Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport

The glymphatic hypothesis: the theory and the evidence

(2022) Stephen B. Hladky et al.   Fluids and Barriers of the CNS

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

(2022) Celia Kjaerby et al.   NATURE NEUROSCIENCE

Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

(2022) Humberto Mestre et al.   Nature Communications

The glymphatic system: Current understanding and modeling

(2022) Tomas Bohr et al.   iScience

Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

(2021) Steven T. Proulx   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of tracer transport in cerebral perivascular spaces

(2021) Mohammad M. Faghih et al.   JOURNAL OF BIOMECHANICS

Fluid Transport in the Brain

(2021) Martin Kaag Rasmussen et al.   PHYSIOLOGICAL REVIEWS

Begonia—A Two-Photon Imaging Analysis Pipeline for Astrocytic Ca2+ Signals

(2021) Daniel M. Bjørnstad et al.   Frontiers in Cellular Neuroscience

Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback

(2021) Jordan N. Haidey et al.   Cell Reports

The interconnected causes and consequences of sleep in the brain

(2021) Laura D. Lewis   SCIENCE

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

(2020) Laura Bojarskaite et al.   Nature Communications

Functional hyperemia drives fluid exchange in the paravascular space

(2020) Ravi Teja Kedarasetti et al.   Fluids and Barriers of the CNS

The mechanisms behind perivascular fluid flow

(2020) Cécile Daversin-Catty et al.   PLoS One

Respiratory influence on cerebrospinal fluid flow – a computational study based on long-term intracranial pressure measurements

(2019) Vegard Vinje et al.   Scientific Reports

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

(2019) Susanne J. van Veluw et al.   NEURON

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep

(2018) Antoine Bergel et al.   Nature Communications

Molecular characterization of perivascular drainage pathways in the murine brain

(2017) Melanie-Jane Hannocks et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents

(2017) Julie Seibt et al.   Nature Communications

Sleep-Stage-Specific Regulation of Cortical Excitation and Inhibition

(2016) Niels Niethard et al.   CURRENT BIOLOGY

Diffusion of macromolecules in a polymer hydrogel: from microscopic to macroscopic scales

(2016) D. Sandrin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Natural Whisker-Guided Behavior by Head-Fixed Mice in Tactile Virtual Reality

(2014) N. J. Sofroniew et al.   JOURNAL OF NEUROSCIENCE

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Nocturnal awakenings and comorbid disorders in the American general population

(2008) Maurice M. Ohayon   JOURNAL OF PSYCHIATRIC RESEARCH

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS