STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)–STAT3 pathway

Inactivation of theCdkn2alocus cooperates withHMGA1to drive T-cell leukemogenesis

(2013) Francescopaolo Di Cello et al.   LEUKEMIA & LYMPHOMA

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia

(2013) Sujayita Roy et al.   LEUKEMIA & LYMPHOMA

Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth inHMGA1transgenic model of T-cell leukemia

(2013) Joelle Hillion et al.   LEUKEMIA & LYMPHOMA

Children's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia

(2012) Stephen P. Hunger et al.   PEDIATRIC BLOOD & CANCER

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

(2012) Amy Belton et al.   PLoS One

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

(2011) Andrew Schuldenfrei et al.   BMC GENOMICS

Flavopiridol inducesBCL-2expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia

(2011) Dwella M. Nelson et al.   LEUKEMIA & LYMPHOMA

The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

(2010) L. M.S. Resar   CANCER RESEARCH

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

(2008) J. Hillion et al.   CANCER RESEARCH