Mode of Action of Heat Shock Protein (HSP) Inhibitors against Viruses through Host HSP and Virus Interactions

Heat shock protein 70 (HSP70) plays important role in tembusu virus infection

(2022) Ge Dai et al.   VETERINARY MICROBIOLOGY

Genome-Wide Identification and Characterization of Heat Shock Protein 20 Genes in Maize

(2022) Huanhuan Qi et al.   Life-Basel

Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors

(2021) Chih-Shiang Chang et al.   CURRENT MEDICINAL CHEMISTRY

A chloroplast heat shock protein modulates growth and abiotic stress response in creeping bentgrass

(2021) Xinbo Sun et al.   PLANT CELL AND ENVIRONMENT

Dihydromyricetin Imbues Antiadipogenic Effects on 3T3-L1 Cells via Direct Interactions with 78-kDa Glucose-Regulated Protein

(2021) Binmei Sun et al.   JOURNAL OF NUTRITION

Structural basis of substrate recognition and thermal protection by a small heat shock protein

(2021) Chuanyang Yu et al.   Nature Communications

Computational investigation of ginkgetin and theaflavin as potential inhibitors of heat shock protein 90 (Hsp90)

(2021) Kinjal Bhadresha et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90

(2020) Andraž Lamut et al.   BIOORGANIC CHEMISTRY

Heat Shock Protein 90 Inhibitors Suppress Pyroptosis in THP-1 Cells

(2020) Zhou Zhou et al.   BIOCHEMICAL JOURNAL

Heat shock protein 19.9 (Hsp19.9) from Bombyx mori is involved in host protection against viral infection

(2020) Liang Jiang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Heat Shock Protein Member 8 Is an Attachment Factor for Infectious Bronchitis Virus

(2020) Pengpeng Zhu et al.   Frontiers in Microbiology

Development of an oil-in-water emulsion stabilized by a black bean protein-based nanocomplex for co-delivery of quercetin and perilla oil

(2020) Lu Han et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

(2019) Sujit Pujhari et al.   Emerging Microbes & Infections

Heat Shock Protein 90 Ensures the Integrity of Rubella virus p150 Protein and Supports Viral Replication

(2019) Masafumi Sakata et al.   JOURNAL OF VIROLOGY

Impact of nanosizing on dermal delivery and antioxidant activity of quercetin nanocrystals

(2019) Maria Letizia Manca et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Heat shock protein 70 and heat shock protein 90 synergistically increase hepatitis B viral capsid assembly

(2018) Hyun Wook Seo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpressing heat-shock protein OsHSP50.2 improves drought tolerance in rice

(2018) Jianhua Xiang et al.   PLANT CELL REPORTS

Triticum aestivum heat shock protein 23.6 interacts with the coat protein of wheat yellow mosaic virus

(2018) Shanshan Jiang et al.   VIRUS GENES

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro

(2018) Tiantian Xu et al.   MICROBIAL PATHOGENESIS

Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27

(2017) Soo-Yeon Hwang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quercetin and derivatives: useful tools in inflammation and pain management

(2017) Gabriele Carullo et al.   Future Medicinal Chemistry

Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation

(2017) Hiroshi Katoh et al.   JOURNAL OF VIROLOGY

Antiviral Activity of Paulownia tomentosa against Enterovirus 71 of Hand, Foot, and Mouth Disease

(2015) Ping Ji et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of heat shock cognate protein 70 gene (Alhsc70) ofApolygus lucorumand its expression in response to different temperature and pesticide stresses

(2015) Yang Sun et al.   Insect Science

Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial

(2015) James I Dower et al.   JOURNAL OF NUTRITION

Activation ofTomato Bushy Stunt VirusRNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by PhospholipidsIn Vitro

(2015) Judit Pogany et al.   JOURNAL OF VIROLOGY

Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection

(2015) Syed Benazir Alam et al.   JOURNAL OF VIROLOGY

Quercetin Affects Hsp70/IRE1αMediated Protection from Death Induced by Endoplasmic Reticulum Stress

(2015) Antonello Storniolo et al.   Oxidative Medicine and Cellular Longevity

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

(2015) Wenjiao Wu et al.   Viruses-Basel

Interaction of HSP20 with a viral RdRp changes its sub-cellular localization and distribution pattern in plants

(2015) Jing Li et al.   Scientific Reports

Genome-wide analysis and expression profiling under heat and drought treatments of HSP70 gene family in soybean (Glycine max L.)

(2015) Ling Zhang et al.   Frontiers in Plant Science

Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines

(2015) Zhikui Cheng et al.   VIROLOGICA SINICA

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza

(2015) Ahmed Abdal Dayem et al.   PLoS One

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

(2014) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro

(2014) Jintao Gao et al.   BMC MICROBIOLOGY

DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity

(2014) M. Cao et al.   JOURNAL OF VIROLOGY

Heat shock protein 70 is necessary forRice stripe virusinfection in plants

(2014) Shanshan Jiang et al.   MOLECULAR PLANT PATHOLOGY

Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for Pepino mosaic virus Capsid Protein

(2014) Matthaios M. Mathioudakis et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Bioavailability of Quercetin: Problems and Promises

(2013) X. Cai et al.   CURRENT MEDICINAL CHEMISTRY

Identification of Novel Host Factors via Conserved Domain Search: Cns1 Cochaperone Is a Novel Restriction Factor of Tombusvirus Replication in Yeast

(2013) Jing-Yi Lin et al.   JOURNAL OF VIROLOGY

Recruitment of the Host Plant Heat Shock Protein 70 by Tomato Yellow Leaf Curl Virus Coat Protein Is Required for Virus Infection

(2013) Rena Gorovits et al.   PLoS One

Heat Shock Protein 70 Is Associated with Replicase Complex of Japanese Encephalitis Virus and Positively Regulates Viral Genome Replication

(2013) Jing Ye et al.   PLoS One

Aggregate reactivation mediated by the Hsp100 chaperones

(2012) Michal Zolkiewski et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Geldanamycin and its derivatives as Hsp90 inhibitors

(2012) Magdalena Gorska   Frontiers in Bioscience-Landmark

Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis

(2012) Dong-Jo Chang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Roles of Hsp70 and Hsp90 in the Assembly of the Replicase Complex of a Positive-Strand RNA Plant Virus

(2012) A. Mine et al.   JOURNAL OF VIROLOGY

Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells

(2012) Su-Feng Chen et al.   PLoS One

Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms

(2012) Abigail J. Larson et al.   Advances in Nutrition

Hsp90 Interacts Specifically with Viral RNA and Differentially Regulates Replication Initiation of Bamboo mosaic virus and Associated Satellite RNA

(2012) Ying Wen Huang et al.   PLoS Pathogens

Synthesis and antiviral activity of substituted quercetins

(2011) Mahendra Thapa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3)

(2011) Dipanjan Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Pepino mosaic virus capsid protein interacts with a tomato heat shock protein cognate 70

(2011) Matthaios M. Mathioudakis et al.   VIRUS RESEARCH

Inhibition of influenza virus replication by plant-derived isoquercetin

(2010) Yunjeong Kim et al.   ANTIVIRAL RESEARCH

Inhibition of heat-shock protein 90 reduces Ebola virus replication

(2010) Darci R. Smith et al.   ANTIVIRAL RESEARCH

Identification and initial SAR of silybin: An Hsp90 inhibitor

(2010) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

(2010) Phan LCHB Tran et al.   BMC CANCER

Heat Shock Protein 72 Is Associated with the Hepatitis C Virus Replicase Complex and Enhances Viral RNA Replication

(2010) Yin-Ju Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of heat-shock protein 90 in hepatitis E virus capsid trafficking

(2010) Z.-Z. Zheng et al.   JOURNAL OF GENERAL VIROLOGY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1

(2010) K W Wen et al.   ONCOGENE

Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism

(2010) X. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

(2010) H.D. Gravina et al.   RESEARCH IN VETERINARY SCIENCE

A plastid-targeted heat shock cognate 70kDa protein interacts with the Abutilon mosaic virus movement protein

(2010) Björn Krenz et al.   VIROLOGY

The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production

(2009) Oscar Gonzalez et al.   HEPATOLOGY

Heat-shock Protein 90 Is Essential for Stabilization of the Hepatitis C Virus Nonstructural Protein NS3

(2009) Saneyuki Ujino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cochaperone Activity of Human Butyrate-Induced Transcript 1 Facilitates Hepatitis C Virus Replication through an Hsp90-Dependent Pathway

(2009) S. Taguwa et al.   JOURNAL OF VIROLOGY

hnRNP A1 Interacts with the 5' Untranslated Regions of Enterovirus 71 and Sindbis Virus RNA and Is Required for Viral Replication

(2009) J.-Y. Lin et al.   JOURNAL OF VIROLOGY

A Key Role for Heat Shock Protein 70 in the Localization and Insertion of Tombusvirus Replication Proteins to Intracellular Membranes

(2009) R. Y.-L. Wang et al.   JOURNAL OF VIROLOGY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

The molecular chaperone heat shock protein-90 positively regulates rotavirus infection

(2009) Dipanjan Dutta et al.   VIROLOGY

A temperature sensitive mutant of heat shock protein 70 reveals an essential role during the early steps of tombusvirus replication

(2009) Robert Yung-Liang Wang et al.   VIROLOGY

The Hsp90 molecular chaperone: an open and shut case for treatment

(2008) Laurence H. Pearl et al.   BIOCHEMICAL JOURNAL

(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor†

(2008) Zhengyu Yin et al.   BIOCHEMISTRY

Multitargeted cancer prevention by quercetin

(2008) Akira Murakami et al.   CANCER LETTERS

Heat shock protein inhibitors increase the efficacy of measles virotherapy

(2008) C Liu et al.   GENE THERAPY

Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication

(2008) J.-Y. Lin et al.   JOURNAL OF GENERAL VIROLOGY

A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication

(2008) T. Okamoto et al.   JOURNAL OF VIROLOGY

Nuclear Localization of Cytoplasmic Poly(A)-Binding Protein upon Rotavirus Infection Involves the Interaction of NSP3 with eIF4G and RoXaN

(2008) M. Harb et al.   JOURNAL OF VIROLOGY

Influence of cytoplasmic heat shock protein 70 on viral infection ofNicotiana benthamiana

(2008) ZHAORONG CHEN et al.   MOLECULAR PLANT PATHOLOGY

The co-chaperone BAG3 regulates Herpes Simplex Virus replication

(2008) C. A. Kyratsous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70

(2008) J. Pogany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 inhibitors reduce influenza virus replication in cell culture

(2008) Geoffrey Chase et al.   VIROLOGY

Heat shock 70 protein interaction with Turnip mosaic virus RNA-dependent RNA polymerase within virus-induced membrane vesicles

(2008) Philippe J. Dufresne et al.   VIROLOGY

Heat shock effect upon dengue virus replication into U937 cells

(2008) Salvador Chavez-Salinas et al.   VIRUS RESEARCH

Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb

(2007) Zhuo Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Evaluation of Derrubone and Select Analogues

(2007) Jedidiah M. Hastings et al.   JOURNAL OF ORGANIC CHEMISTRY