ASIC1a mediates the drug resistance of human hepatocellular carcinoma via the Ca2+/PI3-kinase/AKT signaling pathway

Differential effects of calcium on PI3K-Akt and HIF-1α survival pathways

(2016) Georgios Divolis et al.   CELL BIOLOGY AND TOXICOLOGY

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

(2016) Khalid O. Alfarouk   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Preferential extension of short telomeres induced by low extracellular pH

(2016) Yuanlong Ge et al.   NUCLEIC ACIDS RESEARCH

Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo

(2016) Avik Som et al.   Scientific Reports

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

(2016) Ran Wang et al.   Scientific Reports

Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms

(2016) Ming-Gang Liu et al.   Scientific Reports

Ca2+ channel subunit α 1D promotes proliferation and migration of endometrial cancer cells mediated by 17β-estradiol via the G protein-coupled estrogen receptor

(2015) Juan Hao et al.   FASEB JOURNAL

Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

(2015) Yu-Chan Wang et al.   Journal of Neuroinflammation

Regulation of breast tumorigenesis through acid sensors

(2015) S C Gupta et al.   ONCOGENE

Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion

(2015) Cheng Jin et al.   TUMOR BIOLOGY

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

(2015) Xin Tian et al.   Oncotarget

The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface

(2015) Miguel Xavier van Bemmelen et al.   PLoS One

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

Acidic pH derived from cancer cells may induce failed reprogramming of normal differentiated cells adjacent tumor cells and turn them into cancer cells

(2014) Shima Tavakol   MEDICAL HYPOTHESES

Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH

(2014) Erin E. Mendoza et al.   Translational Oncology

Ca2+in quality control

(2013) Daniel A East et al.   Autophagy

Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death

(2013) W.-Z. Zeng et al.   JOURNAL OF NEUROSCIENCE

Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

(2012) Ning Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Activation of Acid-sensing Ion Channel 1a (ASIC1a) by Surface Trafficking

(2010) Sunghee Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LAPTM4B: A novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling

(2010) L Li et al.   ONCOGENE

Knockdown of ASIC1 and Epithelial Sodium Channel Subunits Inhibits Glioblastoma Whole Cell Current and Cell Migration

(2009) Niren Kapoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer

(2009) R. Bao et al.   MOLECULAR CANCER THERAPEUTICS

Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control

(2009) Tian-Le Xu et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells

(2008) Jie Liang et al.   FEBS Journal

The basal level of intracellular calcium gates the activation of phosphoinositide 3-kinase-Akt signaling by brain-derived neurotrophic factor in cortical neurons

(2008) Fei Zheng et al.   JOURNAL OF NEUROCHEMISTRY

 -1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

(2008) Y. Herrera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

(2008) Jennifer S. Fang et al.   SEMINARS IN CANCER BIOLOGY