Integrating copy number data of 64 iAMP21 BCP-ALL patients narrows the common region of amplification to 1.57 Mb

Genetic characterisation of childhood B‐other‐acute lymphoblastic leukaemia in UK patients by fluorescence in situ hybridisation and Multiplex Ligation‐dependent Probe Amplification

(2021) Claire J. Schwab et al.   BRITISH JOURNAL OF HAEMATOLOGY

The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development

(2020) Mafalda Loreti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia

(2020) Chih-Hsiang Yu et al.   Scientific Reports

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

(2019) Zhaohui Gu et al.   NATURE GENETICS

SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

(2019) Paul B. Sinclair et al.   LEUKEMIA

MLPA as a complementary tool for diagnosis of chromosome 21 aberrations in childhood BCP-ALL

(2019) Ewa Wrona et al.   JOURNAL OF APPLIED GENETICS

Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia

(2019) Ingegerd Ivanov Öfverholm et al.   LEUKEMIA & LYMPHOMA

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

(2018) Paul. B. Sinclair et al.   HAEMATOLOGICA

SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia

(2018) LB Baughn et al.   Cancer Genetics

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

(2018) Paul. B. Sinclair et al.   HAEMATOLOGICA

Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1 driven B-cell precursor acute lymphoblastic leukemia

(2018) Roel Polak et al.   HAEMATOLOGICA

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

(2018) Cody T. Mowery et al.   Cell Reports

Is intrachromosomal amplification of chromosome 21 (iAMP21) always intrachromosomal?

(2017) Karen D. Tsuchiya et al.   Cancer Genetics

The role of the RAS pathway in iAMP21-ALL

(2016) S L Ryan et al.   LEUKEMIA

Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia

(2016) Judith M. Boer et al.   Oncotarget

Cytogenetic Variation of B-Lymphoblastic Leukemia With Intrachromosomal Amplification of Chromosome 21 (iAMP21)

(2015) Ryan C. Johnson et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease

(2015) C. J. Harrison   BLOOD

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures

(2015) J. M. Boer et al.   HAEMATOLOGICA

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures

(2015) J. M. Boer et al.   HAEMATOLOGICA

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

(2014) Yilong Li et al.   NATURE

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

(2014) Andrew A Lane et al.   NATURE GENETICS

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL

(2013) A. van der Veer et al.   BLOOD

The Xenopus homologue of Down syndrome critical region protein 6 drives dorsoanterior gene expression and embryonic axis formation by antagonising polycomb group proteins

(2013) H.-Y. Li et al.   DEVELOPMENT

Risk-Directed Treatment Intensification Significantly Reduces the Risk of Relapse Among Children and Adolescents With Acute Lymphoblastic Leukemia and Intrachromosomal Amplification of Chromosome 21: A Comparison of the MRC ALL97/99 and UKALL2003 Trials

(2013) Anthony V. Moorman et al.   JOURNAL OF CLINICAL ONCOLOGY

Intrachromosomal Amplification of Chromosome 21 Is Associated With Inferior Outcomes in Children With Acute Lymphoblastic Leukemia Treated in Contemporary Standard-Risk Children's Oncology Group Studies: A Report From the Children's Oncology Group

(2013) Nyla A. Heerema et al.   JOURNAL OF CLINICAL ONCOLOGY

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

(2013) C J Harrison et al.   LEUKEMIA

RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm

(2012) A. Janesick et al.   DEVELOPMENT

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

(2011) V. Rand et al.   BLOOD

Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy

(2011) Paul B. Sinclair et al.   HUMAN MOLECULAR GENETICS

Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice

(2010) T. Okubo et al.   DEVELOPMENT

Smoothing waves in array CGH tumor profiles

(2009) Mark A. van de Wiel et al.   BIOINFORMATICS

CGHnormaliter: an iterative strategy to enhance normalization of array CGH data with imbalanced aberrations

(2009) Bart PP van Houte et al.   BMC GENOMICS

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

(2009) Monique L Den Boer et al.   LANCET ONCOLOGY

Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004

(2009) W A Kamps et al.   LEUKEMIA

Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97

(2009) G Escherich et al.   LEUKEMIA