Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements

Analysis of Factors Affecting 5-ALA Fluorescence Intensity in Visualizing Glial Tumor Cells—Literature Review

(2022) Marek Mazurek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near‐infrared window

(2022) Jonathan Shapey et al.   Journal of Biophotonics

5-Aminolevulinic Acid-Induced Porphyrin Contents in Various Brain Tumors: Implications Regarding Imaging Device Design and Their Validation

(2021) Eric Suero Molina et al.   NEUROSURGERY

Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery

(2021) David Black et al.   Scientific Reports

Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study

(2020) Eric Suero Molina et al.   ACTA NEUROCHIRURGICA

Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas

(2020) Sadahiro Kaneko et al.   ACTA NEUROCHIRURGICA

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

(2019) Pablo A. Valdes et al.   JOURNAL OF NEURO-ONCOLOGY

The value of visible 5-ALA fluorescence and quantitative protoporphyrin IX analysis for improved surgery of suspected low-grade gliomas

(2019) Georg Widhalm et al.   JOURNAL OF NEUROSURGERY

Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas

(2019) Sadahiro Kaneko et al.   NEUROSURGERY

Intraoperative fluorescence diagnosis in the brain: a systematic review and suggestions for future standards on reporting diagnostic accuracy and clinical utility

(2019) Walter Stummer et al.   ACTA NEUROCHIRURGICA

Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors

(2019) Michael Schwake et al.   ACTA NEUROCHIRURGICA

In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?

(2019) Kym McNicholas et al.   BRITISH JOURNAL OF CANCER

Determination of optical properties of human brain tumor tissues from 350 to 1000 nm to investigate the cause of false negatives in fluorescence-guided resection with 5-aminolevulinic acid

(2018) Norihiro Honda et al.   JOURNAL OF BIOMEDICAL OPTICS

Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection

(2018) David W. Roberts et al.   JOURNAL OF NEUROSURGERY

5-ALA in the management of malignant glioma

(2018) Herbert Stepp et al.   LASERS IN SURGERY AND MEDICINE

NADH Autofluorescence-A Marker on its Way to Boost Bioenergetic Research

(2018) Patrick M. Schaefer et al.   CYTOMETRY PART A

Nonlinear relation between concentration and fluorescence emission of protoporphyrin IX in calibrated phantoms

(2018) Laure Alston et al.   JOURNAL OF BIOMEDICAL OPTICS

Visualization technologies for 5-ALA-based fluorescence-guided surgeries

(2018) Linpeng Wei et al.   JOURNAL OF NEURO-ONCOLOGY

Polarized Light Field Imaging for Single-Shot Reflectance Separation

(2018) Jaewon Kim et al.   SENSORS

Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery—review of the literature

(2017) Eric Suero Molina et al.   NEUROSURGICAL REVIEW

qF-SSOP: real-time optical property corrected fluorescence imaging

(2017) Pablo A. Valdes et al.   Biomedical Optics Express

Optical properties, spectral, and lifetime measurements of central nervous system tumors in humans

(2017) F. Poulon et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Optical technologies for intraoperative neurosurgical guidance

(2016) Pablo A. Valdés et al.   Neurosurgical Focus

Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX

(2016) Kara M. Harmatys et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery

(2015) Pablo A. Valdés et al.   JOURNAL OF NEUROSURGERY

What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?

(2015) Costas G. Hadjipanayis et al.   NEUROSURGERY

5-Aminolevulinic Acid-derived Tumor Fluorescence

(2013) Walter Stummer et al.   NEUROSURGERY

System and methods for wide-field quantitative fluorescence imaging during neurosurgery

(2013) Pablo A. Valdes et al.   OPTICS LETTERS

Two-peaked 5-ALA-induced PpIX fluorescence emission spectrum distinguishes glioblastomas from low grade gliomas and infiltrative component of glioblastomas

(2013) Bruno Montcel et al.   Biomedical Optics Express

Involvement of tumor acidification in brain cancer pathophysiology

(2013) Avinash Honasoge et al.   Frontiers in Physiology

Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models

(2012) Soren D. Konecky et al.   JOURNAL OF BIOMEDICAL OPTICS

Gross Total Resection Rates in Contemporary Glioblastoma Surgery

(2012) Philippe Schucht et al.   NEUROSURGERY

A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery

(2012) P. A. Valdés et al.   OPTICS LETTERS

Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro

(2012) Yuichiro Hagiya et al.   Photodiagnosis and Photodynamic Therapy

Quantitative, spectrally-resolved intraoperative fluorescence imaging

(2012) Pablo A. Valdés et al.   Scientific Reports

Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery

(2011) Pablo A. Valdés et al.   JOURNAL OF BIOMEDICAL OPTICS

Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker

(2011) Pablo A. Valdés et al.   JOURNAL OF NEUROSURGERY

 -aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy

(2011) P. A. Valdes et al.   NEURO-ONCOLOGY

Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification

(2010) Takehiro Ando et al.   Brain Tumor Pathology

Review of Neurosurgical Fluorescence Imaging Methodologies

(2010) Brian W Pogue et al.   IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements

(2010) Anthony Kim et al.   JOURNAL OF BIOMEDICAL OPTICS

Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid–induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters

(2010) David W. Roberts et al.   JOURNAL OF NEUROSURGERY

5-Aminolevulinic Acid-induced Protoporphyrin IX Levels in Tissue of Human Malignant Brain Tumors

(2010) Ann Johansson et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Three-dimensional surface profile intensity correction for spatially modulated imaging

(2009) Sylvain Gioux et al.   JOURNAL OF BIOMEDICAL OPTICS

Deferoxamine Iron Chelation Increases δ-Aminolevulinic Acid Induced Protoporphyrin IX in Xenograft Glioma Model

(2009) Pablo A. Valdés et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY