Article
Chemistry, Physical
Takayoshi Ishimoto, Hiroki Sakagami, Yusuke Kanematsu, Masanori Tachikawa
Summary: This study investigated the effects of H/D isotope on the adsorption of water molecules on ice surfaces by considering the nuclear quantum effects of protons and deuterons using the CPLB method. It was found that the H/D isotope effect resulted in longer hydrogen bonds and weaker adsorption energies for D2O and HDO molecules compared to H2O, leading to geometrical changes on the adsorbed water and ice surfaces.
APPLIED SURFACE SCIENCE
(2021)
Article
Energy & Fuels
Jia Liu, Jing Wang, Ti Dong, Deqing Liang
Summary: The formation of wax crystals and hydrates in deep-sea crude oil can affect the nucleation, growth, aggregation, and crystal structure of hydrates. Specifically, wax crystals inhibit hydrate formation, while hydrate formation reduces wax crystal aggregation, improving the flow characteristics of the hydrate slurry. Wax has no effect on the crystal structure of CH4 hydrate but impacts the distribution of the gas in cavities.
Article
Chemistry, Physical
Mohammad Tariq, Mario R. C. Soromenho, Manuel M. Pineiro, Martin Perez-Rodriguez, Dalip Kumar, Ana Rodriguez, Francisco J. Deive, Jose M. S. S. Esperanca
Summary: In this study, the phase equilibria of CO2 hydrates in H2O, D2O, and their binary mixtures were investigated. The results showed that there is a difference in the equilibrium line of CO2 hydrates formed in H2O and D2O, but the hydrate dissociation enthalpies were similar. The study also revealed the influence of isotopic effect on CO2 hydrate formation and dissociation, which may have implications for separation and purification processes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Energy & Fuels
Yijie Wang, Qiyu Huang, Dongxu Zhang, Kun Wang, Xun Zhang, Yu Zhang, Zhenkang Xu, WenChen Liu
Summary: This study investigates the influence of asphaltenes on the evolution behavior of CO2 hydrates in waxy water-in-oil emulsions using a lab scale high-pressure stirring reactor. The results show that waxes inhibit CO2 hydrate nucleation, while the addition of asphaltenes enhances this inhibition effect. Moreover, asphaltenes facilitate the decomposition process of CO2 hydrates in waxy systems.
Article
Multidisciplinary Sciences
Anna Stefaniuk, Sylwester Gawinkowski, Barbara Golec, Aleksander Gorski, Kosma Szutkowski, Jacek Waluk, Jaroslaw Poznanski
Summary: The isotope effect significantly influences the behavior of a single molecule in a solution, and the interaction between solvents and solutes differs between H2O and D2O.
SCIENTIFIC REPORTS
(2022)
Article
Energy & Fuels
Xianwen Cheng, Qiyu Huang, Dongxu Zhang, Yang Lyu, Wei Wang, Rongbin Li, Yijie Wang, Qiuchen Wang
Summary: The study found that the polarity of asphaltene has a significant impact on the behavior of hydrates, with higher polarity subfractions showing a higher tendency for self-aggregation in emulsions. Additionally, the induction time and the amount of formed hydrate are influenced by the presence of asphaltenes, with the effect being more pronounced in emulsions with less polar subfractions. Furthermore, asphaltene subfractions are observed to accelerate the dissociation process of hydrates.
Article
Chemistry, Inorganic & Nuclear
Xueguang Liu, Wei Liu, Zhenghua Ju, Jie Jiang, Weisheng Liu
Summary: A new hydrophilic mixed Lanthanide metal-organic framework (Ln-MOF) was designed and built for monitoring the H2O content in D2O, showing a change in photoluminescence color from yellow to green, which can be observed by the naked eye.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Norihito Kimizuka
Summary: Research shows that a metastable eutectic is formed when an NaCl aqueous solution is cooled as a water-in-oil emulsion, with a eutectic point around -28 degrees C. This phenomenon can be predicted using phase diagrams.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Food Science & Technology
Rajinder Pal
Summary: Emulsions play a crucial role in food products and understanding their rheological properties, especially shear viscosity, is important for their design, formulation, and processing. Texture and mouthfeel of emulsions are greatly influenced by their viscosity. This article provides a review of recent developments in viscosity modeling of concentrated emulsions, discussing and evaluating various models published in the twenty-first century using experimental viscosity data. The effects of droplet size distribution and capillary number on emulsion viscosity are also discussed.
Article
Materials Science, Multidisciplinary
Bhumin Than-ardna, Christoph Weder, Hathaikarn Manuspiya
Summary: Modified bacterial cellulose (BC) derived from Nata de coco waste was used to develop environmentally friendly superhydrophilic BC membranes with efficient oil removal properties. Spherical SiO2 nanoparticles were synthesized and deposited on the surface of the BC membranes to enhance their surface roughness and wettability. The modified BC membranes exhibited high water flux, separation efficiency, mechanical properties, reusability, antifouling properties, and stability, making them promising for practical application in emulsion wastewater treatment.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Physical
Dhanadeep Dutta, A. K. Bera, Priya Maheshwari, Siddhartha Kolay, S. M. Yusuf, P. K. Pujari
Summary: The study demonstrates the evolution of almost pure cubic ice structure within the nanopores of a hydrostable metal-organic framework. This finding is important for understanding the microphysics of ice cloud formation in the atmosphere.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Jianzhong Jiang, Shijie Yu, Wanqing Zhang, Haojie Zhang, Zhenggang Cui, Wenshui Xia, Bernard P. Binks
Summary: The novel charge-reversible surfactant can stabilize smart n-octane-in-water emulsions responsive to pH by transforming from anionic carboxylate to cationic form at different pH values. This allows for intelligent and precise control of stability, viscosity, and droplet size of the emulsions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Lingfeng Long, Yun Hu, Le Xie, Fubao Sun, Zhenghong Xu, Jinguang Hu
Summary: The study demonstrates a convenient and effective approach for designing a bacterial sensor platform based on bacterial cellulose through CBM2a-assisted cell adhesion strategy, achieving efficient immobilization and sensitive detection of target analyte.
Article
Chemistry, Multidisciplinary
Zhiqiang Guo, Xiaoxuan Fan, Xiaokun Wen, Wen Liu, Baijie Guan, Xia Hong, Kexin Wang, Jiwei Wang
Summary: An anomalous solvent-induced luminescence quenching of NH2-MIL-53(Fe) in D2O is reported. This quenching is not caused by protonation or high-frequency vibrations of solvent molecules, but due to the inhibition of charge transfer by hydrogen bonding between NH2-MIL-53(Fe) and D2O. This discovery enables accurate quantitative detection of specific volume fractions of D2O in H2O.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Zhengang Han, Juxia Wang, Peiyao Du, Jing Chen, Shuhui Huo, Huixia Guo, Xiaoquan Lu
Summary: Distinguishing between water (H2O) and deuteroxide (D2O) is a challenging task due to their similarities in size, shape, and chemical reactivity. This study investigates the enhanced optical properties of a water-soluble porphyrin in D2O and proposes a convenient method for distinguishing between H2O and D2O using electrochemiluminescence (ECL) analysis, which shows a lower detection limit.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Reinier J. de Vries, Shannon N. Tessier, Peony D. Banik, Sonal Nagpal, Stephanie E. J. Cronin, Sinan Ozer, Ehab O. A. Hafiz, Thomas M. van Gulik, Martin L. Yarmush, James F. Markmann, Mehmet Toner, Heidi Yeh, Korkut Uygun
Article
Multidisciplinary Sciences
Galit H. Frydman, Shannon N. Tessier, Keith H. K. Wong, Charles R. Vanderburg, James G. Fox, Mehmet Toner, Ronald G. Tompkins, Daniel Irimia
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Lindong Weng
Summary: Cell-based therapeutics have shown promising results in treating various diseases, but the temporal and spatial distances between manufacture and administration may pose risks of potency degradation. Cryopreservation has become a common method for maintaining product safety and efficacy, yet it could limit patient access and increase logistics costs. Research on freeze-drying or drying of mammalian cells is growing, paving the way for potential dry-state preservation of cell-based therapeutics in biomanufacturing.
BIOPRESERVATION AND BIOBANKING
(2021)
Article
Biochemistry & Molecular Biology
Shannon N. Tessier, Sarah A. Breedon, Kenneth B. Storey
Summary: Mammalian hibernators undergo significant changes in behavior, physiology, and biochemistry to survive the challenges of low temperature, ischemia-reperfusion, and limited fuel reserves during days or weeks of hibernation. Antioxidant defenses, regulated by proteins like Nrf2, play a critical role in mitigating oxidative stress during torpor and arousal. The study found that during hibernation, changes in protein levels and interactions, such as an increase in MafK leading to higher Nrf2 and catalase levels during arousal, are responsive to cycles of torpor-arousal, showing peak responses during arousal.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Multidisciplinary Sciences
Shannon N. Tessier, Lauren D. Bookstaver, Cindy Angpraseuth, Cleo J. Stannard, Beatriz Marques, Uyen K. Ho, Alona Muzikansky, Berent Aldikacti, Eduardo Reategui, Daniel C. Rabe, Mehmet Toner, Shannon L. Stott
Summary: Extracellular vesicles (EVs) are potential candidates for biomarker discovery and diagnostics. Cryopreservation of EV-containing samples at -80 degrees C for up to 12 days resulted in a significant decrease in EV concentration and RNA yield in both plasma- and media-derived samples. Direct comparison between fresh and cryopreserved samples without cryoprotectant agents showed significant losses in total RNA, but the addition of DMSO and controlled cooling/warming rates improved RNA yield.
Book Review
Surgery
Benjamin T. Wilks, Mehmet Toner, Shannon N. Tessier
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Laura C. Burlage, Alexandre G. Lellouch, Corentin B. Taveau, Philipp Tratnig-Frankl, Casie A. Pendexter, Mark A. Randolph, Robert J. Porte, Laurent A. Lantieri, Shannon N. Tessier, Curtis L. Cetrulo, Korkut Uygun
Summary: This study developed a protocol for ex vivo subnormothermic oxygenated machine perfusion of rodent hindlimbs and validated its efficacy in a heterotopic hindlimb transplant model. The results showed that perfusion with the acellular oxygen carrier HBOC-201 resulted in superior tissue preservation compared to conventional SCS.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kristin J. Adolfsen, Isolde Callihan, Catherine E. Monahan, Per Greisen, James Spoonamore, Munira Momin, Lauren E. Fitch, Mary Joan Castillo, Lindong Weng, Lauren Renaud, Carl J. Weile, Jay H. Konieczka, Teodelinda Mirabella, Andres Abin-Fuentes, Adam G. Lawrence, Vincent M. Isabella
Summary: In this study, a more potent EcN-based PKU strain was developed through the optimization of whole cell PAL activity, showcasing approximately two-fold increase in in vivo PAL activity compared to the previous strain. The biosensor-based ultra-high-throughput screening approach utilized in this study could potentially lead to improved in vivo performance for PKU treatment in the future.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Shannon N. Tessier, Reinier J. de Vries, Casie A. Pendexter, Stephanie E. J. Cronin, Sinan Ozer, Ehab O. A. Hafiz, Siavash Raigani, Joao Paulo Oliveira-Costa, Benjamin T. Wilks, Manuela Lopera Higuita, Thomas M. van Gulik, Osman Berk Usta, Shannon L. Stott, Heidi Yeh, Martin L. Yarmush, Korkut Uygun, Mehmet Toner
Summary: This study reports a technique using partial freezing to extend the preservation duration of organs, achieved by controlling ice formation and maintaining a liquid state using ice nucleators and cryoprotective agents. The results indicate that propylene glycol outperforms glycerol and machine perfusion enhancements improve the recovery of frozen livers.
NATURE COMMUNICATIONS
(2022)
Meeting Abstract
Hematology
Xiaomeng Hu, Pascal Beauchesne, Karl Manner, Corie Gattis, Priscilla Ngo, Rowena De Jesus, Chi Young, Frank Wells, Lindong Weng, Kathy White, William E. Dowdle, Aaron Foster, Terry Fry, Sonja Schrepfer
Article
Physics, Multidisciplinary
Shannon N. Tessier, Omar Haque, Casie A. Pendexter, Stephanie E. J. Cronin, Ehab O. A. Hafiz, Lindong Weng, Heidi Yeh, James F. Markmann, Michael J. Taylor, Gregory M. Fahy, Mehmet Toner, Korkut Uygun
Summary: Introduction: The current shortage of liver organs has led to the development of new methods to prolong liver preservation time. The study introduces partial freezing as an approach to achieve a thermodynamically stable frozen state at high subzero temperatures, while maintaining a sufficient unfrozen fraction to limit ice-mediated injury. Methods and results: The study demonstrates that partially frozen rat livers using glycerol as the cryoprotectant show similar outcomes after thawing at -10 degrees C or -15 degrees C. Adding ice modulators, such as antifreeze glycoprotein (AFGP) or a polyvinyl alcohol/polyglycerol combination (X/Z-1000), improves viability but also leads to cell damage and edema. Further research is needed to optimize the ideal ice modulator cocktail for the partial-freezing protocol. Discussion: Modifying cryoprotective agent combinations and testing additional ice modulators can enhance the viability of partially frozen organs.
FRONTIERS IN PHYSICS
(2022)
Article
Multidisciplinary Sciences
Ziya Isiksacan, Angelo D'Alessandro, Susan M. Wolf, David H. McKenna, Shannon N. Tessier, Erdem Kucukal, A. Aslihan Gokaltun, Nishaka William, Rebecca D. Sandlin, John Bischof, Narla Mohandas, Michael P. Busch, Caglar Elbuken, Umut A. Gurkan, Mehmet Toner, Jason P. Acker, Martin L. Yarmush, O. Berk Usta
Summary: Transfusion of red blood cells is a valuable and widespread treatment in modern medicine. Current practices in blood transfusion overlook the variability in stored red blood cell quality. It is necessary to rethink transfusion medicine workflows and utilize novel technologies for assessing red blood cell quality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Surgery
Manuela Lopera Higuita, Rohil Jain, Asishana A. A. Osho, S. Alireza Rabi, Timothy L. L. Pruett, Richard N. N. Pierson III, Paul A. A. Iaizzo, Shannon N. N. Tessier
Summary: The current lack of objective and quantitative assessment techniques for cardiac graft viability leads to risk-averse decision-making, negatively impacting the utilization of cardiac grafts. This review aims to highlight the deficiencies in cardiac allograft assessment and explore novel assessment techniques utilizing imaging modalities such as ultrasound, magnetic resonance, and spectroscopy.
CURRENT TRANSPLANTATION REPORTS
(2023)
Meeting Abstract
Hematology
Christina Chaivorapol, Pascal Beauchesne, Rowena De Jesus, William E. Dowdle, Xiaoyu Chen, Alison Bayley, Yunjiang Qiu, Andrew Birnberg, Yu Zheng, Antonino Montalbano, Angela Liu, Misbah Zafar, Karl Manner, Ramya Ankala, Eleonore Tham, Heer Shah, Ben Lam, Jaclyn Lock, Lindong Weng, Kate Watts, Amanda Valdiosera, Kimberly Davis, Lei Wang, Divy Kangeyan, Nicolas Devos, Athena Wong, Jason Lih, Edward J. Rebar
Review
Cardiac & Cardiovascular Systems
Luciana Da Silveira Cavalcante, Shannon N. Tessier
Summary: Heart transplantation emerged as a life-saving option for patients with end-stage heart failure in the late 1960s. While traditional cold storage methods offer only short-term heart preservation, new technologies aim at extending ex vivo lifespan. Limited research tools pose a barrier for experimental efforts, with smaller vertebrate models like zebrafish potentially filling critical gaps in research.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)