Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target

(2022) Nourhan Abdelfattah et al.   Nature Communications

Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

(2022) Wenjing Xuan et al.   Cancer Immunology Research

Cancer Stemness Meets Immunity: From Mechanism to Therapy

(2021) Peiwen Chen et al.   Cell Reports

Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms

(2021) Wenjing Xuan et al.   TRENDS IN IMMUNOLOGY

Circadian regulation of cancer cell and tumor microenvironment crosstalk

(2021) Wenjing Xuan et al.   TRENDS IN CELL BIOLOGY

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

(2020) Peiwen Chen et al.   Cancer Discovery

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells

(2020) Rocco Lucero et al.   Cell Reports

The Glioma Stem Cell Model in the Era of Single-Cell Genomics

(2020) Mario L. Suvà et al.   CANCER CELL

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

(2020) Patrick Y Wen et al.   NEURO-ONCOLOGY

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

(2020) Nicole D. Barth et al.   Nature Communications

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

Progression-Free but No Overall Survival Benefit for Adult Patients with Bevacizumab Therapy for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis

(2019) Nagham Kaka et al.   Cancers

Periostin Limits Tumor Response to VEGFA Inhibition

(2018) Ioanna Keklikoglou et al.   Cell Reports

Myeloid TBK1 Signaling Contributes to the Immune Response to Influenza

(2018) Robert S Hagan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer

(2017) Yaping Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

(2017) Banu Eskiocak et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

(2017) Victoria H. Cruz et al.   Journal of Cell Communication and Signaling

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models

(2016) S. Y. Park et al.   MOLECULAR CANCER THERAPEUTICS

Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation

(2016) Takashi Shingu et al.   NATURE GENETICS

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies

(2016) Maroof Hasan et al.   PHARMACOLOGICAL RESEARCH

Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling

(2016) Yang Liu et al.   Oncotarget

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments

(2014) Allan Yi Liu et al.   MATRIX BIOLOGY

VEGF-targeted cancer therapeutics—paradoxical effects in endocrine organs

(2014) Yihai Cao   Nature Reviews Endocrinology

IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples

(2014) Frency Varghese et al.   PLoS One

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

(2013) Massimo Masiero et al.   CANCER CELL

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124

(2013) Aihua Li et al.   FEBS LETTERS

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3

(2012) Abdessamad Zerrouqi et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

(2012) Lasse Dahl Jensen et al.   Cell Reports

Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner

(2011) P. Chen et al.   CLINICAL CANCER RESEARCH

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Forty-Year Journey of Angiogenesis Translational Research

(2011) Y. Cao et al.   Science Translational Medicine

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Off-tumor target—beneficial site for antiangiogenic cancer therapy?

(2010) Yihai Cao   Nature Reviews Clinical Oncology

Tumor angiogenesis and molecular targets for therapy

(2009) Yihai Cao   Frontiers in Bioscience-Landmark

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of TBK-1 on tumor angiogenesis and microvascular inflammation

(2008) Marcus Czabanka   Frontiers in Bioscience-Landmark

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE