Metabolic Syndrome and Related Disorders

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

(2012) Jianguo Xia et al.   Metabolomics

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

MetaboLights—an open-access general-purpose repository for metabolomics studies and associated meta-data

(2012) Kenneth Haug et al.   NUCLEIC ACIDS RESEARCH

The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans

(2012) Warwick B Dunn et al.   Bioanalysis

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

(2011) M. Brown et al.   BIOINFORMATICS

Feasibility of Identifying Pancreatic Cancer Based on Serum Metabolomics

(2011) O. F. Bathe et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses

(2011) John P. A. Ioannidis   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Human metabolic profiles are stably controlled by genetic and environmental variation

(2011) G. Nicholson et al.   Molecular Systems Biology

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

(2011) Warwick B Dunn et al.   Nature Protocols

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

(2010) Warwick B. Dunn et al.   CHEMICAL SOCIETY REVIEWS

Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease: INTERMAP Study

(2010) Ivan K. S. Yap et al.   JOURNAL OF PROTEOME RESEARCH

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

(2009) M. Brown et al.   ANALYST

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

(2009) Paul Begley et al.   ANALYTICAL CHEMISTRY

Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum

(2009) Eva Zelena et al.   ANALYTICAL CHEMISTRY

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Plasma 25-Hydroxyvitamin D Concentration and Metabolic Syndrome Among Middle-Aged and Elderly Chinese Individuals

(2009) L. Lu et al.   DIABETES CARE

Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

(2009) David M Lee et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Common and Unique Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence and Smoking Cessation

(2009) Ju Wang et al.   NEUROPSYCHOPHARMACOLOGY

Human metabolic phenotype diversity and its association with diet and blood pressure

(2008) Elaine Holmes et al.   NATURE

Analysis of the adult human plasma metabolome

(2008) Kay A Lawton et al.   PHARMACOGENOMICS

A pilot study of GC/MS-based serum metabolic profiling of acute rejection in renal transplantation

(2008) You-ying Mao et al.   TRANSPLANT IMMUNOLOGY