Review
Agriculture, Multidisciplinary
Xiaofang Jiang, Boyu Sun, Zheng Zhou
Summary: This review introduces the molecular mechanisms by which gut microbiota contributes to the development of diabetes mellitus (DM), and summarizes the preclinical studies of bioactive natural products that exert antidiabetic effects by modulating the gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Cristian-Ioan Craciun, Maria-Adriana Neag, Adrian Catinean, Andrei-Otto Mitre, Adriana Rusu, Cornelia Bala, Gabriela Roman, Anca-Dana Buzoianu, Dana-Maria Muntean, Anca-Elena Craciun
Summary: This review evaluates the pathogenetic association between microbiota and diabetes and explores new therapeutic agents that may modulate the microbiota. It provides new insights into the treatment of diabetes.
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Ting Zhang, Jin-ke Cheng, Yao-min Hu
Summary: Sarcopenia, a progressive loss of skeletal muscle mass and function with aging, has been shown to be closely related to gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential in ameliorating muscle loss.
AGEING RESEARCH REVIEWS
(2022)
Article
Nutrition & Dietetics
Zubaidah Hasain, Raja Affendi Raja Ali, Hajar Fauzan Ahmad, Ummul Fahri Abdul Rauf, Seok Fang Oon, Norfilza Mohd Mokhtar
Summary: Multi-strain probiotics are beneficial for improving metabolic and inflammatory outcomes in post-GDM women by modulating gut dysbiosis. This study emphasizes the necessity for a comprehensive strategy for postpartum treatment that includes probiotics to protect post-GDM women from developing glucose intolerance.
Article
Agriculture, Multidisciplinary
Yuxiang Gu, Haoran Chen, Xing Li, Dan Li, Yue Sun, Lin Yang, Ying Ma, Eric Chun Yong Chan
Summary: This study found that Lactobacillus paracasei IMC 502 can prevent and alleviate type 2 diabetes by mediating the gut microbiota-SCFA-hormone/inflammation pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Haodong Liu, Yan Xing, Yinbo Wang, Xinxiu Ren, Danyang Zhang, Jianying Dai, Zhilong Xiu, Shiqiang Yu, Yuesheng Dong
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can reduce the risk of developing type 2 diabetes mellitus (T2DM) by regulating gut microbiota, relieving inflammation, and improving insulin resistance.
Review
Biochemistry & Molecular Biology
Lixiang Zhai, Jiayan Wu, Yan Y. Lam, Hiu Yee Kwan, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: Type 2 diabetes is a metabolic disorder characterized by insulin resistance and impaired insulin secretion leading to high blood sugar levels. Disturbances in gut microbiota play a significant role in the development of insulin resistance in T2D. Research on gut microbial metabolites and probiotics-based therapeutic strategies show promise in alleviating insulin resistance in T2D by modulating gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Edward C. Deehan, Zhengxiao Zhang, Alessandra Riva, Anissa M. Armet, Maria Elisa Perez-Munoz, Nguyen K. Nguyen, Jacqueline A. Krysa, Benjamin Seethaler, Yuan-Yuan Zhao, Janis Cole, Fuyong Li, Bela Hausmann, Andreas Spittler, Julie-Anne Nazare, Nathalie M. Delzenne, Jonathan M. Curtis, Wendy Wismer, Spencer D. Proctor, Jeffrey A. Bakal, Stephan C. Bischoff, Dan Knights, Catherine J. Field, David Berry, Carla M. Prado, Jens Walter
Summary: This study demonstrates the efficacy of purified dietary fibers when used as supplements and suggests that the satiating effects of AX may be linked to bacterial taxa that ferment the fiber or utilize breakdown products.
Article
Multidisciplinary Sciences
Rugang Li, Min He, Qilin Yang, Zezhi Liang, Ying li, Ling Huang, Rong Wu, Jieping Huang
Summary: This study explores the association between baseline serum creatinine level and new-onset type 2 diabetes in the Chinese population. The findings reveal that low serum creatinine is independently associated with an increased risk of type 2 diabetes among Chinese adults, and this association is consistent across different subgroups.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White, Peng Ye, Hein M. Tun, Yankai Xia
Summary: This study revealed significant changes in the meconium microbiota of neonates born to mothers with gestational diabetes mellitus (GDM), with a reduction in alpha diversity and alterations in the abundance of Firmicutes and Proteobacteria. Metabolomic analysis showed changes in metabolic pathways such as taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis in GDM subjects. The findings highlight the impact of maternal factors on early-life metabolism.
Article
Nutrition & Dietetics
Napapan Kangwan, Wasana Pratchayasakul, Aphisek Kongkaew, Komsak Pintha, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that PSO and metformin can effectively improve gut dysbiosis, inflammation, and metabolic disturbance in HFD-fed rats, with metformin showing greater benefits.
Review
Nutrition & Dietetics
Lingling Huang, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The alterations of gut microbiota, including changes in F/B ratio, SCFA-producing bacteria, bacteria with probiotics properties, and gram-negative LPS-producing bacteria, play a vital role in the development of GDM. Some studies have shown the beneficial effects of gut microbiota modification as a treatment for GDM, but further research is needed to fully understand the specific microbiota associated with GDM development and potentially identify novel diagnostic markers for early stages of the disease.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Ruolin Gao, Xiangjing Meng, Yili Xue, Min Mao, Yaru Liu, Xuewen Tian, Bo Sui, Xun Li, Pengyi Zhang
Summary: This review article focuses on the interaction between bile acids and gut microbiota in improving type 2 diabetes mellitus (T2DM). The findings highlight the critical role of bile acids in glucose metabolism and suggest their potential as therapeutic targets for T2DM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Che-Sheng Pai, Cheng-Yuan Wang, Wei-Wen Hung, Wei-Chun Hung, Hui-Ju Tsai, Chen-Chia Chang, Shang-Jyh Hwang, Chia-Yen Dai, Wen-Yu Ho, Yi-Chun Tsai
Summary: This study revealed that in Asian T2D patients, the decreased abundance of fecal A. muciniphila exacerbated the severity of insulin resistance, especially in those with lean mass. The negative correlation between A. muciniphila and insulin resistance was found in T2D patients with high lean tissue, and this relationship was independent of obesity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)