Treponema denticola Has the Potential to Cause Neurodegeneration in the Midbrain via the Periodontal Route of Infection—Narrative Review

Locus Coeruleus Dysfunction and Trigeminal Mesencephalic Nucleus Degeneration: A Cue for Periodontal Infection Mediated Damage in Alzheimer’s Disease?

(2023) Flavio Pisani et al.   International Journal of Environmental Research and Public Health

Tooth Loss Suppresses Hippocampal Neurogenesis and Leads to Cognitive Dysfunction in Juvenile Sprague–Dawley Rats

(2022) Jiangqi Hu et al.   Frontiers in Neuroscience

Mental health and periodontal and peri‐implant diseases

(2022) Jake Ball et al.   PERIODONTOLOGY 2000

The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology

(2022) Flavio Pisani et al.   International Journal of Environmental Research and Public Health

The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice

(2021) Ashis Dhar et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

A Novel Approach to the Treatment and Prevention of Alzheimer’s Disease Based on the Pathology and Microbiology

(2021) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Treponema pallidum Macrolide Resistance and Molecular Epidemiology in Southern Africa, 2008 to 2018

(2021) Johanna M. E. Venter et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Association between Tooth Loss and Alzheimer’s Disease in a Nested Case–Control Study Based on a National Health Screening Cohort

(2021) Ji Hee Kim et al.   Journal of Clinical Medicine

The emerging role of complement in neuromuscular disorders

(2021) John D. Lee et al.   Seminars in Immunopathology

Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Data from the Zabút Aging Project

(2020) Vera Panzarella et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer’s Disease in 3×Tg-AD Model Mice

(2020) Tetsuya Goto et al.   JOURNAL OF ALZHEIMERS DISEASE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Periodontitis to dementia or converse?

(2019) A. Harding et al.   BRITISH DENTAL JOURNAL

Microglia in Brain Development, Homeostasis, and Neurodegeneration

(2019) Christopher J. Bohlen et al.   Annual Review of Genetics

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis

(2019) Hong Min Ng et al.   Frontiers in Cellular and Infection Microbiology

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Progress in and promise of bacterial quorum sensing research

(2017) Marvin Whiteley et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Neuroanatomy of the Reticular Nucleus Locus Coeruleus in Alzheimer’s Disease

(2017) Filippo S. Giorgi et al.   Frontiers in Neuroanatomy

Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition

(2017) Alice Harding et al.   Frontiers in Aging Neuroscience

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

(2017) Chris J. Carter et al.   Frontiers in Aging Neuroscience

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

(2016) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E Related Co-Morbidities and Alzheimer’s Disease

(2016) Sim K. Singhrao et al.   JOURNAL OF ALZHEIMERS DISEASE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors

(2013) Stefka Gyoneva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaeteTreponema denticola

(2013) Kurni Kurniyati et al.   MOLECULAR MICROBIOLOGY

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Structure of Factor H-binding Protein B (FhbB) of the Periopathogen,Treponema denticola

(2012) Daniel P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chewing Ability and Tooth Loss: Association with Cognitive Impairment in an Elderly Population Study

(2012) Duangjai Lexomboon et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

New insights into the emerging role of oral spirochaetes in periodontal disease

(2011) M.B. Visser et al.   CLINICAL MICROBIOLOGY AND INFECTION

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Treponema denticola Major Outer Sheath Protein Induces Actin Assembly at Free Barbed Ends by a PIP2-Dependent Uncapping Mechanism in Fibroblasts

(2011) Michelle B. Visser et al.   PLoS One

Virulence Factors of the Oral Spirochete Treponema denticola

(2010) S.G. Dashper et al.   JOURNAL OF DENTAL RESEARCH

Mastication for the mind—The relationship between mastication and cognition in ageing and dementia

(2010) R.A.F. Weijenberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Oral Biofilm Architecture on Natural Teeth

(2010) Vincent Zijnge et al.   PLoS One

Mitochondrial trafficking and morphology in neuronal injury

(2009) Gordon L. Rintoul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

The cofilin activity cycle in lamellipodia and invadopodia

(2009) Matthew Oser et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The microbiology of the acute dental abscess

(2009) D. Robertson et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Treponema denticola biofilm-induced expression of a bacteriophage, toxin-antitoxin systems and transposases

(2009) H. L. Mitchell et al.   MICROBIOLOGY-SGM

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans

(2009) O. I. Wagner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression of chronic periodontitis can be predicted by the levels ofPorphyromonas gingivalisandTreponema denticolain subgingival plaque

(2009) S. J. Byrne et al.   Oral microbiology and immunology

Bacterial Quorum Sensing: Signals, Circuits, and Implications for Biofilms and Disease

(2008) Arul Jayaraman et al.   Annual Review of Biomedical Engineering

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

(2008) Hirokazu Fukui et al.   HUMAN MOLECULAR GENETICS

Toxin-Antitoxin Systems in Escherichia coli Influence Biofilm Formation through YjgK (TabA) and Fimbriae

(2008) Y. Kim et al.   JOURNAL OF BACTERIOLOGY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Factor H family proteins and human diseases

(2008) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY