Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Microbiology
Ana Montalban-Arques, Egle Katkeviciute, Philipp Busenhart, Anna Bircher, Jakob Wirbel, Georg Zeller, Yasser Morsy, Lubor Borsig, Jesus F. Glaus Garzon, Anne Mueller, Isabelle C. Arnold, Mariela Artola-Boran, Michael Krauthammer, Anna Sintsova, Nicola Zamboni, Gabriel E. Leventhal, Laura Berchtold, Tomas de Wouters, Gerhard Rogler, Katharina Baebler, Marlene Schwarzfischer, Larissa Hering, Ivan Olivares-Rivas, Kirstin Atrott, Claudia Gottier, Silvia Lang, Onur Boyman, Ralph Fritsch, Markus G. Manz, Marianne R. Spalinger, Michael Scharl
Summary: Despite the overall success of T cell checkpoint inhibitors in cancer treatment, research has found that certain commensal species of gut microbiota associated with lower tumor burden and are significantly reduced in CRC patients. Oral application of specific Clostridiales strains can prevent and even treat CRC successfully in mouse models, outperforming anti-PD-1 therapy in some cases. This indicates the potential of gut bacteria as a novel stand-alone therapy against solid tumors.
CELL HOST & MICROBE
(2021)
Review
Pharmacology & Pharmacy
Ting Jiang, Xisha Chen, Xingcong Ren, Jin-Ming Yang, Yan Cheng
Summary: This article discusses the important roles of autophagy in tumor cells, immune cells, and stromal cells in the context of tumor immunity, as well as the potential of combining autophagy-based therapy with immunotherapy as novel therapeutic approaches against cancer.
DRUG RESISTANCE UPDATES
(2021)
Review
Immunology
Qiang Dong, Eric S. Chen, Chen Zhao, Chengcheng Jin
Summary: The lung microbiome has been linked to cancer development and progression, impacting the tumor microenvironment and immune cell activity. Research in lung cancer patients and mouse models has revealed dysregulation of the local microbiome in the lung, offering new insights into lung cancer biology and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Jessica Spring, Vera Beilinson, Brian C. DeFelice, Juan M. Sanchez, Michael Fischbach, Alexander Chervonsky, Tatyana Golovkina
Summary: Both viruses and bacteria can produce molecular patterns that affect microbial pathogenesis and anti-microbial responses. In addition, bacteria produce metabolites, while viruses can change the metabolic profiles of infected cells. Using an unbiased metabolomics approach, this study found that viral infection significantly alters the metabolite profile of mice monocolonized with Lactobacillus murinus. These findings suggest that the changes in metabolites could play a role in viral pathogenesis or the host response against the virus, providing a new avenue for future investigations.
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Shengnan Li, Qian Li, Wei Lu
Summary: The intratumoral microbiome, an important component of the tumor microenvironment, plays a role in promoting immune microenvironment heterogeneity and reprogramming tumor metabolism to affect tumor invasion and metastasis. Understanding the intratumoral microbiome in gastrointestinal cancers can reveal the mechanisms of tumor development and provide a basis for developing new therapeutic approaches.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jialei Weng, Shaoqing Liu, Qiang Zhou, Wenxin Xu, Minghao Xu, Dongmei Gao, Yinghao Shen, Yong Yi, Yi Shi, Qiongzhu Dong, Chenhao Zhou, Ning Ren
Summary: In HCC, infiltrating macrophages with PPT1 expression are associated with poor prognosis and may enhance the efficacy of immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Zifan Pei, Huali Lei, Jie Wu, Wei Tang, Kailu Wei, Li Wang, Fei Gong, Nailin Yang, Lin Liu, Yuqi Yang, Liang Cheng
Summary: Bioactive inorganic nanomaterials and the biological effects of metal ions have attracted extensive attention in tumor therapy. Vanadium, as a bioactive metal element, regulates various biological functions. However, its role in antitumor therapy still needs to be revealed.
Article
Chemistry, Multidisciplinary
Lijun Yang, Dianyu Wang, Haixue Jia, Cuihong Yang, Yumin Zhang, Hui Li, Jinjian Liu, Jianfeng Liu
Summary: Tumor cells use metabolic reprogramming to create an immunosuppressive tumor microenvironment (TME) and evade the immune system. This study develops a tumor-specific peroxynitrite nanogenerator that disrupts metabolic homeostasis in melanoma cells. The produced peroxynitrite induces a decrease in metabolites in the tricarboxylic acid cycle and reduces lactate production. Mechanistically, peroxynitrite impairs glucose metabolism by affecting the activity of glyceraldehyde-3-phosphate dehydrogenase. These metabolic alterations reverse the immunosuppressive TME and promote antitumor immune responses. When combined with anti-PD-L1, the nanogenerator inhibits both primary and metastatic melanomas without causing toxicity. This research provides a new strategy for enhancing immunotherapy sensitivity.
ADVANCED MATERIALS
(2023)
Review
Immunology
Desheng Qi, Milin Peng
Summary: Cell death is a common biological process in various physiological and pathological conditions. There are multiple types of cell death, including apoptosis and the newly discovered ferroptosis. Ferroptosis has been found to have potential antitumor effects and may also impact immune cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Peng Zhang, Mingyue Liu, Ya Cui, Pan Zheng, Yang Liu
Summary: This study found that MSI-H and non-MSI-H samples exhibited clinical response and immune phenotypic differences in different cancer types. However, regardless of cancer types, the abundance of tumor-infiltrating immune cells was more strongly associated with clinical outcomes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Zhengting Jiang, Wenjie Zhang, Zhilin Zhang, Gengyu Sha, Daorong Wang, Dong Tang
Summary: Pancreatic cancer is a growing cause of cancer-related deaths, often diagnosed at advanced stages. Conventional treatments have poor results, making it difficult to treat. Microbiota and their products have shown promise in regulating pancreatic tumor microenvironment, cancer cell behavior, and immune system functionality. This review summarizes the mechanisms of intratumoral microbiota in pancreatic cancer, highlighting their potential in diagnosis and treatment. Additionally, future prospects for intratumoral microbiota in treating pancreatic cancer are discussed.
Article
Cell Biology
Yiyi Liang, Huimin Li, Yu Gan, Hong Tu
Summary: Pancreatic cancer is a highly lethal malignancy with a low survival rate, and its development is influenced by the tumor microenvironment. Neurotransmitters can directly regulate the biological behavior of cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Xu Guo, Gang Wang
Summary: This review explores the mechanisms by which glioma cells suppress antitumor immune responses and produce escape, with a focus on immune cell differentiation and function in the tumor microenvironment. A deeper understanding of immune response and evasion mechanisms in glioma is needed to develop more effective treatment modalities.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Alexander Visekruna, Maik Luu
Summary: Research in the past decade has shown that microbiota-derived metabolites, such as short-chain fatty acids (SCFA) and secondary bile acids (BAs), play a role in inflammation and carcinogenesis. These bacterial metabolites have diverse mechanisms that regulate immunometabolism and histone deacetylase (HDAC) activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Hanna Leister, Felix F. Krause, Rouzbeh Mahdavi, Ulrich Steinhoff, Alexander Visekruna
Summary: The participation of proteasomes in vital cellular and metabolic processes that are involved in tumor growth has made them an attractive target for cancer treatment. Immunoproteasomes have been found to play an important role in tumor development, either promoting inflammation and tumor growth or supporting anti-cancer immunity.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2022)
Article
Cell Biology
Maik Luu, Kai Binder, Sabrina Hartmann, Meike Kespohl, Jasmin Bazant, Rossana Romero, Burkhard Schuetz, Ulrich Steinhoff, Alexander Visekruna
Summary: The transcription factor c-Rel is essential for regulating intestinal immune responses by controlling Tfh cell function and IgA production, contributing to intestinal homeostasis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Oncology
Emmanuel Donnadieu, Maik Luu, Miriam Alb, Brigitte Anliker, Silvia Arcangeli, Chiara Bonini, Biagio De Angelis, Rashmi Choudhary, David Espie, Anne Galy, Cam Holland, Zoltan Ivics, Chahrazade Kantari-Mimoun, Marie Jose Kersten, Ulrike Koehl, Chantal Kuhn, Bruno Laugel, Franco Locatelli, Ibtissam Marchiq, Janet Markman, Marta Angiola Moresco, Emma Morris, Helene Negre, Concetta Quintarelli, Michael Rade, Kristin Reiche, Matthias Renner, Eliana Ruggiero, Carmen Sanges, Hans Stauss, Maria Themeli, Jan Van den Brulle, Michael Hudecek, Monica Casucci
Summary: The article introduces current preclinical models used to test the safety of engineered T cells, emphasizes the limitations of existing models, and proposes potential measures for improvement.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Sonia Guedan, Maik Luu, Delphine Ammar, Paula Barbao, Chiara Bonini, Philippe Bousso, Christian J. Buchholz, Monica Casucci, Biagio De Angelis, Emmanuel Donnadieu, David Espie, Beatrice Greco, Richard Groen, Johannes B. Huppa, Chahrazade Kantari-Mimoun, Bruno Laugel, Mary Mantock, Janet L. Markman, Emma Morris, Concetta Quintarelli, Michael Rade, Kristin Reiche, Alba Rodriguez-Garcia, Juan Roberto Rodriguez-Madoz, Eliana Ruggiero, Maria Themeli, Michael Hudecek, Ibtissam Marchiq
Summary: Immunotherapy with gene engineered CAR and TCR transgenic T-cells is a groundbreaking treatment in cancer medicine, and has the potential to be used in common solid tumors. However, in order to improve and accelerate the selection of lead T-cell products for clinical translation, it is necessary to assess preclinical models and develop new models with higher predictive value.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Immunology
Paulin Brosinsky, Hanna Leister, Nan Cheng, Xaralabos Varelas, Alexander Visekruna, Maik Luu
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carmen Schiweck, Sharmili Edwin Thanarajah, Mareike Aichholzer, Silke Matura, Andreas Reif, Elske Vrieze, Andreas Weigert, Alexander Visekruna
Summary: The gut microbiota produces a variety of enzymes that can synthesize different metabolites, including short-chain fatty acids (SCFAs). Recent research has revealed a central role for microbe-derived SCFAs in the interaction between gut microbiota and the host, directly affecting the metabolic activity and epigenetic status of host T lymphocytes. SCFAs play a crucial biological role in promoting the development of regulatory T cells and the production of the anti-inflammatory cytokine interleukin-10 (IL-10). These small molecules can also circulate and modulate immune cell function in distant tissues, showing therapeutic potential in autoimmune and inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Lopez Krol, Hannah P. Nehring, Felix F. Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho-Ryun Chung, Uta-Maria Bauer, Till Adhikary, Alexander Visekruna
Summary: This study indicates that lactate can induce changes in the gene expression program of Th17 cells by modulating their metabolism and epigenetic status, resulting in a shift in their function.
Article
Microbiology
Rossana Romero, Agnieszka Zarzycka, Mathieu Preussner, Florence Fischer, Torsten Hain, Jan-Paul Herrmann, Katrin Roth, Corinna U. Keber, Kushal Suryamohan, Hartmann Raifer, Maik Luu, Hanna Leister, Wilhelm Bertrams, Matthias Klein, Hosam Shams-Eldin, Ralf Jacob, Hans-Joachim Mollenkopf, Krishnaraj Rajalingam, Alexander Visekruna, Ulrich Steinhoff
Summary: Colonization with selected commensal microbes can restore the immune response in adult carrier mice, facilitated by the activation and development of the intestinal blood vessel system and the immune system.
Meeting Abstract
Immunology
M. Luu, S. Staudt, Z. Riester, J. Franz, S. Danhof, T. Nerreter, I. E. Mulder, U. Steinhoff, M. Hudecek, A. Visekruna
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
R. V. Romero Perez, A. Zarzycka, M. Preussner, F. Fischer, K. Roth, C. U. Keber, K. Suryamohan, H. Raifer, M. Luu, H. Leister, W. Bertrams, M. Klein, H. Shams-Eldin, R. Jacob, H. -J. Mollenkopf, K. Rajalingam, A. Visekruna, U. Steinhoff
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Cell & Tissue Engineering
M. Luu, S. Carmen, A. Draper, N. Hoen, S. Sheth, S. Wagers, H. Negre, M. Hudecek