Article
Endocrinology & Metabolism
Yiting Wang, Jue Zhang, Junlin Zhang, Yucheng Wu, Rui Zhang, Honghong Ren, Mark E. Cooper, Fang Liu
Summary: The study found that female patients with DKD had higher levels of certain indicators (such as blood pressure, cholesterol levels) compared to male patients, but there was no significant association observed between sex differences and ESKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Muluneh Fashe, MyeongJin Yi, Tatsuya Sueyoshi, Masahiko Negishi
Summary: In menopause, circulating estrogen levels decrease significantly and the liver represses the capability of inactivating and excreting estrogens. Women are more prone to developing type 2 diabetes and liver diseases during this period. Phosphorylated nuclear receptors play a role in increasing the expression of genes involved in estrogen inactivation and excretion, possibly serving as a defense mechanism against estrogen toxicity in the livers of women.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Ivonne Loeffler, Nadja Ziller
Summary: Differences between the sexes exist in many diseases, but it is not as clear in diabetic kidney disease (DKD) due to various factors such as duration of diabetes, glycemic control, and other risk factors. Sex-specific factors like puberty or menopause also play a role in microvascular complications for both males and females. This review aims to summarize the current knowledge on sex-related aspects in the development, progression, and treatment strategies of DKD, including findings from preclinical research.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Marek Saracyn, Bartlomiej Kisiel, Maria Franaszczyk, Dorota Brodowska-Kania, Wawrzyniec Zmudzki, Robert Malecki, Longin Niemczyk, Przemyslaw Dyrla, Grzegorz Kaminski, Rafal Ploski, Stanislaw Niemczyk
Summary: Our study suggests that SNPs associated with DKD may not be specific for DKD but may increase the risk for CKD of different etiology, particularly those affecting renal glomeruli.
WORLD JOURNAL OF DIABETES
(2021)
Article
Multidisciplinary Sciences
An-Sofie Vanherwegen, Patrick Lauwers, Astrid Lavens, Kris Doggen, Eveline Dirinck
Summary: This study aimed to describe the differences between sexes in patient characteristics, ulcer severity, and outcomes in individuals with a diabetic foot ulcer (DFU). Men presented with more severe DFU than women. Female sex was significantly associated with a higher probability of ulcer healing.
Article
Medicine, General & Internal
Liang Ma, Shaoting Wang, Hailing Zhao, Meijie Yu, Xiangling Deng, Yongwei Jiang, Yongtong Cao, Ping Li, Wenquan Niu
Summary: The study found a significant association between two polymorphisms in the ApoB gene and diabetic kidney disease (DKD) risk, as well as an increased risk of DKD associated with haplotype T-A-G-T. The ApoB gene may be a candidate gene for DKD in Chinese patients with type 2 diabetes mellitus.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Chatchai Kreepala, Pitirat Panpruang, Rapeeporn Yodprom, Teeraya Piyajarawong, Krittanont Wattanavaekin, Taechasit Danjittrong, Sadiporn Phuthomdee
Summary: FRMD3 gene polymorphisms may be used as an alternative test to differentiate diabetic nephropathy (DN) from nondiabetic renal disease (NDRD) in type 2 diabetes mellitus (DM) patients. The C allele, especially homozygous CC, was associated with NDRD pathology in patients with overt proteinuria.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Cardiac & Cardiovascular Systems
Leah Hernandez, Agne Laucyte-Cibulskiene, Liam J. Ward, Alexandra Kautzky-Willer, Maria-Trinidad Herrero, Colleen M. Norris, Valeria Raparelli, Louise Pilote, Peter Stenvinkel, Karolina Kublickiene
Summary: Cardio-pulmonary diseases have become a major health issue for both men and women. Gender and sex play important roles in disease diagnosis and treatment. Recent research has shown that females may have different pathophysiology for heart disease, and females have a higher prevalence of pulmonary disorders. However, the socio-cultural role of gender in interventions is still understudied. This review highlights the importance of gender dimension and its interrelation with chronic kidney disease in the cardio-pulmonary continuum.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Jihan Sleiman, Gervasio Soler Pujol, Erika Montanez, Veronica Roatta, Gustavo Laham
Summary: Sex and gender are often used interchangeably, but gender is a more fluid and dynamic concept that encompasses psychosocial and cultural aspects. Inequality in medicine, particularly gender inequality, has been overlooked for a long time and is now a pressing concern. This study investigates gender equality in patients with chronic kidney disease (CKD) and highlights disparities in access to different treatment modalities.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Maria Marques, Paula Lopez-Sanchez, Fernando Tornero, Pedro Gargantilla, Alba Maroto, Alberto Ortiz, Jose Portoles
Summary: This study aimed to compare the actual prevalence of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients using laboratory data with the presence of diagnostic terms in electronic medical records (EMRs). The results showed that the prevalence of DKD based on lab data was significantly higher than that reported in hospital EMRs. This suggests a potential underdiagnosis of DKD, particularly in patients with less severe disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Sara Sargazi, Behrouz Mollashahi, Saman Sargazi, Milad Heidari Nia, Ramin Saravani, Shekoufeh Mirinejad, Ali Alidadi
Summary: Variants of miR146a gene are associated with CKD risk, with rs2910164 C/G and rs57095329 A/G polymorphisms increasing the risk, while rs6864584 T/C variant decreasing the risk in non-diabetic patients. Further studies with larger sample sizes on different races are needed to confirm these results.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yanxiu Liu, Yan Chen, Qiwei Yang, Dihan Shen, Zhenwu Du, Guizhen Zhang
Summary: This study found that SLC34A1 rs6420094 is associated with a decreased risk of DKD in the Chinese Han population, and the SNP-SNP interaction between rs17319721 and rs6420094 is associated with a lower risk of DKD.
ACTA DIABETOLOGICA
(2023)
Article
Public, Environmental & Occupational Health
Cong Li, Honghua Yu, Zhuoting Zhu, Xianwen Shang, Yu Huang, Charumathi Sabanayagam, Xiaohong Yang, Lei Liu
Summary: This study aimed to explore the association between blood pressure and the risk of diabetic microvascular complications (DMCs). The results showed that participants with higher systolic blood pressure had a lower risk of DMCs, and hypertension defined by the 2017 ACC/AHA guidelines may not have a significant impact on the incidence of DMCs compared to the JNC 7 criteria.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Medicine, General & Internal
Sebastian Hoedlmoser, Teresa Gehrig, Marlies Antlanger, Amelie Kurnikowski, Michal Lewandowski, Simon Krenn, Jarcy Zee, Roberto Pecoits-Filho, Reinhard Kramar, Juan Jesus Carrero, Kitty J. Jager, Allison Tong, Friedrich K. Port, Martin Posch, Wolfgang C. Winkelmayer, Eva Schernhammer, Manfred Hecking, Robin Ristl
Summary: This study found evidence of sex disparities in wait-listing and kidney transplantation after dialysis initiation. Historically, men in the US and Austria had higher chances of being wait-listed for kidney transplantation, although these gaps decreased over time. Efforts should be continued to make kidney transplantation equally accessible for both sexes, especially for older women.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xinyu Wang, Han Wu, Guangyan Yang, Jiaqing Xiang, Lijiao Xiong, Li Zhao, Tingfeng Liao, Xinyue Zhao, Lin Kang, Shu Yang, Zhen Liang
Summary: REG1A and RUNX3 may serve as biomarkers for predicting the risk of developing DKD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Carmelo Tiberio Curro, Giulia Nicocia, Vanessa Ziccone, Antonio Ciacciarelli, Giuseppina Russo, Antonio Toscano, Carmen Terranova, Paolo Girlanda
Summary: This case report describes a 70-year-old female patient with diabetic chorea, who benefitted from pimozide treatment but later died of pancreatic cancer. The patient initially presented with symptoms of choreic movements and high blood sugar, and despite various treatments, only pimozide proved effective in managing her symptoms. The diagnosis of pancreatic cancer several months after the onset of chorea suggests a potential causal link between the two conditions.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Guido Gembillo, Luca Visconti, Alfio Edoardo Giuffrida, Vincenzo Labbozzetta, Luigi Peritore, Antonella Lipari, Vincenzo Calabrese, Giorgina Barbara Piccoli, Massimo Torreggiani, Rossella Siligato, Domenico Santoro
Summary: Zinc plays a potential role in kidney and body homeostasis in diabetic patients and those at a high risk of developing diabetic kidney disease by counteracting diabetes-related risk factors and reducing oxidative stress levels, which can slow down the progression of kidney disease.
Review
Biochemistry & Molecular Biology
Guido Gembillo, Vincenzo Labbozzetta, Alfio Edoardo Giuffrida, Luigi Peritore, Vincenzo Calabrese, Claudia Spinella, Maria Rita Stancanelli, Eugenia Spallino, Luca Visconti, Domenico Santoro
Summary: Copper is a crucial element for body homeostasis and its imbalances can lead to various diseases. Both copper deficiency and excessive exposure can cause harm to multiple organs. Particularly, the influence of copper on diabetes and its complications, such as Diabetic Kidney Disease, has been studied extensively.
Review
Health Care Sciences & Services
Guido Gembillo, Sebastiano Calimeri, Valeria Tranchida, Salvatore Silipigni, Davide Vella, Domenico Ferrara, Claudia Spinella, Domenico Santoro, Luca Visconti
Summary: Chronic kidney disease (CKD) affects over 10% of the global population or more than 800 million people. It poses a heavy burden on low- and middle-income countries and has become a leading cause of death worldwide. The interaction of lung and kidney in CKD leads to complex clinical scenarios, impacting fluid balance, acid-base balance, and vascular function.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Annalisa Giandalia, Giuseppina Tiziana Russo, Patrizia Ruggeri, Annalisa Giancaterini, Elisabetta Brun, Mariarosaria Cristofaro, Anna Bogazzi, Maria Chiara Rossi, Giuseppe Lucisano, Alberto Rocca, Valeria Manicardi, Paolo Di Bartolo, Graziano Di Cianni, Chiara Giuliani, Angela Napoli
Summary: This study investigated the prevalence of obesity and severe obesity, clinical correlates, and potential sex differences in a large cohort of T1D subjects in Italy. The results showed that obesity was similar between men and women, but severe obesity was more prevalent among women. Obesity was associated with a higher burden of cardiovascular disease risk factors and complications, and a lower quality of care, with no major sex differences.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Medicine, General & Internal
Clelia Asero, Annalisa Giandalia, Irene Cacciola, Carmela Morace, Giuseppe Lorello, Amalia Rita Caspanello, Angela Alibrandi, Giovanni Squadrito, Giuseppina T. Russo
Summary: This study aimed to evaluate the occurrence and severity of liver fibrosis in type 2 diabetes outpatients without a known history of liver disease, and to identify predictive factors. The results showed that obesity, high triglycerides, worse glycemic control, and high creatinine levels were independent predictors of liver fibrosis in type 2 diabetes patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Elisa Longhitano, Paola Muscolino, Claudia Lo Re, Serena Ausilia Ferrara, Valeria Cernaro, Guido Gembillo, Dalila Tessitore, Desiree Speranza, Francesco Figura, Mariacarmela Santarpia, Nicola Silvestris, Domenico Santoro, Tindara Franchina
Summary: Immune-oncology has become a new therapeutic weapon in the past decade, revolutionizing the natural history of many cancers. Immune checkpoint inhibitors have changed outcomes for many patients, but can also cause inflammatory side-effects known as immune-related adverse events (irAEs). Renal toxicity from immune checkpoint inhibitors is rare, but early diagnosis and treatment are crucial to avoid toxicities and hospitalizations. Enhancing immune responses is a new challenge in anticancer therapies, and immune-related adverse events are common. This review provides a practical approach to the multidisciplinary management of cancer patients with renal toxicity during treatment with immune checkpoint inhibitors.
Review
Health Care Sciences & Services
Anna Licata, Giuseppina T. Russo, Annalisa Giandalia, Marcella Cammilleri, Clelia Asero, Irene Cacciola
Summary: In recent years, there has been increasing reports on gender differences in the epidemiology, pathophysiological mechanisms and clinical features of chronic liver diseases associated with type 2 diabetes (T2D). This sexual dimorphism is influenced by a complex interaction between sex- and gender-related factors. However, the impact of sex and gender on the management of T2D subjects with liver disease is still unclear. Therefore, it is important to consider sex-related differences in pharmacology in order to improve drug safety and optimize medical therapy in both men and women with T2D.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Nutrition & Dietetics
Valeria Cernaro, Michela Calderone, Guido Gembillo, Vincenzo Calabrese, Chiara Casuscelli, Claudia Lo Re, Elisa Longhitano, Domenico Santoro
Summary: Hyperphosphatemia is a common complication in advanced chronic kidney disease and can lead to cardiovascular morbidity and mortality. This review focuses on the management of phosphatemia in uremic patients receiving peritoneal dialysis. The control of serum phosphate in peritoneal dialysis patients is influenced by various factors such as patient transporter characteristics, peritoneal dialysis modalities, prescriptions, and diet. There is a need for more clinical trials specifically designed for peritoneal dialysis patients to evaluate the effects of multiple therapeutic approaches on serum phosphate control and clinical outcomes.
Editorial Material
Health Care Sciences & Services
Guido Gembillo, Rossella Siligato, Domenico Santoro
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Luigi Peritore, Vincenzo Labbozzetta, Veronica Maressa, Chiara Casuscelli, Giovanni Conti, Guido Gembillo, Domenico Santoro
Summary: Membranous nephropathy is a common autoimmune disease that affects the glomeruli and can lead to nephrotic syndrome and end-stage renal disease. The discovery of autoantibodies has improved our understanding of the disease and guided its diagnosis and treatment. Treatment options include supportive therapy and immunosuppressive drugs, but the choice of treatment should be based on individual patients.
MEDICINA-LITHUANIA
(2023)
Meeting Abstract
Transplantation
Guido Gembillo, Vincenzo Calabrese, Rossella Siligato, Elisa Longhitano, Daniela Metro, Domenico Santoro
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Guido Gembillo, Alfio Edoardo Giuffrida, Vincenzo Labbozzetta, Rossella Siligato, Eugenia Spallino, Giovanna Sposito, Guido Ferlazzo, Felicia Cuzzola, Antonella Lipari, Vincenzo Calabrese, Domenico Santoro
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Rossella Siligato, Guido Gembillo, Vincenzo Calabrese, Valeria Cernaro, Domenico Santoro
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
