Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia

(2014) Michael J. Burke et al.   AMERICAN JOURNAL OF HEMATOLOGY

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

(2014) S. Peirs et al.   BLOOD

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

(2014) Katharine Patrick et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential

(2014) Louise M. Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

(2013) M. P. McCormack et al.   BLOOD

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

(2013) Metin Karahoca et al.   Clinical Epigenetics

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

(2012) T. Bhatla et al.   BLOOD

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors

(2012) Fabian Zohren et al.   NATURE IMMUNOLOGY

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

(2011) L. E. Hogan et al.   BLOOD

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models

(2011) D J Morrison et al.   LEUKEMIA

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

(2009) Elaine Coustan-Smith et al.   LANCET ONCOLOGY

Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines

(2009) Stefan Nagel et al.   LEUKEMIA RESEARCH