Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

(2014) K. Mleczko-Sanecka et al.   BLOOD

A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

(2014) Guillem Casanovas et al.   PLoS Computational Biology

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes

(2013) Christina Ellervik et al.   DIABETES CARE

Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta-analysis of prospective evidence

(2013) Setor K. Kunutsor et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

(2013) Ângela C. Crespo et al.   NEUROBIOLOGY OF AGING

Iron Deficiency Anemia: A Common and Curable Disease

(2013) J. L. Miller   Cold Spring Harbor Perspectives in Medicine

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

(2013) Irene Pichler et al.   PLOS MEDICINE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Diurnal Rhythm rather than Dietary Iron Mediates Daily Hepcidin Variations

(2012) C. C. M. Schaap et al.   CLINICAL CHEMISTRY

Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins

(2012) Junjing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seventy-five genetic loci influencing the human red blood cell

(2012) Pim van der Harst et al.   NATURE

Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis

(2012) Umbreen Ahmed   WORLD JOURNAL OF GASTROENTEROLOGY

Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis

(2011) Omar Saeed et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Total Mortality by Transferrin Saturation Levels: Two General Population Studies and a Metaanalysis

(2011) C. Ellervik et al.   CLINICAL CHEMISTRY

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

(2011) Irene Pichler et al.   HUMAN MOLECULAR GENETICS

Mutant HFE H63D Protein Is Associated with Prolonged Endoplasmic Reticulum Stress and Increased Neuronal Vulnerability

(2011) Yiting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HFE Gene Variants Affect Iron in the Brain

(2011) Wint Nandar et al.   JOURNAL OF NUTRITION

Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic Plaques

(2011) Aloke V. Finn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Mass Spectrometry Analysis of Hepcidin Peptides in Experimental Mouse Models

(2011) Harold Tjalsma et al.   PLoS One

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

(2011) Rozenn N. Lemaitre et al.   PLoS Genetics

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload

(2010) Bobby J. Cherayil   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

(2010) Dawn M. Waterworth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

(2010) H. Forejtnikova et al.   BLOOD

Circadian Rhythm of Transferrin Receptor 1 Gene Expression Controlled by c-Myc in Colon Cancer-Bearing Mice

(2010) F. Okazaki et al.   CANCER RESEARCH

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Influences of sleep and the circadian rhythm on iron-status indices

(2010) Peter Ridefelt et al.   CLINICAL BIOCHEMISTRY

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

Iron Overload in Thalassemia and Related Conditions: Therapeutic Goals and Assessment of Response to Chelation Therapies

(2010) John B. Porter et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes

(2010) Lu Qi et al.   HUMAN MOLECULAR GENETICS

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in lipid desaturases and its impact on the development of human disease

(2010) Diana M Merino et al.   Lipids in Health and Disease

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies

(2009) Priya Duggal et al.   BMC GENOMICS

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

(2009) Santhi K Ganesh et al.   NATURE GENETICS

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

(2009) Beben Benyamin et al.   NATURE GENETICS

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

(2009) Nicole Soranzo et al.   NATURE GENETICS

Genetic mechanisms and modifying factors in hereditary hemochromatosis

(2009) Günter Weiss   Nature Reviews Gastroenterology & Hepatology

Heritability and Demographic Analyses in the Large Isolated Population of Val Borbera Suggest Advantages in Mapping Complex Traits Genes

(2009) Michela Traglia et al.   PLoS One

Diurnal cycle influences peripheral and brain iron levels in mice

(2008) Erica L. Unger et al.   JOURNAL OF APPLIED PHYSIOLOGY

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Iron-Overload–Related Disease inHFEHereditary Hemochromatosis

(2008) Katrina J. Allen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY