Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

(2021) Nikhil C. Munshi et al.   NEW ENGLAND JOURNAL OF MEDICINE

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

(2021) Axel Hyrenius-Wittsten et al.   Science Translational Medicine

Advances in Universal CAR-T Cell Therapy

(2021) Haolong Lin et al.   Frontiers in Immunology

O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

(2020) Wei Yu et al.   Frontiers in Oncology

Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor

(2020) Nicholas G. Minutolo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptor CAR Platforms—Next Generation of T Cell-Based Cancer Immunotherapy

(2020) Claudia Arndt et al.   Cancers

Using the SNAP-Tag technology to easily measure and demonstrate apoptotic changes in cancer and blood cells with different dyes

(2020) Mira Woitok et al.   PLoS One

The Emergence of Universal Immune Receptor T Cell Therapy for Cancer

(2019) Nicholas G. Minutolo et al.   Frontiers in Oncology

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors

(2018) Yong Gu Lee et al.   CANCER RESEARCH

Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation

(2017) Ryosuke Kojima et al.   Nature Chemical Biology

Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines

(2017) Jason Lohmueller et al.   PHARMACOLOGY & THERAPEUTICS

Real-time Characterization of Antibody Binding to Receptors on Living Immune Cells

(2017) Sina Bondza et al.   Frontiers in Immunology

mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting

(2017) Jason J. Lohmueller et al.   OncoImmunology

A novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform

(2017) Susann Albert et al.   OncoImmunology

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

Rewiring human cellular input–output using modular extracellular sensors

(2016) Kelly A Schwarz et al.   Nature Chemical Biology

Versatile strategy for controlling the specificity and activity of engineered T cells

(2016) Jennifer S. Y. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

(2016) David T. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmable polyproteams built using twin peptide superglues

(2016) Gianluca Veggiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential

(2016) Jason J. Lohmueller et al.   Scientific Reports

Redirection of Genetically Engineered CAR-T Cells Using Bifunctional Small Molecules

(2015) Min Soo Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Genetic targeting of chemical indicators in vivo

(2014) Guoying Yang et al.   NATURE METHODS

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Short Peptide Tag for Covalent Protein Labeling Based on Coiled Coils

(2013) Jianpeng Wang et al.   BIOCONJUGATE CHEMISTRY

T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing

(2013) K. Kudo et al.   CANCER RESEARCH

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

(2013) M. V. Maus et al.   Cancer Immunology Research

Stable, high-affinity streptavidin monomer for protein labeling and monovalent biotin detection

(2012) Kok Hong Lim et al.   BIOTECHNOLOGY AND BIOENGINEERING

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

(2012) B. G. Till et al.   BLOOD

A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor

(2012) K. Urbanska et al.   CANCER RESEARCH

Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies

(2012) K. Tamada et al.   CLINICAL CANCER RESEARCH

Development of SNAP-Tag Fluorogenic Probes for Wash-Free Fluorescence Imaging

(2011) Xiaoli Sun et al.   CHEMBIOCHEM

Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag

(2011) Cláudia Campos et al.   DEVELOPMENTAL DYNAMICS

Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation

(2009) A. Talavera et al.   CANCER RESEARCH

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

(2009) James N. Kochenderfer et al.   JOURNAL OF IMMUNOTHERAPY

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

(2008) Arnaud Gautier et al.   CHEMISTRY & BIOLOGY