Alternative mRNA Splicing and Promising Therapies in Cancer

Delivery of antisense oligonucleotides for splice‐correction of androgen receptor pre‐mRNA in castration‐resistant prostate cancer models using cell‐penetrating peptides

(2022) Maria V. Luna Velez et al.   PROSTATE

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

(2022) Yoshihisa Kobayashi et al.   NATURE

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Transcript-Targeted Therapy Based on RNA Interference and Antisense Oligonucleotides: Current Applications and Novel Molecular Targets

(2022) Vincenza Barresi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

(2021) Patty Sachamitr et al.   Nature Communications

The International Human Genome Project

(2021) Ewan Birney   HUMAN MOLECULAR GENETICS

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

(2021) Ting Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

(2021) Wei Huang et al.   Journal of Hematology & Oncology

Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

(2021) David P. Steensma et al.   LEUKEMIA

Impact of alternative splicing on mechanisms of resistance to anticancer drugs

(2021) Maria Reviejo et al.   BIOCHEMICAL PHARMACOLOGY

ASO-based PKM splice-switching therapy inhibits hepatocellular carcinoma growth

(2021) Wai Kit Ma et al.   CANCER RESEARCH

Aberrant RNA splicing and therapeutic opportunities in cancers

(2021) Hirofumi Yamauchi et al.   CANCER SCIENCE

Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics

(2021) Qiu Peng et al.   MOLECULAR THERAPY

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

(2020) Xiangbing Meng et al.   Frontiers in Oncology

Writers, readers and erasers of RNA modifications in cancer

(2020) Rosaura Esteve-Puig et al.   CANCER LETTERS

Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

(2020) Dingxiao Zhang et al.   Nature Communications

The role of alternative splicing in cancer: From oncogenesis to drug resistance

(2020) Rocco Sciarrillo et al.   DRUG RESISTANCE UPDATES

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

(2019) Eric Wang et al.   CANCER CELL

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

(2019) Jia Yi Fong et al.   CANCER CELL

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

(2019) Megan Stevens et al.   Frontiers in Genetics

RNA Splicing by the Spliceosome

(2019) Max E. Wilkinson et al.   Annual Review of Biochemistry

Therapeutic approaches to treat human spliceosomal diseases

(2019) Anthony B DeNicola et al.   CURRENT OPINION IN BIOTECHNOLOGY

Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy

(2019) Xuesen Dong et al.   ONCOGENE

Final results of a phase 2, open-label study of indisulam, idarubicin, and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome

(2018) Rita Assi et al.   CANCER

Splicing dysregulation as a driver of breast cancer

(2018) Abigail Read et al.   ENDOCRINE-RELATED CANCER

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

(2018) Michael Seiler et al.   NATURE MEDICINE

Nuclear retention of mRNAs – quality control, gene regulation and human disease

(2018) Marius Wegener et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

hnRNP A1/A2 and Sam68 collaborate with SRSF10 to control the alternative splicing response to oxaliplatin-mediated DNA damage

(2018) Alexandre Cloutier et al.   Scientific Reports

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Systematic evaluation of isoform function in literature reports of alternative splicing

(2018) Shamsuddin A. Bhuiyan et al.   BMC GENOMICS

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Quantitative Activity Profile and Context Dependence of All Human 5′ Splice Sites

(2018) Mandy S. Wong et al.   MOLECULAR CELL

RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing

(2018) Takayuki Nojima et al.   MOLECULAR CELL

SR Proteins: Binders, Regulators, and Connectors of RNA

(2017) Sunjoo Jeong   MOLECULES AND CELLS

Pathogenic variants that alter protein code often disrupt splicing

(2017) Rachel Soemedi et al.   NATURE GENETICS

PRMT5 as a druggable target for glioblastoma therapy

(2017) Yeshavanth Kumar Banasavadi-Siddegowda et al.   NEURO-ONCOLOGY

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Alternative Splicing May Not Be the Key to Proteome Complexity

(2017) Michael L. Tress et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA splicing process analysis for identifying antisense oligonucleotide inhibitors with padlock probe-based isothermal amplification

(2017) Xiaojun Ren et al.   Chemical Science

The Functional Impact of Alternative Splicing in Cancer

(2017) Héctor Climente-González et al.   Cell Reports

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

(2017) Brenton R Paolella et al.   eLife

The BRCA1- 11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

(2016) Y. Wang et al.   CANCER RESEARCH

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

(2016) Sven Diederichs et al.   EMBO Molecular Medicine

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

(2016) Tassa Saldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Therapeutic targeting of splicing in cancer

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

Splicing-factor alterations in cancers

(2016) Olga Anczuków et al.   RNA

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms

(2016) Charlotte K. Brierley et al.   Current Hematologic Malignancy Reports

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

(2015) Eunhee Kim et al.   CANCER CELL

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

(2015) Cheryl M. Koh et al.   NATURE

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

(2014) A. S. Adler et al.   GENES & DEVELOPMENT

PRPF8 defects cause missplicing in myeloid malignancies

(2014) A Kurtovic-Kozaric et al.   LEUKEMIA

High antitumor activity of pladienolide B and its derivative in gastric cancer

(2013) Momoko Sato et al.   CANCER SCIENCE

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

(2011) Liying Fan et al.   ACS Chemical Biology

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts

(2011) Lu Chen et al.   HUMAN MOLECULAR GENETICS

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing

(2008) Kristine O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Splicing Factor RBM25 Modulates Bcl-x Pre-mRNA 5' Splice Site Selection

(2008) A. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS