Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Isolation and Synthetic Diversification of Jadomycin 4-Amino-l-phenylalanine

(2015) Camilo F. Martinez-Farina et al.   JOURNAL OF NATURAL PRODUCTS

Myxochelins Target Human 5-Lipoxygenase

(2015) Sebastian Schieferdecker et al.   JOURNAL OF NATURAL PRODUCTS

The arachidonic acid–LTB4–BLT2 pathway enhances human B-CLL aggressiveness

(2014) Nathalie Guriec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell-like Cells in Acute Myeloid Leukemia

(2014) J. Roos et al.   CANCER RESEARCH

Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory BacteriumPyxidicoccus fallax

(2014) Sebastian Schieferdecker et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibiotics from myxobacteria

(2014) Till F. Schäberle et al.   NATURAL PRODUCT REPORTS

Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae

(2013) Martin F. Kreutzer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling

(2013) Weerawat Runguphan et al.   ORGANIC LETTERS

The generation of “unNatural” products: Synthetic biology meets synthetic chemistry

(2012) Rebecca J. M. Goss et al.   NATURAL PRODUCT REPORTS

Jadomycins Derived from the Assimilation and Incorporation of Norvaline and Norleucine

(2011) Stephanie N. Dupuis et al.   JOURNAL OF NATURAL PRODUCTS

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myxobacteria, Polarity, and Multicellular Morphogenesis

(2010) D. Kaiser et al.   Cold Spring Harbor Perspectives in Biology

Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites

(2009) Silke C. Wenzel et al.   Molecular BioSystems

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

(2008) Sabine Grüschow et al.   CHEMBIOCHEM

Myxochelin Biosynthesis: Direct Evidence for Two- and Four-Electron Reduction of a Carrier Protein-Bound Thioester

(2008) Yanyan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY