Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

(2022) Derek VanDyke et al.   Cell Reports

Biodegradable Cationic Polymer Blends for Fabrication of Enhanced Artificial Antigen Presenting Cells to Treat Melanoma

(2021) Kelly R. Rhodes et al.   ACS Applied Materials & Interfaces

Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies

(2020) Takashi Kei Kishimoto   Frontiers in Immunology

Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction

(2020) Kelly R. Rhodes et al.   Acta Biomaterialia

Engineering IL-2 to Give New Life to T Cell Immunotherapy

(2020) Willem W. Overwijk et al.   Annual Review of Medicine

Exploiting PLGA-Based Biocompatible Nanoparticles for Next-Generation Tolerogenic Vaccines against Autoimmune Disease

(2019) Giuseppe Cappellano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methods to manufacture regulatory T cells for cell therapy

(2019) Katherine N. MacDonald et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases

(2019) Maryam Tahvildari et al.   JOURNAL OF IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance

(2018) Takashi Kei Kishimoto et al.   Frontiers in Immunology

Natural and modified IL-2 for the treatment of cancer and autoimmune diseases

(2018) Masayuki Mizui   CLINICAL IMMUNOLOGY

Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity

(2016) James I. Andorko et al.   Cellular and Molecular Bioengineering

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

(2015) James D. Fisher et al.   CLINICAL IMMUNOLOGY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis

(2014) Giuseppe Cappellano et al.   VACCINE

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Nanoparticle Delivery of Mycophenolic Acid Upregulates PD-L1 on Dendritic Cells to Prolong Murine Allograft Survival

(2011) A. C. Shirali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Current landscape for T-cell targeting in autoimmunity and transplantation

(2011) Daniel R Getts et al.   Immunotherapy

An Artificial Antigen-presenting Cell with Paracrine Delivery of IL-2 Impacts the Magnitude and Direction of the T Cell Response

(2011) Erin R. Steenblock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Drug delivery systems: Advanced technologies potentially applicable in personalized treatments

(2010) Jorge F. Coelho et al.   EPMA Journal

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology