Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection

(2022) Ning Yang et al.   Nature Communications

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

(2021) Juan García-Arriaza et al.   JOURNAL OF VIROLOGY

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

(2021) Nanda Kishore Routhu et al.   IMMUNITY

One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection

(2021) Ruikang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation and chromatin tethering prevent cGAS activation during mitosis

(2021) Tuo Li et al.   SCIENCE

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination

(2021) Alina Tscherne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling

(2020) Bokai Song et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of Post-Translational Modifications of cGAS in Innate Immunity

(2020) Yakun Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

Vaccinia Virus Activation and Antagonism of Cytosolic DNA Sensing

(2020) Misbah El-Jesr et al.   Frontiers in Immunology

Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive

(2019) Anna Fedotova et al.   Epigenetics & Chromatin

The Vaccinia virion: Filling the gap between atomic and ultrastructure

(2019) Yeva Mirzakhanyan et al.   PLoS Pathogens

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

(2019) James B. Eaglesham et al.   NATURE

Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

(2019) Phillip R. Pittman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

(2019) Eric B. Wong et al.   PLoS Pathogens

Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation

(2018) Iliana Georgana et al.   JOURNAL OF VIROLOGY

Identification of Poxvirus Genome Uncoating and DNA Replication Factors with Mutually Redundant Roles

(2018) Baoming Liu et al.   JOURNAL OF VIROLOGY

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit

(2018) Nathan Meade et al.   CELL

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

(2018) Simon R. Scutts et al.   Cell Reports

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

(2017) Qiang Wang et al.   PLoS Pathogens

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

(2015) Zhe Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

(2014) Peihong Dai et al.   PLoS Pathogens

The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors

(2013) Q. Dai et al.   GENES & DEVELOPMENT

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

(2013) B. J. Ferguson et al.   JOURNAL OF GENERAL VIROLOGY

Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection

(2013) C. T. O. Benfield et al.   JOURNAL OF GENERAL VIROLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

(2013) Nicholas E. Peters et al.   PLoS Pathogens

The C11R Gene, Which Encodes the Vaccinia Virus Growth Factor, Is Partially Responsible for MVA-Induced NF-κB and ERK2 Activation

(2012) Stefani Martin et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

A BEN-domain-containing protein associates with heterochromatin and represses transcription

(2011) K. M. Sathyan et al.   JOURNAL OF CELL SCIENCE

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

(2011) Leonie Unterholzner et al.   PLoS Pathogens

Smallpox vaccines: targets of protective immunity

(2010) Bernard Moss   IMMUNOLOGICAL REVIEWS

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing

(2010) Z. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

The Orthopoxvirus 68-Kilodalton Ankyrin-Like Protein Is Essential for DNA Replication and Complete Gene Expression of Modified Vaccinia Virus Ankara in Nonpermissive Human and Murine Cells

(2009) K. M. Sperling et al.   JOURNAL OF VIROLOGY

BEN: a novel domain in chromatin factors and DNA viral proteins

(2008) Saraswathi Abhiman et al.   BIOINFORMATICS

Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3

(2008) L. Deng et al.   JOURNAL OF VIROLOGY

Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14

(2008) Ron A.-J. Chen et al.   PLoS Pathogens

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE