Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 534, Issue -, Pages 590-596Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.11.035
Keywords
Calcium homeostasis modulator 1 (calhm1); Thermosensitivity; Voltage-dependent activation
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Funding
- National Research Foundation of Korea [NRF-2018R1A5A2025964]
- Seoul National University Hospital
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The study demonstrates that physiological temperature significantly enhances the activation of calhm1 current, resulting in increased amplitude, accelerated speed, and lower half-activation voltage. This finding is crucial for understanding the electrophysiology of brain and taste cells with high expression of calhm1.
Calcium homeostasis modulator 1 (calhm1) proteins form an outwardly rectifying nonselective ion channel having exceedingly slow kinetics and low sensitivity to voltage that is shifted by lowering extracellular Ca2+ ([Ca2+](e)). Here we found that physiological temperature dramatically facilitates the voltage-dependent activation of the calhm1 current (I-calhm1); increased amplitude (Q(10), 7-15) and fastened speed of activation. Also, the leftward shift of the half-activation voltage (V-1/2) was similary observed in the normal and lower [Ca2+](e). Since calhm1 is highly expressed in the brain and taste cells, the thermosensitivity should be considered in their electrophysiology. (C) 2020 Elsevier Inc. All rights reserved.
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