Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane

Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity

(2014) Sara Fahs et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immuno-oncology Combinations: A Review of Clinical Experience and Future Prospects

(2014) S. J. Antonia et al.   CLINICAL CANCER RESEARCH

Targeting the BH3 Domain of Bcl-2 Family Proteins. A Brief History From Natural Products to Foldamers As Promising Cancer Therapeutic Avenues

(2013) M. De Giorgi et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

(2013) S. Kushal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-Negative Activity

(2013) Hitesh D. Thaker et al.   ACS Medicinal Chemistry Letters

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival

(2012) Nicole A. Cohen et al.   CHEMISTRY & BIOLOGY

Update of Peptides with Antibacterial Activity

(2012) X. Vila-Farres et al.   CURRENT MEDICINAL CHEMISTRY

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors

(2012) Jeremy L. Yap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors

(2012) Chao-Yie Yang et al.   ACS Medicinal Chemistry Letters

Helix-mediated protein–protein interactions as targets for intervention using foldamers

(2011) Thomas A. Edwards et al.   AMINO ACIDS

Apoptotic cell signaling in cancer progression and therapy

(2011) Jessica Plati et al.   Integrative Biology

Oligophenylenaminones as Scaffolds for α-Helix Mimicry

(2011) Marc J. Adler et al.   JOURNAL OF ORGANIC CHEMISTRY

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

(2011) Melissa D. Boersma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the selectivity and efficacy of defense peptides with respect to cancer cells

(2011) Frederick Harris et al.   MEDICINAL RESEARCH REVIEWS

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Design and synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein–protein interactions disruptors

(2011) Marcella De Giorgi et al.   TETRAHEDRON

Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

(2010) Andrea L. Jochim et al.   ACS Chemical Biology

Protein-protein interactions in transcription: A fertile ground for helix mimetics

(2010) Danielle A. Guarracino et al.   BIOPOLYMERS

High Specificity in Protein Recognition by Hydrogen-Bond-Surrogate α-Helices: Selective Inhibition of the p53/MDM2 Complex

(2010) Laura K. Henchey et al.   CHEMBIOCHEM

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches

(2010) Riadh Hammami et al.   DRUG DISCOVERY TODAY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

(2010) Y. Zhang et al.   NUCLEIC ACIDS RESEARCH

N-alkylated oligoamide α-helical proteomimetics

(2010) Frederick Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of new phenylpyridyl scaffolds using the Garlanding approach

(2010) Anne Sophie Voisin-Chiret et al.   TETRAHEDRON

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

(2009) Sara J. Buhrlage et al.   ACS Chemical Biology

Antifungal and antitumor models of bioactive protective peptides

(2009) Elaine G. Rodrigues et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

β-Peptides with improved affinity for hDM2 and hDMX

(2009) Elizabeth A. Harker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The global burden of cancer: priorities for prevention

(2009) M. J. Thun et al.   CARCINOGENESIS

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

Recent advances in the development of aryl-based foldamers

(2009) Ishu Saraogi et al.   CHEMICAL SOCIETY REVIEWS

Medicinal Chemistry of Paclitaxel and its Analogues

(2009) Y. Fu et al.   CURRENT MEDICINAL CHEMISTRY

Cationic amphiphilic peptides with cancer-selective toxicity

(2009) Frank Schweizer   EUROPEAN JOURNAL OF PHARMACOLOGY

New strategies for novel antibiotics: peptides targeting bacterial cell membranes

(2009) K. Lohner   GENERAL PHYSIOLOGY AND BIOPHYSICS

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessment of helical interfaces in protein–protein interactions

(2009) Andrea L. Jochim et al.   Molecular BioSystems

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold

(2009) Srinivasa Marimganti et al.   ORGANIC LETTERS

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

(2008) Sharmila Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Indolocarbazole-Based Foldamers Capable of Binding Halides in Water

(2008) Jae-min Suk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

(2008) Alan A Arnold et al.   Molecular Cancer

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting tumors with peptides from natural sources

(2008) Sujit K. Bhutia et al.   TRENDS IN BIOTECHNOLOGY

Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells

(2008) Henrik Suttmann et al.   BMC Urology

Studies on anticancer activities of antimicrobial peptides

(2007) David W. Hoskin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers

(2007) Gregory J. Gabriel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY