Article
Immunology
Binzhen Chen, Jia Han, Shaoheng Chen, Rufeng Xie, Jie Yang, Tongming Zhou, Qi Zhang, Rong Xia
Summary: In this study, the regulatory pathway of miR-let-7b/TLR4/NF-kappa B in neutrophils was investigated. Overexpression of miR-let-7b down-regulated TLR4 expression and decreased proinflammatory factors while increasing anti-inflammatory factor in vitro. Treatment with miR-let-7b agomir in septic mice improved survival, reduced organ injuries, and inhibited neutrophil recruitment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chenghao Ren, Jie Jin, Wei Hu, Qi Chen, Jian Yang, Yaosen Wu, Yifei Zhou, Liaojun Sun, Weiyang Gao, Xiaolei Zhang, Naifeng Tian
Summary: The study showed that betulin can suppress inflammation induced by IL-1 beta and alleviate cartilage inflammation, acting through the activation of the AKT/Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Hardeep Singh Tuli, Katrin Sak, Dhruv Sanjay Gupta, Ginpreet Kaur, Diwakar Aggarwal, Nidarshana Chaturvedi Parashar, Renuka Choudhary, Mukerrem Betul Yerer, Jagjit Kaur, Manoj Kumar, Vivek Kumar Garg, Gautam Sethi
Summary: Betulin, derived from birch tree bark, has been shown to exert important anticancer activities by modulating diverse cellular pathways. Its participation in anti-inflammatory processes, especially by modulating NF-kappa B, prostaglandin/COX, and Nrf2-mediated cascades, has been recently understood. Betulin has the potential to enhance the antitumor action of traditional therapeutic modalities and may provide novel possibilities for targeting inflammation-related cancers when encapsulated into nanocarriers to overcome its low bioavailability.
Article
Food Science & Technology
Dan Li, Zhi Li, Caiyi Qiu, Bo Peng, Yan Zhang, Hongwen Sun, Shuo Wang
Summary: This study investigated the hepatotoxicity of 2-amino-3-methylimidazole[4,5-f] quinoline (IQ) in zebrafish models and found that IQ exposure led to significant increases in liver enzymes, oxidative stress, and inflammation levels, while decreasing antioxidant levels. The study also revealed the pathological changes in zebrafish liver tissue induced by IQ exposure and elucidated the underlying molecular mechanisms involved in IQ-induced liver damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Wei Dai, Ping Zheng, Deqiang Luo, Qian Xie, Fen Liu, Qiang Shao, Ning Zhao, Kejian Qian
Summary: This study aimed to identify ferroptosis-related genes in sepsis and provide potential therapeutic targets for translation. Through analysis of gene co-expression networks and differentially expressed genes, LPIN1 was identified as a reliable biomarker for patient survival in sepsis and was associated with immune and inflammation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Na Li, Guanjie Zhao, Mingzhu Xu
Summary: This study investigated the effects of Kluyveromyces marxianus on high-fat diet-induced kidney injury. The results showed that K. marxianus can have a beneficial effect on kidney injury by improving gut microbiota and inhibiting the activation of TLR4/NF-kappa B pathway.
CELLULAR MICROBIOLOGY
(2023)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Caiyun Yu, Dong Wang, Zaibin Yang, Tian Wang
Summary: TLR4/NF-kappa B is a key inflammatory signaling pathway involved in intestinal inflammation. Polyphenol phytochemicals exert pharmacological effects by targeting the TLR4/NF-kappa B signaling pathway, showing alleviative effects on intestinal inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zhenjia Li, Wenzhi Qu, Dongdong Zhang, Yue Sun, Dejing Shang
Summary: Excessive inflammatory responses contribute to high mortality in sepsis. Targeting macrophages and reducing proinflammatory cytokine release is a potential therapeutic strategy. Chensinin-1b, derived from Rana chensinensis skin secretion, effectively neutralizes LPS and alleviates LPS-induced inflammatory responses. It prolongs survival, reduces organ damage, and mitigates inflammatory responses in septic shock models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Health Care Sciences & Services
Huiping Wu, Ying Wang, Haiyan Fu, Lili Ji, Na Li, Dan Zhang, Longxiang Su, Zhansheng Hu
Summary: The study aimed to investigate the potential neuroprotective effects of Maresin1 (MaR1) on microglia-induced neuroinflammation in sepsis-induced cognitive impairment and explore its anti-inflammatory mechanism. The results showed that MaR1 significantly ameliorated cognitive dysfunction and inhibited neuroinflammation by suppressing the activations of NLRP3 and TLR4-NF-κB signal pathways.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Longhua Feng, Pengjiang Cheng, Zhengyun Feng, Xiaoyu Zhang
Summary: The overexpression of TMED2 in LUAD is negatively correlated with malignant survival and apoptosis. Knockdown of TMED2 inhibits LUAD development and increases the levels of inflammatory factors. In addition, TMED2 is associated with TME-associated immune cells, their target markers, and some mechanisms and pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin
Summary: Galgravin has anti-inflammatory effects, it can suppress NF-kappa B activation and reduce the expression of proinflammatory molecules, suggesting its potential application in inflammation diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ruoqi Li, Yuan Zhou, Shanshan Zhang, Jieying Li, Yingyi Zheng, Xiang Fan
Summary: This article discusses the role of inflammation in stroke and the therapeutic approach of modulating microglial phenotypes through the TLR4/NF-kappa B signaling pathway. It is found that dietary (poly)phenols have anti-inflammatory properties and provide protective effects on ischemic stroke.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dan Li, Ying-ying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiao-feng Zeng, Qian Zeng, Man Xu, Qi-zhu Tang
Summary: The study shows that lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms by inhibiting the TLR4-PI3K-Akt-NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Hao-Yu Che, Chang-Hai Zhou, Chen-Chen Lyu, Yu Meng, Yun-Tong He, Hao-Qi Wang, Hong-Yu Wu, Jia-Bao Zhang, Bao Yuan
Summary: Dairy farming is an important economic activity, and mastitis is a common disease in dairy cows. Allicin, a natural extract from garlic, has various beneficial properties including anti-inflammatory and antibacterial effects. This study found that allicin can reduce inflammation in the mammary epithelial cells of dairy cows, possibly through the TLR4/NF-kappa B signaling pathway. Allicin may be a promising alternative treatment for mastitis in cows.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.