Next-Generation Boron Drugs and Rational Translational Studies Driving the Revival of BNCT

Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy

(2022) Shiori Hirase et al.   MOLECULAR PHARMACEUTICS

Boron encapsulated in a liposome can be used for combinational neutron capture therapy

(2022) Jiyuan Li et al.   Nature Communications

Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma

(2022) Jiejian Chen et al.   JOURNAL OF NANOBIOTECHNOLOGY

CAR T cells in solid tumors: challenges and opportunities

(2021) Faroogh Marofi et al.   Stem Cell Research & Therapy

Boron Neutron Capture Therapy: A Review of Clinical Applications

(2021) Timothy D. Malouff et al.   Frontiers in Oncology

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

The Emergence and Evolution of Borophene

(2021) Meitong Ou et al.   Advanced Science

Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway

(2021) Julie Constanzo et al.   Frontiers in Immunology

Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy

(2021) Kamila Maliszewska-Olejniczak et al.   Frontiers in Oncology

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model

(2021) Verónica A. Trivillin et al.   BRITISH JOURNAL OF RADIOLOGY

Boron Neutron Capture Therapy (BNCT) for Cutaneous Malignant Melanoma Using 10B-p-Boronophenylalanine (BPA) with Special Reference to the Radiobiological Basis and Clinical Results

(2021) Hiroshi Fukuda   Cells

Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism

(2020) Takahiro Nomoto et al.   Science Advances

Carborane‐containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron Capture Therapy (BNCT)

(2020) Daniel P. Becker et al.   ChemMedChem

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy

(2020) Kazuki Kawai et al.   MOLECULAR PHARMACEUTICS

Antibody-Based Receptor Targeting Using an Fc-Binding Peptide-Dodecaborate Conjugate and Macropinocytosis Induction for Boron Neutron Capture Therapy

(2020) Ikuhiko Nakase et al.   ACS Omega

Boron neutron capture therapy: Current status and future perspectives

(2020) Mayya Alexandrovna Dymova et al.   Cancer Communications

HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

(2020) Hsin-Hung Chen et al.   NEURO-ONCOLOGY

Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

(2019) Lisa Sevenich   Frontiers in Oncology

Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy

(2019) Bernardo Rapoport et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Harnessing radiation to improve immunotherapy: better with particles?

(2019) Marco Durante et al.   BRITISH JOURNAL OF RADIOLOGY

Boron-Nanoparticle-Loaded Folic-Acid-Functionalized Liposomes to Achieve Optimum Boron Concentration for Boron Neutron Capture Therapy of Cancer

(2019) Ajay Singh et al.   Journal of Biomedical Nanotechnology

BNCT induced immunomodulatory effects contribute to mammary tumor inhibition

(2019) Aslam Ali Khan et al.   PLoS One

On-Demand Biodegradable Boron Nitride Nanoparticles for Treating Triple Negative Breast Cancer with Boron Neutron Capture Therapy

(2019) Liping Li et al.   ACS Nano

Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)

(2019) Chun-Yi Wu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

In vitro studies of DNA damage and repair mechanisms induced by BNCT in a poorly differentiated thyroid carcinoma cell line

(2018) C. Rodriguez et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution

(2018) Tatsuhiko Sato et al.   Scientific Reports

Low-dose radiation conditioning enables CAR T cells to mitigate antigen escape

(2018) Carl DeSelm et al.   MOLECULAR THERAPY

Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer

(2017) Verónica A. Trivillin et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

The Immunoregulatory Potential of Particle Radiation in Cancer Therapy

(2017) Daniel K. Ebner et al.   Frontiers in Immunology

Macrophage biology plays a central role during ionizing radiation-elicited tumor response

(2017) Qiuji Wu et al.   Biomedical Journal

Does Heavy Ion Therapy Work Through the Immune System?

(2016) Marco Durante et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

An analysis of the structure of the compound biological effectiveness factor

(2016) Koji Ono   JOURNAL OF RADIATION RESEARCH

Targeting glioma stem cells enhances anti-tumor effect of boron neutron capture therapy

(2016) Ting Sun et al.   Oncotarget

Nanostructured Boron Nitride With High Water Dispersibility For Boron Neutron Capture Therapy

(2016) Bikramjeet Singh et al.   Scientific Reports

Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland

(2015) H. Koivunoro et al.   APPLIED RADIATION AND ISOTOPES

Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT

(2015) Hiroyuki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

(2015) Printip Wongthai et al.   CANCER SCIENCE

Tetrakis( p -Carboranylthio-Tetrafluorophenyl)Chlorin (TPFC): Application for Photodynamic Therapy and Boron Neutron Capture Therapy

(2015) Ryo Hiramatsu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide

(2014) Hiroyuki Michiue et al.   BIOMATERIALS

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

Antitumor Immunity Induced after α Irradiation

(2014) Jean-Baptiste Gorin et al.   NEOPLASIA

The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy

(2014) Shin-ichiro Masunaga et al.   SpringerPlus

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes

(2013) P. J. Kueffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

(2012) Rolf F Barth et al.   Radiation Oncology

Cytokines in Radiobiological Responses: A Review

(2012) Dörthe Schaue et al.   RADIATION RESEARCH

Role of T lymphocytes in tumor response to radiotherapy

(2012) Sandra Demaria et al.   Frontiers in Oncology

Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy

(2011) Sadaaki Kimura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

“Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

(2011) Ana J Molinari et al.   RADIATION RESEARCH

Carborane confined nanoparticles for boron neutron capture therapy: Improved stability, blood circulation time and tumor accumulation

(2011) Shogo Sumitani et al.   REACTIVE & FUNCTIONAL POLYMERS

Convection enhanced delivery of carboranylporphyrins for neutron capture therapy of brain tumors

(2010) Shinji Kawabata et al.   JOURNAL OF NEURO-ONCOLOGY

Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter

(2009) F.Y. Hsu et al.   APPLIED RADIATION AND ISOTOPES

Boron neutron capture therapy at the crossroads: Challenges and opportunities

(2009) Rolf F. Barth   APPLIED RADIATION AND ISOTOPES

Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies

(2009) Itsuro Kato et al.   APPLIED RADIATION AND ISOTOPES