Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics

Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesiclesin vivo

(2015) Joseph A. White et al.   HUMAN MOLECULAR GENETICS

Okadaic acid: a tool to study regulatory mechanisms for neurodegeneration and regeneration in Alzheimer′s disease

(2015) PradipKumar Kamat et al.   Neural Regeneration Research

Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study

(2015) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility

(2015) Feng J. Gao et al.   TRAFFIC

Interaction of SQSTM1 with the motor protein dynein - SQSTM1 is required for normal dynein function and trafficking

(2014) L. Calderilla-Barbosa et al.   JOURNAL OF CELL SCIENCE

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

(2014) Kyoko Chiba et al.   MOLECULAR BIOLOGY OF THE CELL

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases

(2014) Min Jung Kang et al.   PLoS One

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice

(2014) Michael P Nelson et al.   Acta Neuropathologica Communications

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport

(2013) Kunsang Dolma et al.   HUMAN MOLECULAR GENETICS

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo

(2013) Shermali Gunawardena et al.   HUMAN MOLECULAR GENETICS

Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells

(2013) SYU-ICHI KANNO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

(2013) G. Liot et al.   JOURNAL OF NEUROSCIENCE

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

(2013) Georgios Kallifatidis et al.   Marine Drugs

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

(2013) Andrew M. Hau et al.   PLoS One

Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata

(2013) T. E. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

(2012) Yaping Chu et al.   BRAIN

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

(2012) Jessica J. Field et al.   CHEMISTRY & BIOLOGY

Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation

(2012) Viswanath Das et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Therapeutic strategies for tau mediated neurodegeneration

(2012) Y. Yoshiyama et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

(2012) Gerald F. Reis et al.   MOLECULAR BIOLOGY OF THE CELL

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model

(2012) Petra Füger et al.   PLoS Genetics

Advances in the Pathogenesis of Alzheimer’s Disease: Focusing on Tau-Mediated Neurodegeneration

(2012) Yale Duan et al.   Translational Neurodegeneration

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

(2011) Angeles Canales et al.   ACS Chemical Biology

Exome Sequencing Identifies a DYNC1H1 Mutation in a Large Pedigree with Dominant Axonal Charcot-Marie-Tooth Disease

(2011) Michael N. Weedon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles

(2011) Sandra E. Encalada et al.   CELL

Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

(2011) C Crimella et al.   CLINICAL GENETICS

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array

(2011) Martin Schuster et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases

(2010) H. Sudo et al.   HUMAN MOLECULAR GENETICS

Microtubule-Stabilizing Drugs from Marine Sponges: Focus on Peloruside A and Zampanolide

(2010) John H. Miller et al.   Marine Drugs

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

DCTN1 mutations in Perry syndrome

(2009) Matthew J Farrer et al.   NATURE GENETICS

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Dynactin Subunit p150Glued Isoforms Notable for Differential Interaction with Microtubules

(2009) Olga N. Zhapparova et al.   TRAFFIC

Action in the axon: generation and transport of signaling endosomes

(2008) Katharina E Cosker et al.   CURRENT OPINION IN NEUROBIOLOGY

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Bunina bodies in amyotrophic lateral sclerosis

(2008) Koichi Okamoto et al.   NEUROPATHOLOGY

Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons

(2008) Seung Yong Yoon et al.   NEUROSCIENCE LETTERS

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics

(2008) Nobutaka Hirokawa et al.   PHYSIOLOGICAL REVIEWS

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

(2008) Wei-Lien Yen et al.   PHYSIOLOGY

(+)-Discodermolide: total synthesis, construction of novel analogues, and biological evaluation

(2007) Amos B. Smith et al.   TETRAHEDRON