MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

(2015) D. Moradi Manesh et al.   BLOOD

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells

(2015) Nagarathinam Selvaraj et al.   Cell Communication and Signaling

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

(2015) Kasper Jermiin Knudsen et al.   GENES & DEVELOPMENT

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

(2015) E. M. Lee et al.   HAEMATOLOGICA

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

(2015) E. M. Lee et al.   HAEMATOLOGICA

Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts

(2014) S. Suryani et al.   CLINICAL CANCER RESEARCH

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias

(2014) M L Tursky et al.   LEUKEMIA

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

(2013) D. Beck et al.   BLOOD

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

(2013) L. Goldberg et al.   BLOOD

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

(2013) E. Diffner et al.   BLOOD

Transcriptional Regulation of CXCR4 in Prostate Cancer: Significance of TMPRSS2-ERG Fusions

(2013) R. Singareddy et al.   MOLECULAR CANCER RESEARCH

Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase

(2013) Hong Ma et al.   PLoS One

Integrative network analysis of signaling in human CD34+hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2enrichment combined with 2D LC-MS/MS and pathway mapping

(2013) Hongbo Guo et al.   PROTEOMICS

Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis

(2012) P. Vijayaraj et al.   DEVELOPMENT

Phosphorylation regulates human OCT4

(2012) J. Brumbaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

(2011) J. A. I. Thoms et al.   BLOOD

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

(2011) A. P. Ng et al.   BLOOD

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation

(2010) Mary L. Spengler et al.   CELL CYCLE

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients

(2010) S H Oram et al.   ONCOGENE

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Functional redundancy of Ets1 and Ets2

(2009) P. Oettgen   BLOOD

ERG Is a Megakaryocytic Oncogene

(2009) S. Salek-Ardakani et al.   CANCER RESEARCH

ERGExpression Is an Independent Prognostic Factor and Allows Refined Risk Stratification in Cytogenetically Normal Acute Myeloid Leukemia: A Comprehensive Analysis ofERG, MN1, andBAALCTranscript Levels Using Oligonucleotide Microarrays

(2009) Klaus H. Metzeler et al.   JOURNAL OF CLINICAL ONCOLOGY

Differentiation-Dependent Interactions between RUNX-1 and FLI-1 during Megakaryocyte Development

(2009) H. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin

(2008) G. M. Birdsey et al.   BLOOD

Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia

(2008) Arend Bohne et al.   LEUKEMIA RESEARCH

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

(2008) Stephen J Loughran et al.   NATURE IMMUNOLOGY