Journal
LANGMUIR
Volume 32, Issue 33, Pages 8501-8506Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.6b01482
Keywords
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Funding
- NSF [CBET-1254795]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1254795] Funding Source: National Science Foundation
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A self-assembled phospholipid monolayer at an air water interface is a well-defined model system for studying surface thermodynamics, membrane biophysics, thin-film materials, and colloidal soft matter. Here we report a study of two-dimensional phase transitions in the dipalmitoylphosphatidylcholine (DPPC) monolayer at the air water interface using a newly developed methodology called constrained drop surfactometry (CDS). CDS is superior to the classical Langmuir balance in its capacity for rigorous temperature control and leak-proof environments, thus making it an ideal alternative to the Langmuir balance for studying lipid polymorphism. In addition, we have developed a novel Langmuir-Blodgett (LB) transfer technique that allows the direct transfer of lipid monolayers from the droplet surface under well-controlled conditions. This LB transfer technique permits the direct visualization of phase coexistence in the DPPC monolayer. With these technological advances, we found that the two-dimensional phase behavior of the DPPC monolayer is analogous to the three-dimensional phase transition of a pure substance. This study has implications in the fundamental understanding of surface thermodynamics as well as applications such as self-assembled monolayers and pulmonary surfactant biophysics.
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