Journal
LANGMUIR
Volume 32, Issue 7, Pages 1854-1862Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b04166
Keywords
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Funding
- MINECO [MAT2010-17016, MAT2013-47902-C2-1-R]
- Ministerio de Educacion
- DAAD [A/13/71498]
- Bundesministerium fur Bildung and Forschung (BMBF) [13N12561]
- Helmholtz Virtual Institute, Multifunctional Biomaterials for Medicine
- Freie Universitat Focus Area Nanoscale
- Alexander von Humboldt Foundation
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In this article, we describe the formation of functional honeycomb like porous surfaces fabricated by the breath figures technique using blends of either amino-terminated poly(styrene) or a poly(styrene)-b-poly(acrylic acid) block copolymer with homopoly(styrene). Thus, the porous interfaces exhibited either amino or acid groups selectively located inside of the holes, which were subsequently employed to anchor stimuli-responsive nanogels by electrostatic interactions. These nanogels were prepared from poly(N-isopropylacrylamide) (PNIPAM) cross-linked with dendritic polyglycerol (dPG) and semi-interpenetrated with either 2-(dimethylamino)ethyl methacrylate (DMAEMA) or 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) to produce positively and negatively charged nanogel surfaces, respectively. The immobilization of these semi-interpenetrated networks onto the surfaces allowed us to have unique stimuli responsive surfaces with both controlled topography and composition. More interestingly, the surfaces exhibited stimuli-responsive behavior by variations on the pH or temperature. Finally, the surfaces were evaluated regarding their capacity to induce a thermally triggered protein release at temperatures above the cloud point temperature (T-cp) of the nanogels.
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