EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC and can be targeted by SYK inhibition

(2016) S Köhrer et al.   LEUKEMIA

KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study

(2016) Ronan T. Swords et al.   LEUKEMIA RESEARCH

Antibody-mediated delivery of therapeutics for cancer therapy

(2015) Sagun Parakh et al.   Expert Opinion on Drug Delivery

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

(2015) Zhengshan Chen et al.   NATURE

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia

(2015) Sara Charmsaz et al.   PLoS One

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

(2015) Fares Al-Ejeh et al.   Oncotarget

Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment

(2014) M. E. Vail et al.   CANCER RESEARCH

A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity

(2014) Nenad Tomasevic et al.   GROWTH FACTORS

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

(2013) Bryan W. Day et al.   CANCER CELL

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells

(2012) John M. Ashton et al.   Cell Stem Cell

Copy Number Variations of EphA3 Are Associated With Multiple Types of Hematologic Malignancies

(2012) Ming Guan et al.   Clinical Lymphoma Myeloma & Leukemia

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology