Article
Medicine, General & Internal
Makoto Saito, Verena I. Carrara, Mary Ellen Gilder, Aung Myat Min, Nay Win Tun, Mupawjay Pimanpanarak, Jacher Viladpai-nguen, Moo Kho Paw, Warat Haohankhunnatham, Kamonchanok Konghahong, Aung Pyae Phyo, Cindy Chu, Claudia Turner, Sue J. Lee, Jureeporn Duanguppama, Mallika Imwong, Germana Bancone, Stephane Proux, Pratap Singhasivanon, Nicholas J. White, Francois Nosten, Rose McGready
Summary: The study found that in the Greater Mekong Subregion, dihydroartemisinin-piperaquine and artesunate-mefloquine provided longer recurrence-free intervals. DP was well tolerated and safe, and was the only drug providing satisfactory efficacy for pregnant women infected with Plasmodium falciparum in this area.
Review
Genetics & Heredity
Mukul Rawat, Abhishek Kanyal, Deepak Choubey, Bhagyashree Deshmukh, Rashim Malhotra, D. Mamatharani, Anjani Gopal Rao, Krishanpal Karmodiya
Summary: This study investigates the genetic and transcriptomic features of artemisinin-resistant parasites. The research identifies mutations in genes such as Kelch13 as molecular markers of resistance. The study also explores the deregulation of key biological pathways in resistant parasites. These findings provide important insights for further research on artemisinin resistance.
FRONTIERS IN GENETICS
(2022)
Article
Microbiology
Weijia Cheng, Wei Wang, Huiyin Zhu, Xiaonan Song, Kai Wu, Jian Li
Summary: Rapid detection of single nucleotide polymorphisms (SNPs) is crucial for malaria treatment. A platform based on allele-specific PCR (AS-PCR) and lateral flow assay (LFA) was developed and evaluated for accurate SNP detection of pfmdr1. It offers a useful tool to identify antimalarial drug resistance and can support the effort to eliminate malaria globally.
MICROBIOLOGY SPECTRUM
(2022)
Review
Chemistry, Medicinal
Christopher M. Woodley, Patricia S. M. Amado, Maria L. S. Cristiano, Paul M. O'Neill
Summary: Recent research has highlighted the need for fully synthetic endoperoxide-based antimalarials due to the rise of resistance to artemisinin in Southeast Asia and the synthetic limitations of the artemisinin scaffold. Various synthetic endoperoxide antimalarials utilizing different endoperoxide warheads have been explored, with two classes - 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes - showing promise and still actively being developed.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Infectious Diseases
Navaporn Posayapisit, Jutharat Pengon, Philip J. Shaw, Chairat Uthaipibull, Darin Kongkasuriyachai, Aung Pyae Phyo, Francois Nosten, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
Summary: The effectiveness of antimalarial drug P218 against artemisinin-resistant Plasmodium falciparum is still uncertain, despite its efficacy against other drug-resistant parasites.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Lucie Paloque, Romain Coppee, Barbara H. Stokes, Nina F. Gnadig, Karamoko Niare, Jean-Michel Augereau, David A. Fidock, Jerome Clain, Francoise Benoit-Vical
Summary: This study demonstrates that the propeller domain is not the sole mediator of PfK13-mediated artemisinin resistance, highlighting the importance of monitoring for mutations throughout PfK13. The P413A mutation in the BTB/POZ domain upstream of the propeller domain is sufficient to confer in vitro artemisinin resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Shaoqin Zheng, Yuan Liang, Zhaojia Wang, Min Liu, Yingyi Chen, Ying Ai, Wenfeng Guo, Guoming Li, Yueming Yuan, Zhiyong Xu, Wanting Wu, Xinan Huang, Zhibing Wu, Qin Xu, Jianping Song, Changsheng Deng
Summary: Artemisinin-based combination therapies (ACTs) are first-line antimalarial drugs. However, the emergence of resistance to ACTs in Plasmodium falciparum is a concern. This study successfully produced artemisinin-and piperaquine-resistant P. berghei K173 strains and explored the relationship between PfK13 and artemisinin resistance through DNA sequencing.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Infectious Diseases
Noreen Noreen, Asad Ullah, Syed Muhammad Salman, Yahia Mabkhot, Abdulrhman Alsayari, Syed Lal Badshah
Summary: Plasmodium falciparum, the causative agent of malaria, has developed resistance to multiple drugs, including the latest drug artemisinin. This resistance undermines the effectiveness of current treatment strategies, posing a threat to global efforts in malaria elimination. Research has identified genetic factors and molecular pathways associated with artemisinin resistance, highlighting the need for novel strategies to combat the spread of resistant parasites.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Microbiology
Yu Si, Weilin Zeng, Na Li, Chengqi Wang, Faiza Siddiqui, Jie Zhang, Liang Pi, Xi He, Luyi Zhao, Siqi Wang, Hui Zhao, Xinxin Li, Qi Yang, Jun Miao, Zhaoqing Yang, Liwang Cui
Summary: Plasmodium falciparum in the Greater Mekong subregion has developed resistance to antimalarial therapy. Evaluation of parasite isolates collected at the China-Myanmar border revealed varying levels of piperaquine susceptibility and identified potential genetic mutations associated with decreased drug effectiveness. Further research is needed to understand the mechanisms of piperaquine resistance and ongoing surveillance is crucial.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Editorial Material
Biology
Colin Sutherland, Didier Menard
Summary: A tool that analyzes the genome of parasites in the blood of malaria patients can assist policymakers in making informed decisions on how to address the increase in drug-resistant infections.
Article
Biology
Barbara H. Stokes, Satish K. Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F. Gnadig, Ioanna Deni, Kyra A. Schindler, Jade R. Bath, Kurt E. Ward, Josefine Striepen, Tomas Yeo, Leila S. Ross, Eric Legrand, Frederic Ariey, Clark H. Cunningham, Issa M. Souleymane, Adama Gansane, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M. Kabanywanyi, Aline Uwimana, Samuel J. Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, Francois Nosten, Timothy J. C. Anderson, Philip J. Rosenthal, Didier Menard, David A. Fidock
Summary: K13-mediated artemisinin resistance is becoming more prevalent in Southeast Asia and Africa, with mutations like R561 H and C580Y causing varying levels of resistance and fitness costs in malaria parasites. These findings highlight the complex interplay between K13 mutations, parasite survival, growth, and the genetic background in the spread of artemisinin resistance.
Article
Microbiology
Amuza Byaruhanga Lucky, Chengqi Wang, Ahmad Rushdi Shakri, Mohammad Kalamuddin, Anongruk Chim-Ong, Xiaolian Li, Jun Miao
Summary: This study demonstrates the critical role of PfGCN5 gene in stress responses of Plasmodium falciparum, indicating its potential as a target for malaria intervention.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Najia Karim Ghanchi, Bushra Qurashi, Hadiqa Raees, Mohammad Asim Beg
Summary: The study describes single nucleotide polymorphisms in the Kelch protein propeller domain of Plasmodium falciparum associated with artemisinin resistance in Southern Pakistan. All isolates analyzed for k13 propeller allele were observed as wild-type post implementation of ACT in Pakistan. Known variants associated with reduced susceptibility to artemisinin-based combination therapy (ACT) were not found, indicating favorable conditions for anti-malarial efficacy in the region.
Article
Medicine, General & Internal
Harvie P. Portugaliza, H. Magloire Natama, Pieter Guetens, Eduard Rovira-Vallbona, Athanase M. Some, Aida Millogo, D. Florence Ouedraogo, Innocent Valea, Hermann Sorgho, Halidou Tinto, Nguyen Van Hong, Antonio Sitoe, Rosauro Varo, Quique Bassat, Alfred Cortes, Anna Rosanas-Urgell
Summary: The study found that in most infections from African cohorts, increased expression of pfap2-g and other sexual ring biomarkers was observed after treatment. The estimated parasite age at the time of treatment was negatively correlated with the increase in pfap2-g transcript levels, suggesting that younger parasites are less susceptible to stimulation of sexual conversion.
Letter
Immunology
Charles J. Woodrow, Caterina Fanello
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Infectious Diseases
Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth A. Ashley, Arjen M. Dondorp, Nicholas J. White, Dyann Wirth, Rick Fairhurst, Sarah K. Volkman
Article
Infectious Diseases
Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W. F. Kingston, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Abul Faiz, Nicholas M. Anstey, Nicholas P. J. Day, Md. Amir Hossain, Mallika Imwong, Arjen M. Dondorp, Charles J. Woodrow
Article
Infectious Diseases
Ingfar Soontarawirat, Chiara Andolina, Richard Paul, Nicholas P. J. Day, Francois Nosten, Charles J. Woodrow, Mallika Imwong
Review
Medicine, General & Internal
Elizabeth A. Ashley, Aung Pyae Phyo, Charles J. Woodrow
Article
Multidisciplinary Sciences
Selina Bopp, Pamela Magistrado, Wesley Wong, Stephen F. Schaffner, Angana Mukherjee, Pharath Lim, Mehul Dhorda, Chanaki Amaratunga, Charles J. Woodrow, Elizabeth A. Ashley, Nicholas J. White, Arjen M. Dondorp, Rick M. Fairhurst, Frederic Ariey, Didier Menard, Dyann F. Wirth, Sarah K. Volkman
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
I. Sinha, C. J. Woodrow
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Benjamas Intharabut, Hugh W. Kingston, Ketsanee Srinamon, Elizabeth A. Ashley, Mallika Imwong, Mehul Dhorda, Charles Woodrow, Kasia Stepniewska, Kamolrat Silamut, Nicholas P. J. Day, Arjen M. Dondorp, Nicholas J. White, Abul Faiz, Pharath Lim, Rick Fairhurst, Chea Nguon, Steffen Borrmann, Mayfong Mayxay, Ye Htut, Olugbenga A. Mokuolu, Marie Onyamboko, Caterina Fanello, Francois Nosten, Sasithon Pukrittayakamee, Rupam Tripura, Tran Tinh Hien
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Cell Biology
James A. Watson, Sophie Uyoga, Perpetual Wanjiku, Johnstone Makale, Gideon M. Nyutu, Neema Mturi, Elizabeth C. George, Charles J. Woodrow, Nicholas P. J. Day, Philip Bejon, Robert O. Opoka, Arjen M. Dondorp, Chandy C. John, Kathryn Maitland, Thomas N. Williams, Nicholas J. White
Summary: Severe malaria caused by Plasmodium falciparum is difficult to accurately diagnose in children in high-transmission settings. A combination of platelet count and plasma PfHRP2 concentration can be used to identify severe falciparum malaria in severely ill patients. About one-third of children enrolled in clinical studies of severe malaria in high-transmission settings in Africa had other causes of their severe illness.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Bronwen E. Warner, Charles J. Woodrow, Aparna Pal
Review
Microbiology
Charles J. Woodrow, Nicholas J. White
FEMS MICROBIOLOGY REVIEWS
(2017)
Article
Public, Environmental & Occupational Health
Ghulam Rahim Awab, Mallika Imwong, Germana Bancone, Atthanee Jeeyapant, Nicholas P. J. Day, Nicholas J. White, Charles J. Woodrow
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
Letter
Microbiology
Rob W. van der Pluijm, James Watson, Charles J. Woodrow
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Infectious Diseases
C. Fanello, M. Onyamboko, S. J. Lee, C. Woodrow, S. Setaphan, K. Chotivanich, P. Buffet, S. Jaureguiberry, K. Rockett, K. Stepniewska, N. P. J. Day, N. J. White, A. M. Dondorp
BMC INFECTIOUS DISEASES
(2017)
Review
Psychology, Educational
Louisa McNair, Ceri Woodrow, Dougal Hare
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
(2017)