Article
Geochemistry & Geophysics
Wai Yeung Yan
Summary: Data artifacts are common in airborne lidar point clouds and their derivatives, degrading visual quality and compromising data-driven analyses. This article provides an overview of these artifacts and surveys existing solutions. From an end-user perspective, it aims to facilitate rapid issue diagnosis and efficient referrals to specialized resources during data collection and processing stages. The article also promotes collaboration between the scientific community, software developers, and system manufacturers for a comprehensive airborne lidar point cloud processing bundle.
IEEE GEOSCIENCE AND REMOTE SENSING MAGAZINE
(2023)
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Management
Sabrina Schneider, Olga Kokshagina
Summary: There has been a significant increase in discussions about the impact of digital technologies on business and society. This paper aims to highlight practical and research perspectives on business and management in the digital era by combining insights from senior managers and literature reviews. Challenges faced by firms in the early stages of digital transformation are identified, along with managerial guidance from numerous publications. The analysis points to emerging solutions for key challenges, while also highlighting remaining obstacles and new themes requiring attention for future practice-oriented research on digital transformation.
CREATIVITY AND INNOVATION MANAGEMENT
(2021)
Review
Oncology
Luani Rezende Godoy, Julio Cesar Possati-Resende, Yasmin Medeiros Guimaraes, Priscila Grecca Pedrao, Ricardo dos Reis, Adhemar Longatto-Filho
Summary: This review explores the initiatives conducted in Latin American countries to implement or evaluate the implementation of HPV testing, finding that HPV implementation is feasible and promising for reducing cervical cancer morbidity and mortality. However, the cost saving lives and reducing suffering must be pragmatically evaluated by Latin American governments, making improving outcomes a mandatory priority for addressing an organized system of cervical cancer screening.
Article
Biology
Ihor Krasivskyi, Clara Grossmann, Marit Dechow, Ilija Djordjevic, Borko Ivanov, Stephen Gerfer, Walid Bennour, Elmar Kuhn, Anton Sabashnikov, Navid Mader, Kaveh Eghbalzadeh, Thorsten Wahlers
Summary: Through the analysis of our mobile ECMO program patients from the past seven years, we found that despite extensive experience, the ECMO team learning curve does not significantly benefit patients' outcomes. There were significant differences in complications after ECMO implantation between the survival and non-survival groups, with a higher incidence of thromboembolic events, hepatic failure, renal failure, dialysis, and systemic inflammatory response syndrome in the non-survival group. This highlights the need for greater focus on patient selection and ECMO indication.
Review
Biochemistry & Molecular Biology
Bilal Abdulmawjood, Beatriz Costa, Catarina Roma-Rodrigues, Pedro V. Baptista, Alexandra R. Fernandes
Summary: Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease with the Philadelphia chromosome (Ph) as its molecular hallmark, leading to reactive oxygen species accumulation and genetic instability. Genetic abnormalities and altered genes related to cell apoptosis, proliferation, cell adhesion, TGF-beta, and TNF-alpha pathways have been correlated with CML in the blast phase. Dysregulation of critical miRNAs like miRNA-451 and miRNA-21 is also associated with pathogenesis and disease progression in CML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Lok Lam Ngai, Angele Kelder, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Summary: Acute myeloid leukemia is a heterogeneous disease with poor survival, and many patient- and leukemia-specific characteristics have been shown to be valuable prognostic factors, with measurable residual disease (MRD) playing a crucial role in prognostic assessment. Multiparameter flow cytometry (MFC) based MRD measurement is currently the most commonly used method, with combinations of different techniques showing promising results in improving its prognostic value.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Caio Oliveira De Sa-Ferreira, Camila Helena Macedo da Costa, Joao Campos Wiltgen Guimaraes, Nathasha Souza Sampaio, Leticia de Moraes Lopes Silva, Larissa Paula de Mascarenhas, Nicollas Garcia Rodrigues, Talita Labonia dos Santos, Solange Campos, Esther Cytrynbaum Young
Summary: There is a clear correlation between COVID-19 and diabetic ketoacidosis (DKA). SARS-CoV-2 infection can precipitate hyperglycemia and ketoacidosis in both diabetic and nondiabetic patients, leading to severe outcomes. DKA in COVID-19 patients may increase risk and worsen outcomes, emphasizing the need for rapid interventions to minimize complications and spreading.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Cell Biology
Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knezevic, Cyprian Winogradow, Karolina Amaro, Ewa Jonczyk-Matysiak, Beata Weber-Dabrowska, Justyna Rekas, Andrzej Gorski
Summary: Combining phages with antibiotics can enhance bacterial clearance and reduce biofilm formation, demonstrating a synergistic effect. Some studies have also shown that antibiotics can induce the production of phages by bacteria. In clinical applications, simultaneous treatment with phages and antibiotics has been found to improve treatment outcomes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Igor V. Maev, Maria A. Livzan, Sergei I. Mozgovoi, Olga V. Gaus, Dmitry S. Bordin
Summary: GERD is a common digestive system disease that significantly affects patients' quality of life. It can lead to the development of Barrett's esophagus, which is associated with a high risk of esophageal adenocarcinoma. The frequency and duration of stomach contents reflux are important factors in the progression of the disease.
Article
Economics
Pedro Brinca, Joao Ricardo Costa Filho, Francesca Loria
Summary: This paper introduces a business cycle accounting (BCA) method for explaining economic fluctuations and provides a software tool to assist practitioners in conducting BCA exercises. By studying the recessions in 1973 and 1990 in the United States and reflecting on the criticisms of BCA, the paper demonstrates the effectiveness of this method. In economic cycle research, the BCA method accurately identifies relevant theories and draws conclusions.
JOURNAL OF ECONOMIC SURVEYS
(2023)
Review
Virology
Eliana De Luca, Giuseppe Andrea Sautto, Paolo Emidio Crisi, Alessio Lorusso
Summary: Felino morbillivirus (FeMV) was first identified in stray cats in Hong Kong in 2012 and has since been found in domestic cats worldwide. While a potential link between FeMV infection and tubulointerstitial nephritis (TIN) has been suggested, it remains unproven, leading to controversy. Research on FeMV has primarily focused on its epidemiology, role in chronic kidney disease, and tropism, but its pathogenicity is still unclear due to its unique characteristics and lack of a rapid isolation cell culture system.
Review
Nutrition & Dietetics
Alessandra Berry, Barbara Collacchi, Roberta Masella, Rosaria Vari, Francesca Cirulli
Summary: The global increase in lifespan is expected to lead to a rise in cognitive impairment, prompting a shift towards natural products like curcumin for potential treatment. Despite promising preclinical studies, challenges such as low bioavailability and rapid metabolism have hindered curcumin's clinical efficacy, prompting the need for new strategies to improve its use.
Review
Biochemistry & Molecular Biology
Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Aleksandra Ruzicic, Nebojsa Jasnic, Sinisa Djurasevic, Jelena Djordjevic, Predrag Vujovic
Summary: Insulin, originally thought to be only produced by the pancreas, has also been found to be synthesized in various brain regions. It plays important roles in neuroprotection, control of growth hormone secretion, regulation of appetite, and neuronal glucose uptake. The impairment of brain-derived insulin signaling is associated with memory decline in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Alice Sabatino, Lilian Cuppari, Peter Stenvinkel, Bengt Lindholm, Carla Maria Avesani
Summary: Sarcopenia, initially defined as muscle loss in elderly by Irwin Rosenberg in 1988, has now evolved to encompass not only muscle mass loss but also strength and physical performance decline in consensus papers. In CKD, sarcopenia is prevalent not just due to aging, but also accelerated protein breakdown from the disease and dialysis, associated with worse clinical outcomes.
JOURNAL OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandra Jose, Sreevidya S. Devi, Anjana Sajeev, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Abdulrahman Alshammari, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Farnesoid X receptor (FXR) regulates genes involved in lipid, carbohydrate, and inflammatory processes. It is a possible tumor suppressor and its down-regulation is associated with various diseases. FXR agonism has been shown to improve survival in certain cancers, and the development of novel agonists could have therapeutic potential. Computer-aided drug design can be used to identify potential candidates, and alvimopan and montelukast were found to have strong binding affinity with FXR in this study.
BIOSCIENCE REPORTS
(2023)
Review
Oncology
Ramya Venkat, Elika Verma, Uzini Devi Daimary, Aviral Kumar, Sosmitha Girisa, Uma Dutta, Kwang Seok Ahn, Ajaikumar B. Kunnumakkara
Summary: This article reviews the molecular targets, biological activities, and beneficial effects of resveratrol (RSV) as an anti-inflammatory compound for the prevention and treatment of inflammation-mediated chronic disorders. RSV has been found to have anti-aging, anti-cancer, anti-inflammatory, antioxidant, and cardio protective properties. However, its rapid elimination through the metabolic system and low bio-availability is a significant issue that requires further study.
CANCER INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Bhagyashree Deka, Pratap Chandra, Priyanka Yadav, Ayushi Rehman, Sweta Kumari, Ajaikumar B. Kunnumakkara, Kusum Kumari Singh
Summary: This study reveals that RNPS1 is highly expressed in cervical carcinoma and promotes cell proliferation, migration, and invasion. Furthermore, RNPS1 regulates alternative splicing of key genes and promotes the formation of tumor-associated splice variants. These findings suggest that RNPS1 plays a significant role in the development of cervical cancer.
Review
Oncology
Mangala Hegde, Sosmitha Girisa, Nikunj Naliyadhara, Aviral Kumar, Mohammed S. Alqahtani, Mohamed Abbas, Chakrabhavi Dhananjaya Mohan, Sudha Warrier, Kam Man Hui, Kanchugarakoppal S. Rangappa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: This review focuses on the therapeutic effects of natural compounds targeting nuclear receptors (NRs) in cancer treatment, highlighting their advantages and limitations. The study emphasizes the importance of NRs in gene expression regulation and the potential of natural compounds as oncology drugs.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Food Science & Technology
Nikunj Naliyadhara, Aviral Kumar, Shailendra Kumar Gangwar, Thulsidharan Nair Devanarayanan, Mangala Hegde, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar Kunnumakara
Summary: The human gastrointestinal tract contains a diverse range of microbial species, which play a role in regulating gut barrier homeostasis, immune system stimulation, and neurological health benefits through the gut-brain axis. Dietary changes can significantly affect the gut microbial population, and positive changes can be made by changing dietary style. Dietary antioxidants, such as those found in food, have been found to have a positive impact on gut microbial populations, which can help alleviate gut microbial dysbiosis and contribute to the development of gut microbe-targeting therapeutics for various diseases. This review discusses the health benefits of major dietary antioxidant groups, and the interaction between gut microbiota and these antioxidants through pre-clinical and human dietary interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Oncology
Mangala Hegde, Nikunj Naliyadhara, Jyothsna Unnikrishnan, Mohammed S. Alqahtani, Mohamed Abbas, Sosmitha Girisa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Metastasis is the main cause of cancer-related deaths, and despite advancements in treatment methods, it remains difficult to treat. Nanotechnology has shown promising applications in the diagnosis and treatment of metastatic cancer, with nanoparticles demonstrating the ability to target specific cells within metastatic regions. This review summarizes the current state of nanotechnology in the field and discusses its potential in various imaging techniques and combination therapies.
Review
Cell Biology
Aviral Kumar, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Mangala Hegde, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a global health hazard causing 10 million deaths in 2020, and although different treatment approaches have improved overall survival, advanced-stage treatment still has poor outcomes. Autophagy, a catabolic process, plays a role in cancer by maintaining cellular homeostasis and has both tumor-promoting and suppressive effects. Recent research has identified long non-coding RNAs (lncRNAs) as regulators of autophagy and their modulation of various cancer hallmarks. This review discusses the mechanistic role of lncRNAs in modulating autophagy and related proteins in different cancers.
Review
Chemistry, Medicinal
Ajaikumar B. Kunnumakkara, Mangala Hegde, Dey Parama, Sosmitha Girisa, Aviral Kumar, Uzini Devi Daimary, Prachi Garodia, Sarat Chandra Yenisetti, Oommen V. Oommen, Bharat B. Aggarwal
Summary: Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Review
Oncology
Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Busselberg, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Despite medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy can lead to side effects and drug resistance, highlighting the need for natural compounds that can sensitize cancer cells to overcome resistance. Resveratrol, a natural polyphenolic compound, has been shown to enhance the effectiveness of chemotherapy by modulating multiple pathways in CRC cells.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: A study found that Calebin A (CA), a compound derived from turmeric, inhibits colorectal cancer (CRC) cell migration by modulating the NF-kappa B pathway through the inhibition of HIF-1 alpha. CA suppressed the proliferation and migration of CRC cells, reduced the expression of metastatic factors, and induced apoptosis through inhibition of HIF-1 alpha. This research has important implications for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Prachi Garodia, Mangala Hegde, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal
Summary: Curcumin has pleiotropic immunomodulatory functions and neuroprotective properties, and can suppress neuroinflammation by modulating diverse signaling pathways.
INTEGRATIVE MEDICINE RESEARCH
(2023)