siRNA targeting ANGPTL3 stands in the spotlight for lipid-lowering therapy

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

(2022) Bo Hu et al.   Science Advances

siRNA modification and delivery for drug development

(2022) Mengjie Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

(2022) Jue Wang et al.   Molecular Therapy-Nucleic Acids

Global epidemiology of dyslipidaemias

(2021) Angela Pirillo et al.   Nature Reviews Cardiology

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events

(2010) Takashi Miida et al.   CURRENT OPINION IN LIPIDOLOGY