Article
Biology
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Recent research has found that the steroid hormone 17 beta-estradiol (E-2) is produced in the brain by both neurons and astrocytes. A new inducible knockout mouse model was created to specifically deplete the E-2 in astrocytes of adult mice, providing a better research model for studying brain-derived E-2 and its functions. The characterization of this mouse model confirmed the specific depletion of aromatase and E-2 in astrocytes, and revealed the neuroprotective role of astrocyte-derived E-2 in cerebral ischemia.
Article
Environmental Sciences
Nguyen Minh Tue, Hidenori Matsukami, Le Huu Tuyen, Go Suzuki, Pham Hung Viet, Agus Sudaryanto, Annamalai Subramanian, Shinsuke Tanabe, Tatsuya Kunisue
Summary: This study evaluated the receptor agonist activities of estrogen, androgen, and glucocorticoid in river water samples from Chennai and Bangalore (India), Jakarta (Indonesia), and Hanoi (Vietnam) using CALUX assays. The results showed that the major contributors to the agonist activities were estrogens and androgens, with the samples from India having higher activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Maria da Conceicao Barros-Oliveira, Danylo Rafhael Costa-Silva, Alesse Ribeiro dos Santos, Renato Oliveira Pereira, Jose Maria Soares-Junior, Benedito Borges da Silva
Summary: This systematic review investigates the influence of CYP19A1 gene expression levels on women with breast cancer. The findings suggest that increased or decreased levels of CYP19A1 gene expression may be associated with pathological clinical factors of disease, MFS, OS, DFS, WATT, markers of metabolic function, concentrations of E1, FSH, and the use of multiple exons 1 of the CYP19A1 gene in breast cancer.
Review
Nutrition & Dietetics
Amit Zamir, Tavor Ben-Zeev, Jay R. Hoffman
Summary: This review focuses on the impact of manipulating energy and nutrient intake on circulating concentrations of testosterone and the potential mechanisms governing these changes. The importance of understanding how changes in macronutrient and micronutrient intake can influence the androgen response is emphasized.
Review
Chemistry, Inorganic & Nuclear
Vidak Raicevic, Niko Radulovic, Marija Sakac
Summary: The medicinal chemistry of ferrocene is a rapidly growing field, with research focusing on ferrocene-steroid conjugates as targeted tools for hormone-dependent cancer cells. Attention was specifically paid to the antitumor potential testing of these conjugates.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Giada Ostinelli, Sofia Laforest, Scott G. Denham, Marie-Frederique Gauthier, Virginie Drolet-Labelle, Emma Scott, Frederic-Simon Hould, Simon Marceau, Natalie Z. M. Homer, Catherine Begin, Ruth Andrew, Andre Tchernof
Summary: The study found that increased androgen catabolism or aromatization in women is associated with visceral adiposity and adipose tissue dysfunction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lise Barnard, Lina Schiffer, Renate Louw du-Toit, Jennifer A. Tamblyn, Shiuan Chen, Donita Africander, Wiebke Arlt, Paul A. Foster, Karl-Heinz Storbeck
Summary: Recent research has shown that 11-ketotestosterone, derived from the 11-oxygenated androgen biosynthesis pathway, contributes significantly to the active androgen pool in women. Despite the ability of human aromatase to generate 11-oxygenated estrogens from 11-oxygenated androgens, these estrogens were not detectable in circulation in individuals with high aromatase and 11-oxygenated androgen levels. This suggests that in vivo, 11-oxygenated androgens primarily function as androgens.
Article
Environmental Sciences
Tianyu Zhao, Kai Triebner, Iana Markevych, Marie Standl, Hicran Altug, Kees de Hoogh, Tamara Schikowski, Dietrich Berdel, Sibylle Koletzko, Carl-Peter Bauer, Andrea von Berg, Dennis Nowak, Joachim Heinrich
Summary: The study found no significant associations between long-term exposure to air pollutants and pubertal development based on sex hormone concentrations among 10-year-old children. More longitudinal studies are needed to further assess this association due to the limited number of current studies on this topic.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Annalisa Giandalia, Alfio Edoardo Giuffrida, Guido Gembillo, Domenico Cucinotta, Giovanni Squadrito, Domenico Santoro, Giuseppina T. Russo
Summary: Gender differences have been found in the incidence, phenotypes, and clinical manifestations of diabetic kidney disease (DKD), with hormonal factors, especially estrogen loss, playing a significant role in explaining these differences. Additional research on the impact of sex chromosomes and gene-sex interactions with susceptibility genes for DKD is ongoing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Matthew D. Taves, Jonathan D. Ashwell
Summary: Sex steroid hormones have significant effects on the thymus, causing thymic atrophy. Thymic epithelial cells (TEC), which are highly responsive to sex steroids, play a crucial role. Endogenous steroids have remarkable programming effects on the synthesis of T cell receptor (TCR) repertoire through TEC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ilaria Cellai, Vincenza Di Stasi, Paolo Comeglio, Elisa Maseroli, Tommaso Todisco, Chiara Corno, Sandra Filippi, Sarah Cipriani, Flavia Sorbi, Massimiliano Fambrini, Felice Petraglia, Irene Scavello, Giulia Rastrelli, Gabriele Acciai, Fabio Villanelli, Giovanna Danza, Erica Sarchielli, Giulia Guarnieri, Annamaria Morelli, Mario Maggi, Linda Vignozzi
Summary: This study confirmed that the human vagina is an androgen-target organ with the ability to synthesize androgens, thus providing support for the use of androgens for local symptoms of genitourinary syndrome in menopause.
Article
Multidisciplinary Sciences
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Summary: This study examined the role of dopamine D-5 receptors in impulse control and found that they are not necessary for impulse control. The results highlight the importance of time series analysis and detailed analysis of the learning process in understanding the behavioral functions of D-5 receptors.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Wen-Yu Chen, Yan-Peng Fu, Wen Zhong, Min Zhou
Summary: Our study found that E-DII was positively associated with androgens and estrogens in postmenopausal women, with some indicators showing non-linear associations, particularly among women who experienced natural menopause. Further research is needed to explore the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Yanhong Zhang, Nina Yin, Anbang Sun, Qifang Wu, Wenzhu Hu, Xin Hou, Xixi Zeng, Min Zhu, Yanhong Liao
Summary: Kidney fibrosis plays a significant role in chronic kidney disease, and EMT is an important molecular mechanism contributing to fibrosis. The study suggests that TRPC6 knockout may ameliorate kidney fibrosis by inhibiting EMT and down-regulating the AKT-mTOR and ERK1/2 pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhuan Song, Ning Liu, Yu He, Jingqing Chen, Jun Li, Fengchao Wang, Zhenlong Wu
Summary: Deletion of ICAT attenuates inflammation and fibrosis in obese mice, but has negligible effect on lipid metabolism.
Article
Transplantation
Iain Bressendorff, Ditte Hansen, Andreas Pasch, Stephen G. Holt, Morten Schou, Lisbet Brandi, Edward R. Smith
Summary: Increasing dialysate Mg was associated with reduced CPP load and systemic inflammation, as well as divergent changes in markers of bone formation and resorption.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Edward R. Smith
Editorial Material
Urology & Nephrology
Willi Jahnen-Dechent, Edward R. Smith
KIDNEY INTERNATIONAL
(2020)
Article
Cell Biology
Bin Zheng, Yuki Aoi, Avani P. Shah, Marta Iwanaszko, Siddhartha Das, Emily J. Rendleman, Didi Zha, Nabiha Khan, Edwin R. Smith, Ali Shilatifard
Summary: This study demonstrates the distinct and redundant biological functions among Pol II elongation factor paralogs through the use of orthogonal acute depletion/inhibition strategies, highlighting the roles of BRD4 and SEC families in Pol II release and pausing, as well as the stronger attenuation of the heat shock response through simultaneous depletion of AFF1 and AFF4.
GENES & DEVELOPMENT
(2021)
Editorial Material
Urology & Nephrology
Edward R. Smith, Timothy D. Hewitson
Summary: The renal signaling networks downstream of FGF23 remain unclear, but understanding them may provide an opportunity to regulate target genes independently of FGF23 in dysregulated mineral metabolism states. Ni et al. have identified HBEGF as a factor in the proximal tubules of mice that mimics the inductive effect of FGF23 on the vitamin D-catabolizing enzyme 24-hydroxylase through a common mitogen-activated protein kinase-dependent pathway. The implications of these findings for human disease are eagerly anticipated.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Mark K. Tiong, Rathika Krishnasamy, Edward R. Smith, Colin A. Hutchison, Elizabeth G. Ryan, Elaine M. Pascoe, Carmel M. Hawley, Tim D. Hewitson, Meg J. Jardine, Matthew A. Roberts, Yeoungjee Cho, Muh Geot Wong, Anne Heath, Craig L. Nelson, Shaundeep Sen, Peter F. Mount, Liza A. Vergara, Peta-Anne Paul-Brent, David W. Johnson, Nigel D. Toussaint
Summary: The use of MCO dialyzers over 24 weeks led to a sustained reduction in FGF23 levels, while other components of the uremic milieu were not significantly altered. Further studies are needed to determine if the reduction in FGF23 is associated with improved patient outcomes.
HEMODIALYSIS INTERNATIONAL
(2021)
Review
Physiology
Timothy D. Hewitson, Edward R. Smith
Summary: Chronic Kidney Disease (CKD) involves organ remodeling and fibrosis due to failed wound repair, with fibroblast activation and metabolic reprogramming playing key roles. Pro-fibrotic signals in response to injury induce metabolic changes in fibroblasts, with a shift towards glycolysis and enhanced glutamine metabolism. This metabolic remodeling may have broader implications for cellular function in CKD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Wasim Ahmed, Ali Abdul Kareem Al Obaidli, Princy Joseph, Edward R. Smith, Ayaz Ahmad Khan, Siddiq Anwar, Thangavelu Chandrasekar, Ayman Kamal Al Madani, Hormazdiar Dara Dastoor, Imran Zahid, Freddie Agbayani Costales, Yousef Abdul Rahim Boobes, Fatima Al Kindi, Salah Eldin Khalil Issa, Mohamed H. Hassan, Abraham George, Stephen Geoffrey Holt
Summary: This study investigated COVID-19 infection in hemodialysis patients, finding a 13% infection rate in the study period. Most infected patients were male, with an average age of 52, and family and community contacts were the main source of infection. Majority of patients had mild symptoms, but 13% required critical care.
Review
Urology & Nephrology
Chelsea Xu, Edward R. Smith, Mark K. Tiong, Irene Ruderman, Nigel D. Toussaint
Summary: Vascular calcification is associated with cardiovascular morbidity and mortality in people with CKD. Therapy involving magnesium or sodium thiosulfate appears most promising in attenuating the progression of vascular calcification, but the existing studies are small and of short duration. There is insufficient or conflicting data regarding other interventions, highlighting the need for more definitive trials in evaluating interventions targeting vascular calcification in people with CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
S. Bruell, K. M. Nicholls, T. D. Hewitson, A. S. Talbot, S. G. Holt, E. R. Smith, I Ruderman
Summary: Calciprotein particles (CPP) were found to be inversely correlated with total hip and femoral neck density in Fabry disease patients, but not with lumbar spine density. The levels of CPP-I and CPP-II were higher in male Fabry disease patients than female sufferers and their corresponding controls. Further research is needed to explore the relevance of sex-related differences and the potential use of CPP measurement in assessing bone disease in Fabry disease patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Mark K. Tiong, Stephen G. Holt, Martin L. Ford, Edward R. Smith
Summary: Elevated levels of calciprotein monomers (CPM) are associated with the progression of chronic kidney disease (CKD). This association may be mediated through increased phosphate load via fibroblast growth factor-23 (FGF23) and direct effects on the proximal tubule.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Letter
Urology & Nephrology
Edward R. Smith, Paul J. Champion de Crespigny, Fatima Vally, Tim D. Hewitson, Nigel D. Toussaint, Thomas J. Cade, Stephen G. Holt
KIDNEY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Lara W. Zeper, Edward R. Smith, Anique D. ter Braake, Paul T. Tinnemans, Jeroen H. F. de Baaij, Joost G. J. Hoenderop
Summary: Circulating calciprotein particles (CPP) have been identified as potential drivers of the calcification process in chronic kidney disease. This study compared CPP produced using different protocols in terms of particle morphology, composition, particle number, and in vitro calcification potency. The results showed that the composition of CPP and the method of quantification play a role in determining their calcification potency, and synthetic CPP are not comparable to endogenous CPP in terms of calcification propensity.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Mark K. Tiong, Edward R. Smith, Nigel D. Toussaint, Hasan F. Al-Khayyat, Stephen G. Holt
Summary: This study demonstrates that in patients with CID, treatment with infliximab can reduce the concentration of calciprotein particles (CPP) and shows a dynamic association with changes in bone turnover. Responders to treatment exhibit more favorable changes in bone formation and resorption markers compared to non-responders.
Meeting Abstract
Urology & Nephrology
M. K. Tiong, S. G. Holt, N. D. Toussaint, H. F. Al-Khayyat, E. R. Smith
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
