Review
Endocrinology & Metabolism
Richard L. Cate
Summary: This passage discusses the research on a new hormone related to male sexual development seventy years ago, AMH and AMHR2, and their roles in the regression of the Mullerian duct.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Morozova, Elena Isaeva, Dmitry Klinov
Summary: This study investigated the stability and distribution of protein nanoparticles (NP) in biological fluids and organs after intranasal and oral administration. The results showed that the labeled BSA NP remained stable in blood sera and nasopharyngeal swabs and mainly accumulated in the brain and intestine without inducing innate immunity.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Varshini D. Venkata, M. Fairuz B. Jamaluddin, Jyoti Goad, Hannah R. Drury, Melissa A. Tadros, Rebecca Lim, Ajay Karakoti, Rachel O'Sullivan, Yvette Ius, Kenneth Jaaback, Pravin Nahar, Pradeep S. Tanwar
Summary: This study developed organoids from human fetal reproductive organs and compared them with adult organoids. The results showed that fetal organoids were different from adult organoids in terms of markers expression, appearance, histology, and proteomics. Transplantation of fetal organoids onto adult tissue scaffolds led to regeneration of adult epithelia. Suppression of Wnt signaling inhibited the regenerative ability of fetal organoids and caused anatomical defects in the mouse reproductive tract. Therefore, fetal organoids provide an important platform for studying human female reproductive tract development and diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Stylianos Vagios, Caitlin R. R. Sacha, Kaitlyn E. E. James, Karissa C. C. Hammer, Victoria W. W. Fitz, Irene Dimitriadis, Charles L. L. Bormann, Irene Souter
Summary: This retrospective cohort study aimed to investigate the association between anti-Mullerian hormone (AMH) and pre-ovulatory endometrial thickness (ET) in gonadotropin/intrauterine insemination (IUI) cycles. The results showed a weak correlation between AMH and ET on the day of or the day before hCG ovulation trigger. Furthermore, ET was weakly associated with the odds of clinical pregnancy, except for couples with idiopathic infertility. Therefore, AMH has an impact on endometrial development in gonadotropin-induced cycles, but the association between ET and clinical pregnancy odds is weak.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Plant Sciences
Amara A. Ajaghaku, Daniel L. Ajaghaku, Felix A. Onyegbule, Festus Basden C. Okoye
Summary: This study investigated the estrogenic effect of M. aboensis root extract as a potential alternative for hormone replacement therapy. Phytoestrogen-rich fraction showed potential in increasing uterine weight and protecting liver and kidney against damage induced by ovariectomy. The study suggests the potential use of the plant extract as an alternative to HRT.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Endocrinology & Metabolism
Rachel D. Mullen, Brice Bellessort, Giovanni Levi, Richard R. Behringer
Summary: Dlx5 and Dlx6 are linked transcription factors that play redundant roles in craniofacial, skeletal, and uterine development. They are potentially AMH-induced genes and are involved in mediating AMH-induced regression of the Mullerian duct. Their expression is regulated by AMH signaling, and their absence or mutations can lead to incomplete or severe Mullerian duct regression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cinta Zapater, Ana Rocha, Gregorio Moles, Alessia Mascoli, Soledad Ibanez, Silvia Zanuy, Ana Gomez
Summary: AMH plays a crucial role in teleost gonads, especially in the early stages of germ cell development. The mechanisms involving the interaction of AMH with other growth factors and hormones are not fully understood, but it has been shown to have a significant impact on steroidogenesis in the ovaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Jean-Yves Picard, Gilles Morin, Mojgan Devouassoux-Shisheboran, Jasper Van der Smagt, Serge Klosowski, Catherine Pienkowski, Peggy Pierre-Renoult, Cecile Masson, Christine Bole, Nathalie Josso
Summary: This study found truncation mutations of PPP1R12A in five cases of PMDS, indicating the involvement of myosin phosphatase in Mullerian regression independently of the AMH signaling cascade. The congenital abnormalities associated with PPP1R12A mutations are consistent with previous literature and differ from cases of AMH or AMHR2 mutations. The lack of experimental validation is a limitation of the study.
HUMAN REPRODUCTION
(2022)
Review
Oncology
Malar Raj Philips, Arun Ramdas Menon, Kanuj Malik, Sruti Chandrasekaran, Thendral Ramaswamy, Kathiresan Narayanaswamy, Anand Raja
Summary: Persistent Mullerian duct syndrome (PMDS) is a rare disorder causing fetal Mullerian duct regression failure, often associated with undescended testis and increased risk of testicular tumors. This study presents institutional experience and literature review on testicular cancer in PMDS.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Linda F. Boeswald, Dana Matzek, Helen Mohr, Ellen Kienzle, Bastian Popper
Summary: Body conditions can serve as indicators of nutritional status and health in animals, highlighting the importance of monitoring these conditions. Obtaining morphometric data through measurements and standardized photographs can be useful for evaluating the body condition and well-being of animals.
Review
Biochemistry & Molecular Biology
Kang An, Baohui Yao, Yuchen Tan, Yukun Kang, Junhu Su
Summary: Seasonal reproduction is an important survival strategy for animals to adapt to environmental changes. Recent research suggests that the hormone AMH may play a role in regulating reproductive activities during the non-breeding period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Olatz Goni-Balentziaga, Sergi Vila, Ivan Ortega-Saez, Oscar Vegas, Garikoitz Azkona
Summary: Animal-facility personnel scored higher in work-related quality of life and compassion satisfaction compared to researchers, with perceived animal stress/pain, human-animal interaction, and social support being factors influencing professional quality of life. Job category is a key contributing factor in perceived professional quality of life.
Article
Andrology
Ravinder Kaur, Arshpreet Kaur, Sanya Vermani
Summary: Early detection and management of disorders of sexual development require a coordinated approach involving a team of endocrinologist, physician, surgeon, and radiologist. Integrated imaging plays a crucial role in demonstrating anatomy, classification, risk warnings, and surgical planning.
Article
Emergency Medicine
Seth Ball, Jay Fisher
Summary: Abdominal pain is a common complaint in the Emergency Department, and one rare cause is obstructed hemivagina and ipsilateral renal anomaly. This article presents a case of a 12-year-old girl with didelphys uterus and obstructed hemivagina. OHVIRA is a triad of developmental arrest involving the mullerian and mesonephric ducts.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dulce Lima Cunha, Amanda Oram, Robert Gruber, Roswitha Plank, Arno Lingenhel, Manoj K. Gupta, Janine Altmuller, Peter Nurnberg, Matthias Schmuth, Johannes Zschocke, Tomo Saric, Katja M. Eckl, Hans C. Hennies
Summary: The article introduces the successful generation of in vitro models mimicking the disease phenotypes of inherited ichthyoses using patient-derived human induced pluripotent stem cells (hiPSCs), which can be used for further molecular investigations and drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lilian M. Demberg, Jana Winkler, Caroline Wilde, Kay-Uwe Simon, Julia Schoen, Sven Rothemund, Torsten Schoeneberg, Simone Proemel, Ines Liebscher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Cell Biology
Claudia Merkwitz, Orest Blaschuk, Jana Winkler, Angela Schulz, Simone Proemel, Albert Markus Ricken
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2017)
Article
Biology
Nicole Scholz, Chonglin Guan, Matthias Nieberler, Alexander Grotemeyer, Isabella Maiellaro, Shiqiang Gao, Sebastian Beck, Matthias Pawlak, Markus Sauer, Esther Asan, Sven Rothemund, Jana Winkler, Simone Proemel, Georg Nagel, Tobias Langenhan, Robert J. Kittel
Article
Cell Biology
Juliane Roethe, Doreen Thor, Jana Winkler, Alexander B. Knierim, Claudia Binder, Sandra Huth, Robert Kraft, Sven Rothemund, Torsten Schoeneberg, Simone Proemel
Review
Neurosciences
Torsten Schoeneberg, Simone Proemel
FRONTIERS IN NEUROSCIENCE
(2019)
Editorial Material
Multidisciplinary Sciences
Rory K. Morgan, Garret R. Anderson, Demet Arac, Gabriela Aust, Nariman Balenga, Antony Boucard, James P. Bridges, Felix B. Engel, Caroline J. Formstone, Maike D. Glitsch, Ryan S. Gray, Randy A. Hall, Cheng-Chih Hsiao, Hee-Yong Kim, Alexander B. Knierim, Deva Krupakar Kusuluri, Katherine Leon, Ines Liebscher, Xianhua Piao, Simone Proemel, Nicole Scholz, Swati Srivastava, Doreen Thor, Kimberley F. Tolias, Yuri A. Ushkaryov, Mario Vallon, Erwin G. Van Meir, Benoit Vanhollebeke, Uwe Wolfrum, Kevin M. Wright, Kelly R. Monk, Amit Mogha
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Biochemical Research Methods
Ruud Heshof, Bram Visscher, Simone Proemel, Samantha Hughes
Article
Cell Biology
Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Gross, Anette Kaiser, Simone Proemel
CELL COMMUNICATION AND SIGNALING
(2019)
Review
Biochemistry & Molecular Biology
Isabell Kaczmarek, Tomas Suchy, Simone Proemel, Torsten Schoeneberg, Ines Liebscher, Doreen Thor
Summary: Adhesion GPCRs (aGPCRs) are a unique class of orphan receptors with potential therapeutic targets. They can couple with G proteins and potentially expand the ways of influencing physiological functions. Besides their significance in the immune and central nervous systems, aGPCRs also play important roles in metabolic tissues.
BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Matus, Willem Berend Post, Susanne Horn, Torsten Schoeneberg, Simone Proemel
Summary: It has been shown that Latrophilin-1 has a trans function in the Caenorhabditis elegans nervous system, mediating the morphogenesis of sensory structures and playing a physiological role in copulation behavior. Detailed analysis revealed specific LAT-1-positive neurons and the genetic network modulated by the receptor function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ines Liebscher, Orkun Cevheroglu, Cheng-Chih Hsiao, Andre F. Maia, Hannes Schihada, Nicole Scholz, Mark Soave, Katja Spiess, Katarina Trajkovic, Mickey Kosloff, Simone Proemel
Summary: Adhesion G protein-coupled receptors (aGPCRs) are intriguing cell surface receptors with essential functions in health and disease, holding vast pharmacological potential. Understanding their physiology and signaling mechanisms forms the basis for further molecular exploration, while combining new tools and methodologies from different fields can push aGPCR research towards a more comprehensive knowledge for practical applications.
Article
Biochemistry & Molecular Biology
Aline Wittlake, Simone Proemel, Torsten Schoeneberg
Summary: The study provides new insights into the classification and evolutionary relationships of aGPCRs in vertebrates, indicating the appearance of new family members after the fish-tetrapod split. Through ortholog sequence alignments, different selection pressures were identified on aGPCR families during tetrapod evolution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Victoria Elisabeth Gross, Miron Mikhailowitsch Gershkovich, Torsten Schoeneberg, Anette Kaiser, Simone Proemel
Summary: The study demonstrates the use of in vivo NanoBRET as a powerful tool to investigate protein interactions and localization in a physiological setting in the living organism C. elegans.
BMC MOLECULAR AND CELL BIOLOGY
(2022)
Review
Developmental Biology
Daniel Matus, Simone Proemel
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Olha Nazarko, Amanuel Kibrom, Jana Winkler, Katherine Leon, Hannah Stoveken, Gabriel Salzman, Katarzyna Merdas, Yue Lu, Pradnya Narkhede, Gregory Tall, Simone Proemel, Demet Arac