Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

(2016) Shivaani Kummar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

(2016) Yuna Kim et al.   NATURE MEDICINE

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

(2016) Angela M. Mabb et al.   PLoS One

Cancer-treatment-induced neurotoxicity—focus on newer treatments

(2015) Jacqueline B. Stone et al.   Nature Reviews Clinical Oncology

Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indotecan (LMP400) and Indimitecan (LMP776)

(2014) Daniel E. Beck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topoisomerase 1 inhibition reversibly impairs synaptic function

(2014) Angela M. Mabb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

(2013) S. Solier et al.   CANCER RESEARCH

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons

(2012) Maris A. Cinelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

(2011) Hsien-Sung Huang et al.   NATURE

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

(2011) Angela M. Mabb et al.   TRENDS IN NEUROSCIENCES

Behavior and neuropsychiatric manifestations in Angelman syndrome

(2011) Bernard Dan   Neuropsychiatric Disease and Treatment

Development of a Validated Immunofluorescence Assay for  H2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity

(2010) R. J. Kinders et al.   CLINICAL CANCER RESEARCH

Angelman syndrome: advancing the research frontier of neurodevelopmental disorders

(2010) Benjamin D. Philpot et al.   Journal of Neurodevelopmental Disorders

A phase II study of metronomic oral topotecan for recurrent childhood brain tumors

(2010) Jane E. Minturn et al.   PEDIATRIC BLOOD & CANCER

Angelman syndrome: Current understanding and research prospects

(2009) Bernard Dan   EPILEPSIA

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

(2009) Y. Pommier et al.   MOLECULAR CANCER THERAPEUTICS

Topoisomerase I inhibitors for the treatment of brain tumors

(2008) Lynn Feun et al.   Expert Review of Anticancer Therapy