Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Immunology
Konstantin Doberer, Johannes Klaeger, Guido A. Gualdoni, Katharina A. Mayer, Farsad Eskandary, Evan A. Farkash, Hermine Agis, Thomas Reiter, Roman Reindl-Schwaighofer, Markus Wahrmann, Gerald Cohen, Helmuth Haslacher, Gregor Bond, Ingrid Simonitsch-Klupp, Philip F. Halloran, Georg A. Boehmig
Summary: The study highlights the potential of targeting CD38 for plasma cell and NK cell depletion in treating AMR. The use of daratumumab in a kidney allograft recipient with chronic active AMR led to significant improvements in immune cell counts, donor-specific antibody levels, and rejection-related gene expression patterns. This innovative treatment concept shows promise for future trials in organ transplantation research.
Article
Medicine, Research & Experimental
Xin Li, Ruoying Li, Bingqing Ji, Lili Zhao, Junpeng Wang, Tianzhong Yan
Summary: This study investigated the metagenomic and metabolic patterns of gut microbiota in patients with antibody-mediated rejection (AMR) after kidney transplantation. The findings provide a comprehensive understanding of the correlation between AMR and gut microbiota, which is important for the etiological and diagnostic study of AMR after kidney transplantation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Chang Liu, Pengpeng Yan, Xiaoyu Xu, Wenhui Zhou, Dhayakumar Rajan Prakash, Shuqi Wang, Junnian Zhou, Rending Wang, Hongfeng Huang, Jianghua Chen, Hongbo Zhang, Jia Shen
Summary: By utilizing a site-specific nanovehicle, this study presents a novel approach for treating ABMR. The nanovehicle is capable of targeting the affected allograft kidney endothelium under ABMR and releasing an anti-inflammatory drug upon laser irradiation to promote endothelial recovery. This strategy holds potential for future clinical applications.
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Brian T. Lee, M. Isabel Fiel, Thomas D. Schiano
Summary: Antibody-mediated rejection after liver transplantation is a lesser recognized cause of allograft injury, with challenges in timely diagnosis and treatment, highlighting the need for further research and development in this area.
JOURNAL OF HEPATOLOGY
(2021)
Article
Urology & Nephrology
Elodie Bailly, Camila Macedo, Jason Ossart, Kevin Louis, Xinyan Gu, Bala Ramaswami, Carol Bentlejewski, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
Summary: CD160+ IL-21R+ NK cells play a crucial role in kidney allograft antibody-mediated rejection. These cells exhibit distinct phenotypic and functional characteristics and are involved in the rejection response by activating multiple signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Review
Immunology
Yoshiko Matsuda, Takeshi Watanabe, Xiao-Kang Li
Summary: Controlling antibody-mediated allograft rejection requires prediction of onset, therapeutic intervention, and detailed immune monitoring methods. Research focuses on understanding the role of immune cells in LLPC differentiation, exploring novel control methods to enhance clinical applications and improve patient prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Nissrin Alachkar, Nada Alachkar
Summary: Diagnosing kidney allograft rejection is complex and subjective, but an automated Banff classification could make assessment easier and improve accuracy.
Article
Immunology
Claire Tinel, Baptiste Lamarthee, Jasper Callemeyn, Elisabet Van Loon, Virginia Sauvaget, Lise Morin, Laila Aouni, Marion Rabant, Wilfried Gwinner, Pierre Marquet, Maarten Naesens, Dany Anglicheau
Summary: miRNAs play key roles in antibody-mediated rejection in solid-organ transplantation by regulating cellular functions, such as endothelial cells, epithelial cells, and immune cells, impacting the development of microvascular inflammation as well as renal immune response and electrolyte homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jinwen Lin, Junhao Lv, Xianping Yu, Xing Xue, Shiping Yu, Huiping Wang, Jianghua Chen
Summary: A genetic engineered membrane-coated nanoparticle called DSA trapper, inspired by the affinity of bacterial proteins for antibodies, is able to efficiently adsorb and clear alloreactive antibodies, restoring single-cell transcriptional heterogeneity. DSA trappers absorbed antibodies through heterophagic clearance, reducing IgG deposition and complement activation, providing an immune tolerant niche for restoration of single-cell genetic architecture. In allogeneic transplantation mice, DSA trapper improved glomerular filtration rate and prolonged survival. Overall, DSA trapper offers a promising approach for treating alloantibody-mediated immune injury.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Medicine, General & Internal
Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad
Summary: Despite advances in immunosuppressive medications, antibody-mediated rejection (AMR) remains a major cause of kidney allograft failure. Recent developments in understanding the pathophysiology of AMR and new therapeutic options have emerged. Surveillance protocols using donor-derived cell-free DNA and gene profile testing have allowed for early detection of AMR. Ongoing clinical trials offer opportunities for improving outcomes in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kaiyin Wu, Danilo Schmidt, Covadonga Lopez del Moral, Bilgin Osmanodja, Nils Lachmann, Qiang Zhang, Fabian Halleck, Mira Choi, Friederike Bachmann, Simon Ronicke, Wiebke Duettmann, Marcel G. Naik, Eva Schrezenmeier, Birgit Rudolph, Klemens Budde
Summary: The study retrospectively investigated renal allograft function and long-term outcomes in patients with chronic antibody-mediated rejection (cAMR), and found that patients who received antihumoral therapy had more concomitant T-cell-mediated rejection and a higher decline in renal function, with lower graft survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Fei Han, Qipeng Sun, Zhengyu Huang, Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study reveals that donor plasma mitochondrial DNA (dmtDNA) levels are correlated with the occurrence of antibody-mediated rejection (ABMR) in renal allograft recipients. Higher dmtDNA levels are associated with acute rejection and ABMR, presenting dmtDNA as a potential predictive marker for ABMR in organ evaluation.