Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS

High on-aspirin platelet reactivity predicts cardiac death in acute coronary syndrome patients undergoing PCI

(2016) Anna Maria Gori et al.   European Journal of Internal Medicine

COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance

(2016) R. Poorani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aspirin may improve outcome in sepsis by augmentation of the inflammatory response

(2016) H. D. Kiers et al.   INTENSIVE CARE MEDICINE

New Definitions for Sepsis and Septic Shock

(2016) Edward Abraham   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

(2016) Manu Shankar-Hari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients

(2016) Thomas C. Hall et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery

(2015) Michael Mazzeffi et al.   ANESTHESIA AND ANALGESIA

Causes and consequences of coagulation activation in sepsis: an evolutionary medicine perspective

(2015) Maiara Marx Luz Fiusa et al.   BMC Medicine

Prehospital Aspirin Use Is Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Patients

(2015) Wei Chen et al.   CRITICAL CARE MEDICINE

Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients

(2015) Sarah K. Orr et al.   CRITICAL CARE MEDICINE

Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study

(2015) Min-Juei Tsai et al.   INTENSIVE CARE MEDICINE

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis

(2015) B. Wu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

(2015) Luciano Ribeiro Filgueiras et al.   Science Signaling

Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

(2015) Luciano Ribeiro Filgueiras et al.   Science Signaling

State of the art papers HLA-DR expression, cytokines and bioactive lipids in sepsis

(2014) Undurti Das   Archives of Medical Science

A Randomized Controlled Trial Investigating the Effects of Parenteral Fish Oil on Survival Outcomes in Critically Ill Patients With Sepsis

(2014) Thomas C. Hall et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response

(2013) F. Chen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Dual role of lipoxin A4 in pneumosepsis pathogenesis

(2013) Regina Sordi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dietary fish oil reduces systemic inflammation and ameliorates sepsis-induced liver injury by up-regulating the peroxisome proliferator-activated receptor gamma-mediated pathway in septic mice

(2013) Cheng-Chung Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers

(2013) Jane F. Ferguson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of aspirin resistance

(2013) Christopher N. Floyd et al.   PHARMACOLOGY & THERAPEUTICS

Lipoxin A4 promotes more complete inflammation resolution in sepsis compared to stable lipoxin A4 analog

(2013) B. Wu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

(2012) Jochen Grommes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis

(2012) Damon P. Eisen et al.   CRITICAL CARE MEDICINE

Sepsis-associated changes of the arachidonic acid metabolism and their diagnostic potential in septic patients*

(2012) Mathias Bruegel et al.   CRITICAL CARE MEDICINE

Is sepsis a pro-resolution deficiency disorder?

(2012) Undurti N. Das   MEDICAL HYPOTHESES

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Effect of an enteral diet enriched with eicosapentaenoic acid, gamma-linolenic acid and anti-oxidants on the outcome of mechanically ventilated, critically ill, septic patients

(2011) Teodoro Grau-Carmona et al.   CLINICAL NUTRITION

Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome*

(2011) Hollis R. OʼNeal et al.   CRITICAL CARE MEDICINE

Association of prehospitalization aspirin therapy and acute lung injury: Results of a multicenter international observational study of at-risk patients*

(2011) Daryl J. Kor et al.   CRITICAL CARE MEDICINE

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

(2011) Todd W. Rice   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of the Effects of Different Intravenous Fat Emulsions in Patients With Systemic Inflammatory Response Syndrome and Sepsis

(2011) Hulya Sungurtekin et al.   NUTRITION IN CLINICAL PRACTICE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

(2011) Jean Walker et al.   SHOCK

Fish Oil in Critical Illness: Mechanisms and Clinical Applications

(2010) Renee D. Stapleton et al.   CRITICAL CARE CLINICS

Platelets as initiators and mediators of inflammation at the vessel wall

(2010) Guanfang Shi et al.   THROMBOSIS RESEARCH

Platelets as Central Mediators of Systemic Inflammatory Responses

(2010) Tammy L. Smith et al.   THROMBOSIS RESEARCH

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antiplatelet drugs and outcome in mixed admissions to an intensive care unit*

(2009) Johannes Winning et al.   CRITICAL CARE MEDICINE

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Amicus or Adversary

(2008) Fernando A. Bozza et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti-Inflammatory and Proresolving Lipid Mediators

(2008) Charles N. Serhan et al.   Annual Review of Pathology-Mechanisms of Disease