Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

(2022) Alison Tarke et al.   CELL

mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern

(2022) Paulina Kaplonek et al.   IMMUNITY

Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants

(2022) Emma K. Accorsi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

(2022) Sandile Cele et al.   NATURE

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

(2022) Peter J. Halfmann et al.   NATURE

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

(2022) Guillaume Beaudoin-Bussières et al.   Cell Reports

Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

(2022) Baoling Ying et al.   CELL

SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

(2022) Simone I. Richardson et al.   Cell Host & Microbe

Inflammasome activation in infected macrophages drives COVID-19 pathology

(2022) Esen Sefik et al.   NATURE

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

(2022) Caroline Junqueira et al.   NATURE

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

(2022) Chunfeng Li et al.   NATURE IMMUNOLOGY

Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

(2022) Nick Andrews et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions

(2022) Paulina Kaplonek et al.   Science Translational Medicine

Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

(2022) Zhenlu Chong et al.   Cell Reports

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates

(2022) Daniel Y. Zhu et al.   PLOS BIOLOGY

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5

(2022) Qian Wang et al.   NATURE

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

(2022) James Brett Case et al.   Nature Communications

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans

(2022) Zijun Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination

(2022) Nadia Brasu et al.   NATURE IMMUNOLOGY

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

(2022) Suzanne M. Scheaffer et al.   NATURE MEDICINE

A Bivalent Omicron-Containing Booster Vaccine against Covid-19

(2022) Spyros Chalkias et al.   NEW ENGLAND JOURNAL OF MEDICINE

BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age

(2022) Timothy A. Bates et al.   Cell Reports

Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster

(2022) Meredith E. Davis-Gardner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mapping and role of T cell response in SARS-CoV-2–infected mice

(2021) Zhen Zhuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

(2021) Emma S. Winkler et al.   CELL

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

(2021) Rita E. Chen et al.   NATURE MEDICINE

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

(2021) Fatima Amanat et al.   CELL

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

(2021) Laura A. VanBlargan et al.   IMMUNITY

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

(2021) Rachel Yamin et al.   NATURE

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

(2021) Rita E. Chen et al.   NATURE

mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar

(2021) Hiam Chemaitelly et al.   NATURE MEDICINE

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice

(2021) Emma S. Winkler et al.   JOURNAL OF VIROLOGY

Detection of persistent SARS-CoV-2 IgG antibodies in oral mucosal fluid and upper respiratory tract specimens following COVID-19 mRNA vaccination

(2021) Aubree Mades et al.   Scientific Reports

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

(2020) Hongjing Gu et al.   SCIENCE

Impact of mRNA chemistry and manufacturing process on innate immune activation

(2020) Jennifer Nelson et al.   Science Advances

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Growth, detection, quantification, and inactivation of SARS-CoV-2

(2020) James Brett Case et al.   VIROLOGY

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

(2020) Tomer Zohar et al.   CELL

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

A Restricted Role for FcγR in the Regulation of Adaptive Immunity

(2018) Marieke F. Fransen et al.   JOURNAL OF IMMUNOLOGY

Systems serology for evaluation of HIV vaccine trials

(2017) Margaret E. Ackerman et al.   IMMUNOLOGICAL REVIEWS

Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles

(2017) Eric P. Brown et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

Fc RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

(2010) F. Nimmerjahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA