Article
Oncology
Hechen Wang, Tianyu Wang, Zeying Zhang, Yu Fan, Lan Zhang, Kuan Gao, Shuya Luo, Qinghuan Xiao, Changfu Sun
Summary: High TMEM16A expression is associated with large tumor size, lymph node metastasis, and poor clinical outcome in patients with OSCC. TMEM16A overexpression promotes cell proliferation, while inhibition of TMEM16A channel activities suppresses cell proliferation in OSCC cells. Simvastatin suppresses TMEM16A channel activities and inhibits cell proliferation in OSCC cells through TMEM16A, providing a novel anti-tumor mechanism.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Physiology
Beth A. McNally, Amber E. Plante, Andrea L. Meredith
Summary: Daily regulation of BK channel activity in the suprachiasmatic nucleus (SCN) is dependent on the type of Ca2+ channels, with LTCCs playing a major role during the day and less so at night. SCN neurons lack a specific subtype of Ca2+ channels responsible for BK current activation, suggesting a complex interplay between different LTCC subtypes.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hiroaki Kito, Susumu Ohya
Summary: Osteoblasts are crucial in bone modeling and remodeling, with their differentiation being regulated by various signaling pathways. Proper bone homeostasis depends on the differentiation and function of osteoblast lineage cells. Ca2+ signaling controls many processes in osteoblast lineage cells, and K+ channel activation indirectly influences Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart
Summary: Ondansetron inhibits hSK2 currents even under altered ionic conditions, potentially showing antiarrhythmic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Xiaoling Jia, Qingmao Yang, Chao Gao, Xinlan Chen, Yanan Li, Hao Su, Yufan Zheng, Shuwen Zhang, Ziyu Wang, Haikun Wang, Lin-Hua Jiang, Yan Sun, Yubo Fan
Summary: This study demonstrates that on substrates with pathologically relevant stiffness, the upregulation of the IKCa channel enhances intracellular Ca2+ signaling and activates the ERK signal pathway to promote VSMC proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Taro Koya, Masaya Watanabe, Hiroyuki Natsui, Takahide Kadosaka, Takuya Koizumi, Motoki Nakao, Hikaru Hagiwara, Rui Kamada, Taro Temma, Toshihisa Anzai
Summary: This study found that inhibiting nNOS can increase the inducibility of atrial arrhythmia, and a specific SK channel blocker called apamin can reverse the increased inducibility of arrhythmia. Apamin can mitigate the abbreviation of APD without altering Ca2+ transient, suggesting an underlying mechanism of posttranslational modification of SK channels.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cell Biology
Antonio Michelucci, Luigi Sforna, Angela Di Battista, Fabio Franciolini, Luigi Catacuzzeno
Summary: Glioblastoma (GBM) is a deadly brain tumor that invades healthy brain tissue through cell migration and invasion. The precise nature of the K+ channels involved in cell volume regulation in this type of tumor has remained uncertain. This study found that hypotonic-induced cell swelling in GBM U87-MG cells triggers the opening of calcium-activated K+ channels, particularly BKCa and IKCa, which play a key role in the regulatory volume decrease following hypotonic shock.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ning-Ping Foo, Yu-Fan Liu, Ping-Ching Wu, Chung-Hsi Hsing, Bu-Miin Huang, Edmund-Cheung So
Summary: This study found that MDZ suppressed the current density of I-K(DR) in a concentration-, time-, and state-dependent manner in Jurkat T-lymphocytes, and affected immune-regulating cytokine expression in LPS/PMA-treated human T lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maurish Bukhari, Han Deng, Darren Sipes, Marisa Ruane-Foster, Kayla Purdy, Craig D. Woodworth, Shantanu Sur, Damien S. K. Samways
Summary: This study reveals that elevated cytosolic Ca2+ levels stimulate rapid uptake and nuclear accumulation of a DNA-binding fluorescent dye in cervical cancer cells, dependent on activation of intermediate conductance Ca2+-activated K+ channels. Comparisons between cancerous and healthy cervical epithelial cells show significant differences in functional K+ channel activity, which correlates with the incidence of dye uptake. Activation of these channels sensitizes cancer cells to growth suppressant effects, suggesting potential use of channel activators to enhance penetration of toxins into cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Peripheral Vascular Disease
Yuan Sun, Cuicui Wang, Na Zhang, Fang Liu
Summary: Melatonin supplementation ameliorates hypertension in pregnant mice with gestational hypertension and enhances uterine artery endothelial response to acetylcholine. The BKCa potassium channel is involved in this effect of melatonin on uterine artery endothelial function, promoting its expression and function. Ultimately, melatonin improves pregnancy outcomes in pregnant mice.
HYPERTENSION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tianyu Wang, Hui Wang, Fan Yang, Kuan Gao, Shuya Luo, Lichuan Bai, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Zaixing Chen, Qinghuan Xiao
Summary: This study revealed a new anticancer mechanism of honokiol by inhibiting cell proliferation through targeting Ano1 Ca2+-activated Cl- channels. Honokiol more potently inhibited Ano1 currents compared to Ano2 currents, with three critical amino acids (R429, K430, and N435) identified for honokiol-induced Ano1 inhibition.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jinhong Wie, Zhenjiang Liu, Haikun Song, Thomas F. Tropea, Lu Yang, Huanhuan Wang, Yuling Liang, Chunlei Cang, Kimberly Aranda, Joey Lohmann, Jing Yang, Boxun Lu, Alice S. Chen-Plotkin, Kelvin C. Luk, Dejian Ren
Summary: This study uncovers a pathway by which extracellular growth factors regulate intracellular organelle function, and establishes a targetable mechanism by which common variants of TMEM175 confer risk for Parkinson's disease. The TMEM175 gene's common variants can increase or decrease the risk of developing Parkinson's disease, affecting neuronal damage and defense capabilities.
Article
Cell Biology
Xiaolin Xu, Xianli Wu, Gengyu Yue, Qimin An, Jun Lou, Xiaoxu Yang, Zhe Jin, Jianhong Ding, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
Summary: This article summarizes the activation mechanisms of inflammasomes and their relationship with diseases, and provides an overview of the effects of intracellular and extracellular ion activities and ion channels on inflammasome activation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dmitrii Kolesnikov, Anastasiia Perevoznikova, Konstantin Gusev, Lyubov Glushankova, Elena Kaznacheyeva, Alexey Shalygin
Summary: Local calcium entry through TRPC1 channels activates endogenous calcium-activated chloride channels (CaCCs), suggesting their involvement in calcium entry microdomains. The properties of CaCCs are influenced by transmembrane potential and calcium concentration, with close local arrangement of functional CaCCs and TRPC1 channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Saranya NavaneethaKrishnan, Vincent Law, Jungkwon Lee, Jesusa L. Rosales, Ki-Young Lee
Summary: Loss of Cdk5 causes an increase in cytosolic calcium concentration, promoting cell proliferation and increased body weight in embryos. Cdk5 interacts with IP3R1 and regulates IP3R1-mediated calcium release through phosphorylation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hae Jin Kim, Ming Zhe Yin, Suhan Cho, Sung Eun Kim, Seong Woo Choi, Sang Kyu Ye, Hae Young Yoo, Sung Joon Kim
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Article
Education, Scientific Disciplines
Young Keul Jeon, Jae Boum Youm, Kotdaji Ha, JooHan Woo, Hae Young Yoo, Chae Hun Leem, Seung Hee Lee, Sung Joon Kim
ADVANCES IN PHYSIOLOGY EDUCATION
(2020)
Article
Biochemistry & Molecular Biology
Young Keul Jeon, Si Won Choi, Jae Won Kwon, Joohan Woo, Seong Woo Choi, Sang Jeong Kim, Sung Joon Kim
Summary: The study demonstrates that physiological temperature significantly enhances the activation of calhm1 current, resulting in increased amplitude, accelerated speed, and lower half-activation voltage. This finding is crucial for understanding the electrophysiology of brain and taste cells with high expression of calhm1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Jae Hoon Moon, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Jeong Hun Hah, Yul Hwangbo, Woo-Jin Jeong, Yuh-Seog Jung, Ji-Hoon Kim, Min Joo Kim, Su-Jin Kim, Yeo Koon Kim, Chang Yoon Lee, Eun Kyung Lee, Ji Ye Lee, Kyu Eun Lee, You Jin Lee, Yumi Lee, Hyeong Won Yu, Do Joon Park, Junsun Ryu, Young Joo Park
Summary: The study found that for patients with low-risk PTMC, choosing active surveillance may have a positive impact on quality of life over a 2-year period.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Physiology
Si Won Choi, Joohan Woo, Kyung Sun Park, Juyeon Ko, Young Keul Jeon, Seong Woo Choi, Hae Young Yoo, Inseong Kho, Tae Jin Kim, Sung Joon Kim
Summary: In this study, the expression and activity of K2P channels in different subsets of mouse B cells were compared, showing a functional upregulation of TREK-2 and increased Ca2+ influx in B1a cells upon Toll-like receptor 4 stimulation.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Physiology
Hae Young Yoo, Sung Joon Kim
Summary: Oxygen is crucial for cell survival in aerobic organisms, and lack of oxygen leads to hypoxia. Neural control mechanisms ensure adequate oxygen distribution to cells and tissues. Research on the modulation of oxygen distribution systems and the sensing mechanisms of oxygen levels is of great interest.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seong-Woo Choi, Ming-Zhe Yin, Na-Kyeong Park, Joo-Han Woo, Sung-Joon Kim
Summary: 4-ONE modulates cardiac ion channels, especially hNa(V)1.5, increasing the risk of arrhythmia.
Article
Hematology
Jung-Min Park, Van Quan Do, Yoon-Seok Seo, Hyun Jong Kim, Joo Hyun Nam, Ming Zhe Yin, Hae Jin Kim, Sung Joon Kim, Kathy K. Griendling, Moo-Yeol Lee
Summary: This study reveals that NOX1 mediates the generation of Ca2+ signals and contributes to vascular contraction and blood pressure elevation induced by Ang II.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Environmental Sciences
Young Ju Jin, Jeong Hun Hah, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Sung-Kyun Kim, Bumjung Park, Hyo Geun Choi
Summary: This study evaluated the differences in body mass index (BMI) and blood pressure between Korean adults who underwent thyroidectomy and a comparison group. The results showed that diastolic blood pressure was significantly lower after thyroidectomy in both thyroid cancer patients and the comparison group. However, the overall BMI, systolic blood pressure, and diastolic blood pressure did not show significant differences between the thyroidectomy group and the matched comparison group.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Yul Hwangbo, June Young Choi, Eun Kyung Lee, Chang Hwan Ryu, Sun Wook Cho, Eun-Jae Chung, Jeong Hun Hah, Woo-Jin Jeong, Sue K. Park, Yuh-Seog Jung, Ji-Hoon Kim, Min Joo Kim, Su-Jin Kim, Yeo Koon Kim, Chang Yoon Lee, Ji Ye Lee, You Jin Lee, Hyeong Won Yu, Do Joon Park, Junsun Ryu, Young Joo Park, Kyu Eun Lee, Jae Hoon Moon
Summary: The study identified factors associated with the choice of active surveillance (AS) for patients with low-risk papillary thyroid microcarcinoma (PTMC) including patient age, tumor size, consultation with an endocrinologist, and use of a decision aid. Patients in the AS group were more influenced by information from the media, while those in the immediate surgery (iOP) group were more influenced by family members.
Article
Otorhinolaryngology
Doh Young Lee, J. Hun Hah, Woo-Jin Jeong, Eun-Jae Chung, Tack-Kyun Kwon, Soon-Hyun Ahn, Myung-Whun Sung, Seong Keun Kwon
Summary: This study aimed to assess the genetic differences between cases of early-stage tongue cancer that were positive or negative for lymph node metastasis. It was found that defensin may be a novel biomarker for early regional metastasis in T1/2 tongue cancer.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2022)
Article
Cell Biology
Jae Won Kwon, Young Keul Jeon, Sung Joon Kim
Summary: This study investigates the effects of extracellular and intracellular pH on human CALHM1 and reveals the remarkable pH sensitivity of CALHM1, which might contribute to the pH-dependent modulation of neuronal excitability or taste sensation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae Won Kwon, Young Keul Jeon, Jinsung Kim, Sang Jeong Kim, Sung Joon Kim
Summary: The study found that specific cysteine residues in the CALHM1 channel are crucial for protein biogenesis and ionic current, with disruption of these residues affecting protein expression on the membrane. Furthermore, it was highlighted that extracellular disulfide bonds play a significant role in folding, oligomerization, and trafficking of CALHM1, while being dispensable for voltage-dependent activation once on the plasma membrane.
MOLECULES AND CELLS
(2021)
Article
Medicine, Research & Experimental
Young Ah Lee, Hyunjung Lee, Sun-Wha Im, Young Shin Song, Do-Youn Oh, Hyoung Jin Kang, Jae-Kyung Won, Kyeong Cheon Jung, Dohee Kwon, Eun-Jae Chung, J. Hun Hah, Jin Chul Paeng, Ji-hoon Kim, Jaeyong Choi, Ok-Hee Kim, Ji Min Oh, Byeong-Cheol Ahn, Lori J. Wirth, Choong Ho Shin, Jong-Il Kim, Young Joo Park
Summary: This study investigated the molecular characteristics of pediatric papillary thyroid cancer (PTC) and identified different genetic drivers, including fusion oncogenes and point mutations. For patients with fusion oncogene PTC, fusion-directed therapy may lead to dramatic tumor responses.
JOURNAL OF CLINICAL INVESTIGATION
(2021)